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- W4308272019 abstract "Giant cell arteritis (GCA) is the most common vasculitis affecting people older than 50 years. The last decades have shed new light on the clinical paradigm of this condition, expanding its spectrum beyond cranial vessel inflammation. GCA can be now considered a multifaceted vasculitic syndrome encompassing inflammation of cranial and extra-cranial arteries and girdles, isolated or combined. Such heterogeneity often leads to diagnostic delays and increases the likelihood of acute and chronic GCA-related damage. On the other hand, the approach to suspected GCA patients has been revolutionized by the introduction of vascular ultrasound which allows a rapid, cost-effective, and non-invasive GCA diagnosis. Likewise, the use of tocilizumab is now part of the therapeutic algorithm of GCA and ensures a satisfactory disease control even in steroid-refractory patients. Nonetheless, some aspects of GCA still need to be clarified, including the clinical correlation of different histological patterns, and the prevention of long-term vascular complications.This narrative review depicts the diagnostic and therapeutic aspects of GCA most relevant in clinical practice, with a focus on clinical updates and novelties introduced over the last decade." @default.
- W4308272019 created "2022-11-10" @default.
- W4308272019 creator A5027512145 @default.
- W4308272019 creator A5033287794 @default.
- W4308272019 creator A5035626409 @default.
- W4308272019 creator A5065403251 @default.
- W4308272019 date "2023-01-01" @default.
- W4308272019 modified "2023-10-02" @default.
- W4308272019 title "Giant cell arteritis: Update on clinical manifestations, diagnosis, and management" @default.
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