FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308266712> ?p ?o ?g. }

• W4308266712 endingPage "113960" @default.
• W4308266712 startingPage "113960" @default.
• W4308266712 abstract "In the current investigation, 5-epi-incensole (3) and 5-epi-incensole acetate (5) were synthesized from the most potent anti-depressant constituents incensole (1) and incensole acetate (2) of Boswellia papyrifera Hochst. The resulting compounds were evaluated for their ability to ameliorate depressive symptoms in forced swim test (FST) and tail suspension test (TST) in chronic unpredictable mild stress (CUMS) induced depression paradigm. The results demonstrated that compounds 3 and 5 at the doses of 1 and 3 mg/kg administered for 28 days, significantly reduced the immobility time in FST and TST and were devoid of any effect on locomotor activity in the open field test (OFT). Both compounds 3 and 5 also reversed CUMS-induced reduction in the weight of animals and aversion in sucrose preference. The tested compounds also inhibited Monoamine oxidase-A (MAO) enzyme and increased the levels of brain noradrenaline (NA) and 5-Hydroxytryptamine (5-HT), decreased plasma corticosterone and pro-inflammatory cytokines including TNF-α, IL-6 in hippocampal homogenates. Compounds 3 and 5 also significantly reduced the increased lipid peroxidation and nitrite levels; decreased glutathione levels, and catalase activities in mice undergoing CUMS protocol. The binding mode of compounds 3 and 5 was predicted at the monoamine oxidase substrate binding site by molecular docking having docking scores of > -6 kcal/mol. Taken together these data revealed that compounds 3 and 5 exerted antidepressant-like effects in chronic unpredictable mild stress-induced depression paradigm and are likely mediated via modulating the central oxidative stress, MAO-A activity with a consequent increase in brain NA and 5-HT levels in inflammatory pathways." @default.
• W4308266712 created "2022-11-09" @default.
• W4308266712 creator A5005097620 @default.
• W4308266712 creator A5009409522 @default.
• W4308266712 creator A5032226045 @default.
• W4308266712 creator A5032828510 @default.
• W4308266712 creator A5062147223 @default.
• W4308266712 creator A5070549119 @default.
• W4308266712 creator A5074076151 @default.
• W4308266712 creator A5076140757 @default.
• W4308266712 creator A5091778180 @default.
• W4308266712 date "2022-12-01" @default.
• W4308266712 modified "2023-10-11" @default.
• W4308266712 title "Synthesis and antidepressant-like effects of new 5-epi-incensole and 5-epi- incensole acetate in chronic unpredictable mild stress model of depression; behavioural and biochemical correlates" @default.
• W4308266712 cites W1532532680 @default.
• W4308266712 cites W1831597539 @default.
• W4308266712 cites W1966847958 @default.
• W4308266712 cites W1973386992 @default.
• W4308266712 cites W1974390576 @default.
• W4308266712 cites W1986875797 @default.
• W4308266712 cites W1988157043 @default.
• W4308266712 cites W1990802251 @default.
• W4308266712 cites W2004079184 @default.
• W4308266712 cites W2005594217 @default.
• W4308266712 cites W2015984453 @default.
• W4308266712 cites W2032107185 @default.
• W4308266712 cites W2035579644 @default.
• W4308266712 cites W2041036432 @default.
• W4308266712 cites W2048513018 @default.
• W4308266712 cites W2053472601 @default.
• W4308266712 cites W2054253103 @default.
• W4308266712 cites W2063579231 @default.
• W4308266712 cites W2065313926 @default.
• W4308266712 cites W2066457796 @default.
• W4308266712 cites W2068879317 @default.
• W4308266712 cites W2073092594 @default.
• W4308266712 cites W2074847975 @default.
• W4308266712 cites W2076427124 @default.
• W4308266712 cites W2077952072 @default.
• W4308266712 cites W2083048709 @default.
• W4308266712 cites W2087778925 @default.
• W4308266712 cites W2117257450 @default.
• W4308266712 cites W2125521135 @default.
• W4308266712 cites W2131220396 @default.
• W4308266712 cites W2149563935 @default.
• W4308266712 cites W2471201362 @default.
• W4308266712 cites W2505284622 @default.
• W4308266712 cites W2546247999 @default.
• W4308266712 cites W2564813949 @default.
• W4308266712 cites W2593280156 @default.
• W4308266712 cites W2730900010 @default.
• W4308266712 cites W2803589537 @default.
• W4308266712 cites W2889388588 @default.
• W4308266712 cites W2891172532 @default.
• W4308266712 cites W2912456649 @default.
• W4308266712 cites W2939918092 @default.
• W4308266712 cites W2990306165 @default.
• W4308266712 cites W3138774164 @default.
• W4308266712 cites W4249359910 @default.
• W4308266712 cites W4293247451 @default.
• W4308266712 cites W946264949 @default.
• W4308266712 doi "https://doi.org/10.1016/j.biopha.2022.113960" @default.
• W4308266712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36411640" @default.
• W4308266712 hasPublicationYear "2022" @default.
• W4308266712 type Work @default.
• W4308266712 citedByCount "1" @default.
• W4308266712 countsByYear W43082667122023 @default.
• W4308266712 crossrefType "journal-article" @default.
• W4308266712 hasAuthorship W4308266712A5005097620 @default.
• W4308266712 hasAuthorship W4308266712A5009409522 @default.
• W4308266712 hasAuthorship W4308266712A5032226045 @default.
• W4308266712 hasAuthorship W4308266712A5032828510 @default.
• W4308266712 hasAuthorship W4308266712A5062147223 @default.
• W4308266712 hasAuthorship W4308266712A5070549119 @default.
• W4308266712 hasAuthorship W4308266712A5074076151 @default.
• W4308266712 hasAuthorship W4308266712A5076140757 @default.
• W4308266712 hasAuthorship W4308266712A5091778180 @default.
• W4308266712 hasBestOaLocation W43082667121 @default.
• W4308266712 hasConcept C126322002 @default.
• W4308266712 hasConcept C134018914 @default.
• W4308266712 hasConcept C136569192 @default.
• W4308266712 hasConcept C170493617 @default.
• W4308266712 hasConcept C181199279 @default.
• W4308266712 hasConcept C185592680 @default.
• W4308266712 hasConcept C187714386 @default.
• W4308266712 hasConcept C2775864247 @default.
• W4308266712 hasConcept C2776024655 @default.
• W4308266712 hasConcept C2776134451 @default.
• W4308266712 hasConcept C2776151105 @default.
• W4308266712 hasConcept C2778875871 @default.
• W4308266712 hasConcept C2779085643 @default.
• W4308266712 hasConcept C2779177272 @default.
• W4308266712 hasConcept C2781001258 @default.
• W4308266712 hasConcept C2781073023 @default.
• W4308266712 hasConcept C2781161787 @default.
• W4308266712 hasConcept C55493867 @default.
• W4308266712 hasConcept C71924100 @default.
• W4308266712 hasConcept C98274493 @default.

• next