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- W4308294265 endingPage "100805" @default.
- W4308294265 startingPage "100805" @default.
- W4308294265 abstract "Coronary artery disease (CAD) is a leading cause of death in patients with systemic lupus erythematosus (SLE). Despite clinical evidence supporting an association between SLE and CAD, pleiotropy-adjusted genetic association studies are limited and focus on only a few common risk loci. Here, we identify a net positive causal estimate of SLE-associated non-HLA SNPs on CAD by traditional Mendelian randomization (MR) approaches. Pathway analysis using SNP-to-gene mapping followed by unsupervised clustering based on protein-protein interactions (PPIs) identifies biological networks composed of positive and negative causal sets of genes. In addition, we confirm the casual effects of specific SNP-to-gene modules on CAD using only SNP mapping to each PPI-defined functional gene set as instrumental variables. This PPI-based MR approach elucidates various molecular pathways with causal implications between SLE and CAD and identifies biological pathways likely causative of both pathologies, revealing known and novel therapeutic interventions for managing CAD in SLE." @default.
- W4308294265 created "2022-11-10" @default.
- W4308294265 creator A5021939953 @default.
- W4308294265 creator A5022606544 @default.
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- W4308294265 creator A5043874873 @default.
- W4308294265 creator A5056798668 @default.
- W4308294265 date "2022-11-01" @default.
- W4308294265 modified "2023-09-26" @default.
- W4308294265 title "Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease" @default.
- W4308294265 cites W1606361567 @default.
- W4308294265 cites W1844405070 @default.
- W4308294265 cites W1889972874 @default.
- W4308294265 cites W1904135384 @default.
- W4308294265 cites W1985778164 @default.
- W4308294265 cites W1997390762 @default.
- W4308294265 cites W2007287574 @default.
- W4308294265 cites W2010160850 @default.
- W4308294265 cites W2018838463 @default.
- W4308294265 cites W2023785526 @default.
- W4308294265 cites W2030457230 @default.
- W4308294265 cites W2031081696 @default.
- W4308294265 cites W2031580483 @default.
- W4308294265 cites W2070040136 @default.
- W4308294265 cites W2070050178 @default.
- W4308294265 cites W2070777085 @default.
- W4308294265 cites W2073167340 @default.
- W4308294265 cites W2073839280 @default.
- W4308294265 cites W2076735703 @default.
- W4308294265 cites W2082829053 @default.
- W4308294265 cites W2089151341 @default.
- W4308294265 cites W2097419183 @default.
- W4308294265 cites W2097791641 @default.
- W4308294265 cites W2110274269 @default.
- W4308294265 cites W2112543488 @default.
- W4308294265 cites W2112848098 @default.
- W4308294265 cites W2119763916 @default.
- W4308294265 cites W2128313682 @default.
- W4308294265 cites W2130077869 @default.
- W4308294265 cites W2138102919 @default.
- W4308294265 cites W2139011450 @default.
- W4308294265 cites W2147086116 @default.
- W4308294265 cites W2149063533 @default.
- W4308294265 cites W2156157712 @default.
- W4308294265 cites W2156543902 @default.
- W4308294265 cites W2159675211 @default.
- W4308294265 cites W2163749231 @default.
- W4308294265 cites W2166593999 @default.
- W4308294265 cites W2195783463 @default.
- W4308294265 cites W2211185698 @default.
- W4308294265 cites W2238851414 @default.
- W4308294265 cites W2267505920 @default.
- W4308294265 cites W2293423772 @default.
- W4308294265 cites W2338966394 @default.
- W4308294265 cites W2398690791 @default.
- W4308294265 cites W2417483443 @default.
- W4308294265 cites W2474656875 @default.
- W4308294265 cites W2581452190 @default.
- W4308294265 cites W2619767973 @default.
- W4308294265 cites W2724719188 @default.
- W4308294265 cites W2734534935 @default.
- W4308294265 cites W2753055890 @default.
- W4308294265 cites W2768977980 @default.
- W4308294265 cites W2775393828 @default.
- W4308294265 cites W2791310791 @default.
- W4308294265 cites W2791863121 @default.
- W4308294265 cites W2793127599 @default.
- W4308294265 cites W2794134966 @default.
- W4308294265 cites W2799624238 @default.
- W4308294265 cites W2800369384 @default.
- W4308294265 cites W2805983714 @default.
- W4308294265 cites W2807529610 @default.
- W4308294265 cites W2808724535 @default.
- W4308294265 cites W2884743521 @default.
- W4308294265 cites W2891907769 @default.
- W4308294265 cites W2892479680 @default.
- W4308294265 cites W2904379191 @default.
- W4308294265 cites W2941878796 @default.
- W4308294265 cites W2955177623 @default.
- W4308294265 cites W2958502619 @default.
- W4308294265 cites W2980012755 @default.
- W4308294265 cites W2981577500 @default.
- W4308294265 cites W2992135626 @default.
- W4308294265 cites W3032192961 @default.
- W4308294265 cites W3033370901 @default.
- W4308294265 cites W3083896917 @default.
- W4308294265 cites W3092067005 @default.
- W4308294265 cites W3093045028 @default.
- W4308294265 cites W3097649601 @default.
- W4308294265 cites W3107527779 @default.
- W4308294265 cites W3126364712 @default.
- W4308294265 cites W3126809340 @default.
- W4308294265 cites W3127363824 @default.
- W4308294265 cites W3152985338 @default.
- W4308294265 cites W3155898439 @default.
- W4308294265 cites W3201634098 @default.
- W4308294265 doi "https://doi.org/10.1016/j.xcrm.2022.100805" @default.