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- W4308261378 abstract "Abstract The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized transporter systems which regulate transcellular transport. However, existing in vitro models of the BBB display variable accuracy across a wide range of characteristics including gene/protein expression and barrier function. Here, we use an isogenic family of fluorescently-labeled iPSC-derived BMEC-like cells (iBMECs) and brain pericyte-like cells (iPCs) within two-dimensional confluent monolayers (2D) and three-dimensional (3D) tissue-engineered microvessels to explore how 3D microenvironment regulates gene expression and function of the in vitro BBB. We show that 3D microenvironment (shear stress, cell-ECM interactions, and cylindrical geometry) increases BBB phenotype and endothelial identity, and alters angiogenic and cytokine responses in synergy with pericyte co-culture. Tissue-engineered microvessels incorporating junction-labeled iBMECs enable study of the real-time dynamics of tight junctions during homeostasis and in response to physical and chemical perturbations." @default.
- W4308261378 created "2022-11-09" @default.
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- W4308261378 date "2022-11-05" @default.
- W4308261378 modified "2023-10-09" @default.
- W4308261378 title "Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels" @default.
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- W4308261378 cites W1975523864 @default.
- W4308261378 cites W1998802487 @default.
- W4308261378 cites W2000009097 @default.
- W4308261378 cites W2001726213 @default.
- W4308261378 cites W2017119076 @default.
- W4308261378 cites W2030588597 @default.
- W4308261378 cites W2042883482 @default.
- W4308261378 cites W2042938829 @default.
- W4308261378 cites W2046827775 @default.
- W4308261378 cites W2064183478 @default.
- W4308261378 cites W2071547067 @default.
- W4308261378 cites W2073077090 @default.
- W4308261378 cites W2076634690 @default.
- W4308261378 cites W2079218282 @default.
- W4308261378 cites W2080938528 @default.
- W4308261378 cites W2081148102 @default.
- W4308261378 cites W2102813529 @default.
- W4308261378 cites W2116901311 @default.
- W4308261378 cites W2130410032 @default.
- W4308261378 cites W2147425799 @default.
- W4308261378 cites W2155436051 @default.
- W4308261378 cites W2179438025 @default.
- W4308261378 cites W2191292005 @default.
- W4308261378 cites W2198267160 @default.
- W4308261378 cites W2214074259 @default.
- W4308261378 cites W2216176623 @default.
- W4308261378 cites W2259938310 @default.
- W4308261378 cites W2289500363 @default.
- W4308261378 cites W2331427622 @default.
- W4308261378 cites W2341259444 @default.
- W4308261378 cites W2395353947 @default.
- W4308261378 cites W2605784193 @default.
- W4308261378 cites W2611456245 @default.
- W4308261378 cites W2740294724 @default.
- W4308261378 cites W2757164738 @default.
- W4308261378 cites W2767330810 @default.
- W4308261378 cites W2768631628 @default.
- W4308261378 cites W2770491814 @default.
- W4308261378 cites W2786608785 @default.
- W4308261378 cites W2800781066 @default.
- W4308261378 cites W2883212753 @default.
- W4308261378 cites W2887710298 @default.
- W4308261378 cites W2898464988 @default.
- W4308261378 cites W2902853584 @default.
- W4308261378 cites W2948607383 @default.
- W4308261378 cites W2950464315 @default.
- W4308261378 cites W2950570577 @default.
- W4308261378 cites W2953365051 @default.
- W4308261378 cites W2953383090 @default.
- W4308261378 cites W2989057373 @default.
- W4308261378 cites W2999402088 @default.
- W4308261378 cites W3009465414 @default.
- W4308261378 cites W3017429739 @default.
- W4308261378 cites W3042870380 @default.
- W4308261378 cites W3044248457 @default.
- W4308261378 cites W3044892863 @default.
- W4308261378 cites W3045585426 @default.
- W4308261378 cites W3047250357 @default.
- W4308261378 cites W3093034170 @default.
- W4308261378 cites W3095807815 @default.
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- W4308261378 cites W3132846957 @default.
- W4308261378 cites W3134181834 @default.
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- W4308261378 cites W3167836493 @default.
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- W4308261378 doi "https://doi.org/10.1186/s12987-022-00377-1" @default.
- W4308261378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36333694" @default.
- W4308261378 hasPublicationYear "2022" @default.
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