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- W4308271431 abstract "Abstract Ebolaviruses Ebola (EBOV), Sudan (SUDV) and Bundibugyo (BDBV) cause severe human disease, which may be accompanied by hemorrhagic syndrome, with high case fatality rates. Monovalent vaccines do not offer cross-protection against these viruses whose endemic areas overlap. Therefore, development of a panebolavirus vaccine is a priority. As a vaccine vector, human parainfluenza virus type 3 (HPIV3) has the advantages of needle-free administration and induction of both systemic and local mucosal antibody responses in the respiratory tract. We developed a HPIV3-vectored combination vaccine against EBOV, SUDV and BDBV. To minimize the anti-vector immunity, HPIV3 envelope genes were removed from the vaccine constructs which express only the ebolavirus envelope protein – glycoprotein (GP). A single intranasal vaccination of guinea pigs or ferrets with the trivalent combination vaccine elicited humoral responses to each of the targeted ebolaviruses, including binding and neutralizing antibodies, as well as Fc-mediated effector functions. This vaccine protected animals from death and disease caused by lethal challenges with EBOV, SUDV or BDBV. Notably, the combination vaccine elicited protection which was comparable to that induced by the monovalent vaccines, thus demonstrating the value of this combination trivalent vaccine." @default.
- W4308271431 created "2022-11-10" @default.
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- W4308271431 date "2022-11-04" @default.
- W4308271431 modified "2023-09-23" @default.
- W4308271431 title "A single dose intranasal combination panebolavirus vaccine" @default.
- W4308271431 doi "https://doi.org/10.21203/rs.3.rs-2211292/v1" @default.
- W4308271431 hasPublicationYear "2022" @default.
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