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• W4308294089 abstract "Background: Traditional cardiovascular risk factors and the underlying genetic risk of elevated blood pressure (BP) determine an individual’s composite risk of developing adverse cardiovascular events. We sought to evaluate the relative contributions of the traditional cardiovascular risk factors to the development of adverse cardiovascular events in the context of varying BP genetic risk profiles. Methods: Genome-wide polygenic risk score (PRS) was computed using multiancestry genome-wide association estimates among US adults who underwent whole-genome sequencing in the Trans-Omics for Precision program. Individuals were stratified into high, intermediate, and low genetic risk groups (>80th, 20–80th, and <20th centiles of systolic BP [SBP] PRS). Based on the ACC/AHA Pooled Cohort Equations, participants were stratified into low and high (10 year-atherosclerotic cardiovascular disease [CVD] risk: <10% or ≥10%) cardiovascular risk factor profile groups. The primary study outcome was incident cardiovascular event (composite of incident heart failure, incident stroke, and incident coronary heart disease). Results: Among 21 897 US adults (median age: 56 years; 56.0% women; 35.8% non-White race/ethnicity), 1 SD increase in the SBP PRS, computed using 1.08 million variants, was associated with SBP (β: 4.39 [95% CI, 4.13–4.65]) and hypertension (odds ratio, 1.50 [95% CI, 1.46–1.55]), respectively. This association was robustly seen across racial/ethnic groups. Each SD increase in SBP PRS was associated with a higher risk of the incident CVD (multivariable-adjusted hazards ratio, 1.07 [95% CI, 1.04–1.10]) after controlling for ACC/AHA Pooled Cohort Equations risk scores. Among individuals with a high SBP PRS, low atherosclerotic CVD risk was associated with a 58% lower hazard for incident CVD (multivariable-adjusted hazards ratio, 0.42 [95% CI, 0.36–0.50]) compared to those with high atherosclerotic CVD risk. A similar pattern was noted in intermediate and low genetic risk groups. Conclusions: In a multiancestry cohort of >21 000 US adults, genome-wide SBP PRS was associated with BP traits and adverse cardiovascular events. Adequate control of modifiable cardiovascular risk factors may reduce the predisposition to adverse cardiovascular events among those with a high SBP PRS." @default.
• W4308294089 created "2022-11-10" @default.
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• W4308294089 date "2022-12-01" @default.
• W4308294089 modified "2023-09-30" @default.
• W4308294089 title "Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events" @default.
• W4308294089 cites W1510259645 @default.
• W4308294089 cites W1617145133 @default.
• W4308294089 cites W172609984 @default.
• W4308294089 cites W1809577636 @default.
• W4308294089 cites W1844405070 @default.
• W4308294089 cites W1975271432 @default.
• W4308294089 cites W1999908627 @default.
• W4308294089 cites W2010579338 @default.
• W4308294089 cites W2025514270 @default.
• W4308294089 cites W2033896043 @default.
• W4308294089 cites W2037580369 @default.
• W4308294089 cites W2044702943 @default.
• W4308294089 cites W2063131612 @default.
• W4308294089 cites W2065604182 @default.
• W4308294089 cites W2074847887 @default.
• W4308294089 cites W2084139018 @default.
• W4308294089 cites W2101605059 @default.
• W4308294089 cites W2112316706 @default.
• W4308294089 cites W2126388596 @default.
• W4308294089 cites W2156097706 @default.
• W4308294089 cites W2157788171 @default.
• W4308294089 cites W2161197885 @default.
• W4308294089 cites W2168536722 @default.
• W4308294089 cites W2394084479 @default.
• W4308294089 cites W2507528355 @default.
• W4308294089 cites W2549881333 @default.
• W4308294089 cites W2584280654 @default.
• W4308294089 cites W2587778246 @default.
• W4308294089 cites W2587966986 @default.
• W4308294089 cites W2596239528 @default.
• W4308294089 cites W2599627323 @default.
• W4308294089 cites W2731507867 @default.
• W4308294089 cites W2733756507 @default.
• W4308294089 cites W2736297853 @default.
• W4308294089 cites W2770837559 @default.
• W4308294089 cites W2777641772 @default.
• W4308294089 cites W2782879502 @default.
• W4308294089 cites W2800611838 @default.
• W4308294089 cites W2801098573 @default.
• W4308294089 cites W2801486783 @default.
• W4308294089 cites W2883415719 @default.
• W4308294089 cites W2886752110 @default.
• W4308294089 cites W2921012991 @default.
• W4308294089 cites W2951553270 @default.
• W4308294089 cites W2973113902 @default.
• W4308294089 cites W2995302941 @default.
• W4308294089 cites W3007698544 @default.
• W4308294089 cites W3008788084 @default.
• W4308294089 cites W3016201840 @default.
• W4308294089 cites W3017979401 @default.
• W4308294089 cites W3040608858 @default.
• W4308294089 cites W3045441625 @default.
• W4308294089 cites W3083258151 @default.
• W4308294089 cites W3083975636 @default.
• W4308294089 cites W3103577858 @default.
• W4308294089 cites W3112624009 @default.
• W4308294089 cites W3116105976 @default.
• W4308294089 cites W3126160703 @default.
• W4308294089 cites W3126167614 @default.
• W4308294089 cites W3130996005 @default.
• W4308294089 cites W3135780366 @default.
• W4308294089 cites W3139974943 @default.
• W4308294089 cites W3143437408 @default.
• W4308294089 cites W3153616883 @default.
• W4308294089 cites W3165429330 @default.
• W4308294089 cites W3172996796 @default.
• W4308294089 cites W3175292656 @default.
• W4308294089 cites W3185660997 @default.
• W4308294089 cites W3193823764 @default.
• W4308294089 cites W3198774792 @default.
• W4308294089 cites W3205644245 @default.
• W4308294089 cites W3217131706 @default.
• W4308294089 cites W4205170775 @default.
• W4308294089 cites W4213133405 @default.
• W4308294089 cites W4223951741 @default.
• W4308294089 cites W4223991858 @default.
• W4308294089 cites W4226225611 @default.
• W4308294089 cites W4239096779 @default.
• W4308294089 cites W4283206544 @default.
• W4308294089 cites W4290839014 @default.
• W4308294089 doi "https://doi.org/10.1161/circgen.122.003946" @default.
• W4308294089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36334310" @default.

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