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- W4308259588 abstract "The term ferroptosis was put forward in 2012 and has been researched exponentially over the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed cell death, which belongs to a type of necrosis and is distinguished from apoptosis and autophagy. Actuated by iron-dependent phospholipid peroxidation, ferroptosis is modulated by various cellular metabolic and signaling pathways, including amino acid, lipid, iron, and mitochondrial metabolism. Notably, ferroptosis is associated with numerous diseases and plays a double-edged sword role. Particularly, metastasis-prone or highly-mutated tumor cells are sensitive to ferroptosis. Hence, inducing or prohibiting ferroptosis in tumor cells has vastly promising potential in treating drug-resistant cancers. Immunotolerant cancer cells are not sensitive to the traditional cell death pathway such as apoptosis and necroptosis, while ferroptosis plays a crucial role in mediating tumor and immune cells to antagonize immune tolerance, which has broad prospects in the clinical setting. Herein, we summarized the mechanisms and delineated the regulatory network of ferroptosis, emphasized its dual role in mediating immune tolerance, proposed its significant clinical benefits in the tumor immune microenvironment, and ultimately presented some provocative doubts. This review aims to provide practical guidelines and research directions for the clinical practice of ferroptosis in treating immune-resistant tumors." @default.
- W4308259588 created "2022-11-09" @default.
- W4308259588 creator A5003642180 @default.
- W4308259588 creator A5029410439 @default.
- W4308259588 creator A5042789457 @default.
- W4308259588 creator A5054644660 @default.
- W4308259588 creator A5064094142 @default.
- W4308259588 creator A5074864641 @default.
- W4308259588 date "2022-11-05" @default.
- W4308259588 modified "2023-10-17" @default.
- W4308259588 title "Ferroptosis: a double-edged sword mediating immune tolerance of cancer" @default.
- W4308259588 cites W1490370778 @default.
- W4308259588 cites W1549643599 @default.
- W4308259588 cites W1626920792 @default.
- W4308259588 cites W1798710600 @default.
- W4308259588 cites W1836073275 @default.
- W4308259588 cites W1849097877 @default.
- W4308259588 cites W1963423101 @default.
- W4308259588 cites W1964799185 @default.
- W4308259588 cites W1966176339 @default.
- W4308259588 cites W1966421936 @default.
- W4308259588 cites W1970926002 @default.
- W4308259588 cites W1976955003 @default.
- W4308259588 cites W1980780108 @default.
- W4308259588 cites W1982488143 @default.
- W4308259588 cites W1984492299 @default.
- W4308259588 cites W1990171977 @default.
- W4308259588 cites W1990227965 @default.
- W4308259588 cites W1991471550 @default.
- W4308259588 cites W1996072289 @default.
- W4308259588 cites W1997183854 @default.
- W4308259588 cites W1998642504 @default.
- W4308259588 cites W1998664010 @default.
- W4308259588 cites W1999075493 @default.
- W4308259588 cites W2002490399 @default.
- W4308259588 cites W2006358233 @default.
- W4308259588 cites W2006778392 @default.
- W4308259588 cites W2011538447 @default.
- W4308259588 cites W2016063936 @default.
- W4308259588 cites W2017390384 @default.
- W4308259588 cites W2020914260 @default.
- W4308259588 cites W2025128734 @default.
- W4308259588 cites W2025757893 @default.
- W4308259588 cites W2029086221 @default.
- W4308259588 cites W2031418918 @default.
- W4308259588 cites W2035898183 @default.
- W4308259588 cites W2036489403 @default.
- W4308259588 cites W2037683223 @default.
- W4308259588 cites W2047662292 @default.
- W4308259588 cites W2049078823 @default.
- W4308259588 cites W2050432242 @default.
- W4308259588 cites W2050746675 @default.
- W4308259588 cites W2053387982 @default.
- W4308259588 cites W2057632732 @default.
- W4308259588 cites W2057893793 @default.
- W4308259588 cites W2060035882 @default.
- W4308259588 cites W2067107606 @default.
- W4308259588 cites W2067182963 @default.
- W4308259588 cites W2068225706 @default.
- W4308259588 cites W2068701781 @default.
- W4308259588 cites W2070915732 @default.
- W4308259588 cites W2073382063 @default.
- W4308259588 cites W2076308913 @default.
- W4308259588 cites W2077243848 @default.
- W4308259588 cites W2079212747 @default.
- W4308259588 cites W2080641261 @default.
- W4308259588 cites W2082511119 @default.
- W4308259588 cites W2084092576 @default.
- W4308259588 cites W2085213267 @default.
- W4308259588 cites W2088883749 @default.
- W4308259588 cites W2099751212 @default.
- W4308259588 cites W2100211004 @default.
- W4308259588 cites W2101492664 @default.
- W4308259588 cites W2106213970 @default.
- W4308259588 cites W2117820574 @default.
- W4308259588 cites W2122341467 @default.
- W4308259588 cites W2123774062 @default.
- W4308259588 cites W2128035403 @default.
- W4308259588 cites W2129723413 @default.
- W4308259588 cites W2136313650 @default.
- W4308259588 cites W2142943268 @default.
- W4308259588 cites W2143163879 @default.
- W4308259588 cites W2144818107 @default.
- W4308259588 cites W2146810078 @default.
- W4308259588 cites W2149640531 @default.
- W4308259588 cites W2158348986 @default.
- W4308259588 cites W2160834915 @default.
- W4308259588 cites W2163005196 @default.
- W4308259588 cites W2163294546 @default.
- W4308259588 cites W2165625761 @default.
- W4308259588 cites W2166053801 @default.
- W4308259588 cites W2171026458 @default.
- W4308259588 cites W2171480930 @default.
- W4308259588 cites W2258482782 @default.
- W4308259588 cites W2258749495 @default.
- W4308259588 cites W2291832556 @default.
- W4308259588 cites W2320177900 @default.
- W4308259588 cites W2345350059 @default.
- W4308259588 cites W2402102936 @default.
- W4308259588 cites W2414659015 @default.