FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308280009> ?p ?o ?g. }

• W4308280009 abstract "Abstract Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the differentiation induction. Therefore, the actual capacity of a cell to undergo phenotypic change during a differentiation process relies upon a modification in this balance which favors change-inducing gene expression variability. However, there are no experimental data providing insight on how fast the transcriptomes of identical cells would diverge on the scale of the very first two cell divisions during the differentiation process. In order to quantitatively address this question, we developed different experimental methods to recover the transcriptomes of related cells, after one and two divisions, while preserving the information about their lineage at the scale of a single cell division. We analyzed the transcriptomes of related cells from two differentiation biological systems (human CD34+ cells and T2EC chicken primary erythrocytic progenitors) using two different single-cell transcriptomics technologies (sc-RT-qPCR and scRNA-seq). We identified that the gene transcription profiles of differentiating sister-cells are more similar to each-other than to those of non related cells of the same type, sharing the same environment and undergoing similar biological processes. More importantly, we observed greater discrepancies between differentiating sister-cells than between self-renewing sister-cells. Furthermore, a continuous increase in this divergence from first generation to second generation was observed when comparing differentiating cousin-cells to self renewing cousin-cells. Our results are in favor of a continuous and gradual erasure of transcriptional memory during the differentiation process." @default.
• W4308280009 created "2022-11-10" @default.
• W4308280009 creator A5002495454 @default.
• W4308280009 creator A5010710051 @default.
• W4308280009 creator A5022371994 @default.
• W4308280009 creator A5031867652 @default.
• W4308280009 creator A5034507740 @default.
• W4308280009 creator A5044992849 @default.
• W4308280009 creator A5045366083 @default.
• W4308280009 creator A5048758770 @default.
• W4308280009 creator A5056996972 @default.
• W4308280009 creator A5059563268 @default.
• W4308280009 creator A5076769610 @default.
• W4308280009 creator A5080652620 @default.
• W4308280009 creator A5089245484 @default.
• W4308280009 creator A5091804533 @default.
• W4308280009 date "2022-11-03" @default.
• W4308280009 modified "2023-10-14" @default.
• W4308280009 title "Differentiation is accompanied by a progressive loss in transcriptional memory" @default.
• W4308280009 cites W1509489125 @default.
• W4308280009 cites W1540059158 @default.
• W4308280009 cites W1981995086 @default.
• W4308280009 cites W2001033949 @default.
• W4308280009 cites W2046321916 @default.
• W4308280009 cites W2050826226 @default.
• W4308280009 cites W2060932360 @default.
• W4308280009 cites W2071010503 @default.
• W4308280009 cites W2071877313 @default.
• W4308280009 cites W2073586815 @default.
• W4308280009 cites W2079777306 @default.
• W4308280009 cites W2105512180 @default.
• W4308280009 cites W2107342968 @default.
• W4308280009 cites W2139285351 @default.
• W4308280009 cites W2142806844 @default.
• W4308280009 cites W2150451971 @default.
• W4308280009 cites W2165533158 @default.
• W4308280009 cites W2168221215 @default.
• W4308280009 cites W2302476265 @default.
• W4308280009 cites W2333772027 @default.
• W4308280009 cites W2519132385 @default.
• W4308280009 cites W2570629027 @default.
• W4308280009 cites W2581340604 @default.
• W4308280009 cites W2605897695 @default.
• W4308280009 cites W2616701205 @default.
• W4308280009 cites W2760415787 @default.
• W4308280009 cites W2795460076 @default.
• W4308280009 cites W2808316845 @default.
• W4308280009 cites W2902652978 @default.
• W4308280009 cites W2921683137 @default.
• W4308280009 cites W2921706614 @default.
• W4308280009 cites W2946929667 @default.
• W4308280009 cites W2950647373 @default.
• W4308280009 cites W2951444558 @default.
• W4308280009 cites W2952938648 @default.
• W4308280009 cites W2971871274 @default.
• W4308280009 cites W2972909971 @default.
• W4308280009 cites W2990357870 @default.
• W4308280009 cites W3005287223 @default.
• W4308280009 cites W3005392606 @default.
• W4308280009 cites W3013821085 @default.
• W4308280009 cites W3045872583 @default.
• W4308280009 cites W3157094484 @default.
• W4308280009 cites W3194086652 @default.
• W4308280009 cites W4205689323 @default.
• W4308280009 cites W4220894429 @default.
• W4308280009 cites W4283829667 @default.
• W4308280009 cites W4285091897 @default.
• W4308280009 cites W4297092891 @default.
• W4308280009 cites W4307309172 @default.
• W4308280009 doi "https://doi.org/10.1101/2022.11.02.514828" @default.
• W4308280009 hasPublicationYear "2022" @default.
• W4308280009 type Work @default.
• W4308280009 citedByCount "0" @default.
• W4308280009 crossrefType "posted-content" @default.
• W4308280009 hasAuthorship W4308280009A5002495454 @default.
• W4308280009 hasAuthorship W4308280009A5010710051 @default.
• W4308280009 hasAuthorship W4308280009A5022371994 @default.
• W4308280009 hasAuthorship W4308280009A5031867652 @default.
• W4308280009 hasAuthorship W4308280009A5034507740 @default.
• W4308280009 hasAuthorship W4308280009A5044992849 @default.
• W4308280009 hasAuthorship W4308280009A5045366083 @default.
• W4308280009 hasAuthorship W4308280009A5048758770 @default.
• W4308280009 hasAuthorship W4308280009A5056996972 @default.
• W4308280009 hasAuthorship W4308280009A5059563268 @default.
• W4308280009 hasAuthorship W4308280009A5076769610 @default.
• W4308280009 hasAuthorship W4308280009A5080652620 @default.
• W4308280009 hasAuthorship W4308280009A5089245484 @default.
• W4308280009 hasAuthorship W4308280009A5091804533 @default.
• W4308280009 hasBestOaLocation W43082800091 @default.
• W4308280009 hasConcept C104317684 @default.
• W4308280009 hasConcept C127716648 @default.
• W4308280009 hasConcept C148738053 @default.
• W4308280009 hasConcept C1491633281 @default.
• W4308280009 hasConcept C150194340 @default.
• W4308280009 hasConcept C162317418 @default.
• W4308280009 hasConcept C201750760 @default.
• W4308280009 hasConcept C28328180 @default.
• W4308280009 hasConcept C54355233 @default.
• W4308280009 hasConcept C85813293 @default.
• W4308280009 hasConcept C86339819 @default.

• next