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- W4308289936 abstract "Pirfenidone (PRF), the first FDA-approved drug to treat idiopathic pulmonary fibrosis (IPF) and formulated as an oral dosage form, has many side effects. To enhance the therapeutic effect, we discovered a high-load nanoemulsion using a novel deep eutectic solvent (DES) and developed an inhalation drug with improved bioavailability. The DES of PRF and N-acetylcysteine were discovered, and their physicochemical properties were evaluated in this study. The mechanism of DES formation was confirmed by FT-IR and 1H NMR and suggested to involve hydrogen bonding. The DES nanoemulsion in which the nano-sized droplets were dispersed is optimized by mixing the DES and distilled water in a ratio. The in vivo pharmacokinetic study showed that the pulmonary route of administration is superior to that of the oral route, and the DES nanoemulsion is superior to that of the PRF solution in achieving better bioavailability and lung distribution. The therapeutic effect of PRF for IPF could be confirmed through in vivo pharmacodynamics studies, including lung function assessment, enzyme-linked immunosorbent assay, histology, and micro-computed tomography using the bleomycin-induced IPF rat model. In addition, the pulmonary route administration of PRF is advantageous in reducing the toxicity risk." @default.
- W4308289936 created "2022-11-10" @default.
- W4308289936 creator A5026190297 @default.
- W4308289936 creator A5031098802 @default.
- W4308289936 creator A5032519788 @default.
- W4308289936 creator A5039865601 @default.
- W4308289936 creator A5089543677 @default.
- W4308289936 date "2022-12-01" @default.
- W4308289936 modified "2023-10-15" @default.
- W4308289936 title "Inhaled deep eutectic solvent based-nanoemulsion of pirfenidone in idiopathic pulmonary fibrosis" @default.
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- W4308289936 doi "https://doi.org/10.1016/j.jconrel.2022.10.045" @default.
- W4308289936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36341935" @default.
- W4308289936 hasPublicationYear "2022" @default.
- W4308289936 type Work @default.