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- W4308263525 abstract "Abstract The effect of anti-vascular endothelial growth factor on neonatal lung development was inconclusive. To evaluate pulmonary function in school-age children who have received intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP), this study included 118 school-aged children who were grouped into three groups: full-term control children (group 1), preterm children who had not received IVB treatment (group 2) and preterm children with ROP who had received IVB treatment (group 3). Pulmonary function was measured by spirometry and impulse oscillometry. Pulmonary function was significantly better in group 1 than in groups 2 and 3 (all p < 0.05 in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), forced expiratory flow between 25 and 75% of FVC (FEF 25–75 ), and respiratory resistance at 5 Hz and difference between respiratory resistance at 5 and 20 Hz (R5-R20). There were no statistically significant differences between group 2 and group 3 in all pulmonary function parameters, including FVC, FEV 1 , ratio of FEV 1 to FVC, FEF 25-75 , R5, R20, R5–R20, and respiratory reactance at 5 Hz. In conclusion, our study revealed that preterm infants receiving IVB for ROP had comparable pulmonary function at school age to their preterm peers who had not received IVB treatment." @default.
- W4308263525 created "2022-11-09" @default.
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- W4308263525 date "2022-11-05" @default.
- W4308263525 modified "2023-10-13" @default.
- W4308263525 title "Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity" @default.
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- W4308263525 doi "https://doi.org/10.1038/s41598-022-22338-2" @default.
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