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- W4308261763 abstract "Abstract Transition to transversion ratio ( ti/tv ) is important in understanding the mutational bias in the evolution of an organism. Since synonymous polymorphism for two-fold degenerate codons depends only on transitions, the ti/tv ratios of two-fold degenerate codons and four-fold degenerate codons are expected to be different for synonymous as well as non-synonymous mutations. Therefore, in any organism, the ti/tv ratio is likely to vary among coding sequences having differences in degenerate codon composition. In addition to the above, compositional variation of pretermination codon among the coding sequences is also likely to influence the ti/tv ratio because purifying selection is stronger on non-synonymous substitutions leading to termination codons. In this study we have improved the method of finding the ratio between transition to transversion, synonymous transition to synonymous transversion and non-synonymous transition to non-synonymous transversion and developed a computational algorithm to calculate the ti/tv values. Our analyses in 2516 coding sequences in the E. coli genome suggested a strong correlation of codon degeneracy with synonymous transition to transversion ratio. Additionally, we have observed a moderate correlation of pretermination codons with non-synonymous transition to transversion ratio. We believe that the improved method developed in this study can be potentially employed in finding the ti/tv ratio in coding sequences of other genomes." @default.
- W4308261763 created "2022-11-09" @default.
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- W4308261763 date "2022-11-04" @default.
- W4308261763 modified "2023-09-24" @default.
- W4308261763 title "Codon degeneracy as well as pretermination codons influence transition to transversion ratio in coding sequences" @default.
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- W4308261763 doi "https://doi.org/10.1101/2022.11.03.515082" @default.
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