FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308294015> ?p ?o ?g. }

• W4308294015 endingPage "46" @default.
• W4308294015 startingPage "36" @default.
• W4308294015 abstract "Bisphosphoglycerate mutase (BPGM) is expressed in human erythrocytes and responsible for the production of 2,3-bisphosphoglycerate (2,3-DPG). However, the expression and role of BPGM in other cells have not been reported. In this work, we found that BPGM was significantly upregulated in astrocytes upon acute hypoxia, and the role of this phenomenon will be clarified in the following report.The mRNA and protein expression levels of BPGM and the content of 2,3-DPG with hypoxia treatment were determined in vitro and in vivo. Furthermore, glycolysis was evaluated upon in hypoxic astrocytes with BPGM knockdown and in normoxic astrocytes with BPGM overexpression or 2,3-DPG treatment. To investigate the mechanism by which BPGM/2,3-DPG regulated glycolysis in hypoxic astrocytes, we detected the expression of HIF-1α, FIH-1 and TET2 with silencing or overexpression of BPGM and 2,3-DPG treatment.The expression of glycolytic genes and the capacity of lactate markedly increased with 6 h, 12 h, 24 h, 36 h and 48 h 1 % O2 hypoxic treatment in astrocytes. The expression of BPGM was upregulated, and the production of 2,3-DPG was accelerated upon hypoxia. Moreover, when BPGM expression was knocked down, glycolysis was promoted in HEB cells. However, overexpression of BPGM and addition of 2,3-DPG to the cellular medium in normoxic cells could downregulate glycolytic genes. Furthermore, HIF-1α and TET2 exhibited higher expression levels and FIH-1 showed a lower expression level upon BPGM silencing, while these changes were reversed under BPGM overexpression and 2,3-DPG treatment.Our study revealed that the BPGM/2,3-DPG pathway presented a suppressive effect on glycolysis in hypoxic astrocytes by negatively regulating HIF-1α and TET2." @default.
• W4308294015 created "2022-11-10" @default.
• W4308294015 creator A5001839890 @default.
• W4308294015 creator A5005627824 @default.
• W4308294015 creator A5020144184 @default.
• W4308294015 creator A5022883801 @default.
• W4308294015 creator A5035419929 @default.
• W4308294015 creator A5035818958 @default.
• W4308294015 creator A5039403729 @default.
• W4308294015 creator A5048398884 @default.
• W4308294015 creator A5052812929 @default.
• W4308294015 creator A5060129243 @default.
• W4308294015 creator A5079594267 @default.
• W4308294015 creator A5080525662 @default.
• W4308294015 date "2023-01-01" @default.
• W4308294015 modified "2023-10-01" @default.
• W4308294015 title "Enhanced BPGM/2,3-DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH-1 and TET2" @default.
• W4308294015 cites W1782905264 @default.
• W4308294015 cites W1888762249 @default.
• W4308294015 cites W1968829729 @default.
• W4308294015 cites W1975984062 @default.
• W4308294015 cites W1980650269 @default.
• W4308294015 cites W1990216374 @default.
• W4308294015 cites W1993642596 @default.
• W4308294015 cites W2005512795 @default.
• W4308294015 cites W2017964197 @default.
• W4308294015 cites W2029755755 @default.
• W4308294015 cites W2033958147 @default.
• W4308294015 cites W2055168645 @default.
• W4308294015 cites W2065802840 @default.
• W4308294015 cites W2075575138 @default.
• W4308294015 cites W2084233723 @default.
• W4308294015 cites W2090316209 @default.
• W4308294015 cites W2101084498 @default.
• W4308294015 cites W2105536017 @default.
• W4308294015 cites W2110429413 @default.
• W4308294015 cites W2111786117 @default.
• W4308294015 cites W2118336842 @default.
• W4308294015 cites W2131545700 @default.
• W4308294015 cites W2210628912 @default.
• W4308294015 cites W2278495018 @default.
• W4308294015 cites W2293679413 @default.
• W4308294015 cites W2339357064 @default.
• W4308294015 cites W2472577550 @default.
• W4308294015 cites W2498411827 @default.
• W4308294015 cites W2515863781 @default.
• W4308294015 cites W2550545243 @default.
• W4308294015 cites W2596602988 @default.
• W4308294015 cites W2743496055 @default.
• W4308294015 cites W2767022103 @default.
• W4308294015 cites W2767539665 @default.
• W4308294015 cites W2901093770 @default.
• W4308294015 cites W2904263028 @default.
• W4308294015 cites W2910794020 @default.
• W4308294015 cites W2937118695 @default.
• W4308294015 cites W2946373463 @default.
• W4308294015 cites W2960448134 @default.
• W4308294015 cites W2962710423 @default.
• W4308294015 cites W2987973693 @default.
• W4308294015 cites W3009049614 @default.
• W4308294015 cites W3013914363 @default.
• W4308294015 cites W3021527459 @default.
• W4308294015 cites W3041337213 @default.
• W4308294015 cites W3042931248 @default.
• W4308294015 cites W3081944088 @default.
• W4308294015 cites W3095995869 @default.
• W4308294015 cites W3098524589 @default.
• W4308294015 cites W3111770876 @default.
• W4308294015 cites W3178569557 @default.
• W4308294015 cites W3186188872 @default.
• W4308294015 cites W3196588292 @default.
• W4308294015 cites W3197840181 @default.
• W4308294015 cites W4200432797 @default.
• W4308294015 cites W4210542920 @default.
• W4308294015 cites W47016903 @default.
• W4308294015 doi "https://doi.org/10.1016/j.brainresbull.2022.11.002" @default.
• W4308294015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36334804" @default.
• W4308294015 hasPublicationYear "2023" @default.
• W4308294015 type Work @default.
• W4308294015 citedByCount "0" @default.
• W4308294015 crossrefType "journal-article" @default.
• W4308294015 hasAuthorship W4308294015A5001839890 @default.
• W4308294015 hasAuthorship W4308294015A5005627824 @default.
• W4308294015 hasAuthorship W4308294015A5020144184 @default.
• W4308294015 hasAuthorship W4308294015A5022883801 @default.
• W4308294015 hasAuthorship W4308294015A5035419929 @default.
• W4308294015 hasAuthorship W4308294015A5035818958 @default.
• W4308294015 hasAuthorship W4308294015A5039403729 @default.
• W4308294015 hasAuthorship W4308294015A5048398884 @default.
• W4308294015 hasAuthorship W4308294015A5052812929 @default.
• W4308294015 hasAuthorship W4308294015A5060129243 @default.
• W4308294015 hasAuthorship W4308294015A5079594267 @default.
• W4308294015 hasAuthorship W4308294015A5080525662 @default.
• W4308294015 hasBestOaLocation W43082940151 @default.
• W4308294015 hasConcept C104317684 @default.
• W4308294015 hasConcept C105580179 @default.
• W4308294015 hasConcept C119056186 @default.
• W4308294015 hasConcept C127561419 @default.

• next