FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308297827> ?p ?o ?g. }

• W4308297827 endingPage "121145" @default.
• W4308297827 startingPage "121145" @default.
• W4308297827 abstract "We compared the efficacy of n3-polyunsaturated fatty acids (n3-PUFAs) and metformin in halting the progression of non-alcoholic fatty liver disease (NAFLD) developed in the milieu of insulin deficiency.NAFLD was induced by a chronic high-fat diet (HFD) in male Sprague Dawley rats, rendered diabetic by a low dose streptozotocin (STZ). Diabetic rats were treated with n3-PUFAs (300 mg/kg/d) or metformin (150 mg/kg/d) for 8 weeks. Improvements in the NAFLD score and hepatic insulin resistance (IR) were addressed and correlated to changes in the hepatic expression of Forkhead box protein O1 (FOXO-1), microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) and gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) genes. Hepatic peroxisome proliferator-activated receptor alpha (PPAR-α), and B-cell lymphoma 2 (Bcl-2) protein expression was also assessed.Driven by insulin deficiency and HFD, the FOXO-1 gene along with its downstream targets, MAP1LC3B and GABARAPL1, were highly expressed in the liver tissue of the HFD/STZ group. Meanwhile, hepatic expression of PPAR-α and Bcl-2 was markedly decreased. These abnormalities coincided with a marked increase in the hepatic IR and NAFLD activity. Comparable to metformin, n3-PUFAs were able to rearrange hepatic PPAR-α and FOXO-1 expression in HFD/STZ rats, resulting in improved diabetic/steatotic liver phenotype.Along with the enhancement of PPAR-α expression, inhibition of FoxO1/GABARAPL1/MAP1LC3B transcription is suggested as a core mechanism for the protective effects of n3-PUFAs on hepatic IR and NAFLD. Under conditions of insulin deficiency, n3-PUFAs retain their potential as a safe and promising approach for the control of NAFLD." @default.
• W4308297827 created "2022-11-10" @default.
• W4308297827 creator A5003274304 @default.
• W4308297827 creator A5012822338 @default.
• W4308297827 creator A5043667536 @default.
• W4308297827 creator A5049058422 @default.
• W4308297827 creator A5064163988 @default.
• W4308297827 date "2022-12-01" @default.
• W4308297827 modified "2023-10-03" @default.
• W4308297827 title "The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway" @default.
• W4308297827 cites W1594600577 @default.
• W4308297827 cites W1804718109 @default.
• W4308297827 cites W1978113489 @default.
• W4308297827 cites W1982479748 @default.
• W4308297827 cites W1987055732 @default.
• W4308297827 cites W1987522063 @default.
• W4308297827 cites W1991462470 @default.
• W4308297827 cites W1998112404 @default.
• W4308297827 cites W1998873257 @default.
• W4308297827 cites W2004922828 @default.
• W4308297827 cites W2007743440 @default.
• W4308297827 cites W2009010832 @default.
• W4308297827 cites W2014622450 @default.
• W4308297827 cites W2023838856 @default.
• W4308297827 cites W2025139842 @default.
• W4308297827 cites W2035816889 @default.
• W4308297827 cites W2045653720 @default.
• W4308297827 cites W2054016219 @default.
• W4308297827 cites W2056766695 @default.
• W4308297827 cites W2073956836 @default.
• W4308297827 cites W2073963703 @default.
• W4308297827 cites W2078329315 @default.
• W4308297827 cites W2084697100 @default.
• W4308297827 cites W2093160045 @default.
• W4308297827 cites W2099540110 @default.
• W4308297827 cites W2100171908 @default.
• W4308297827 cites W2104680689 @default.
• W4308297827 cites W2113717007 @default.
• W4308297827 cites W2126327417 @default.
• W4308297827 cites W2136229559 @default.
• W4308297827 cites W2141231160 @default.
• W4308297827 cites W2143712285 @default.
• W4308297827 cites W2144221481 @default.
• W4308297827 cites W2152602200 @default.
• W4308297827 cites W2153553562 @default.
• W4308297827 cites W2154249505 @default.
• W4308297827 cites W2157267807 @default.
• W4308297827 cites W2163837156 @default.
• W4308297827 cites W2166165585 @default.
• W4308297827 cites W2167279371 @default.
• W4308297827 cites W2170050558 @default.
• W4308297827 cites W2199491407 @default.
• W4308297827 cites W2315858463 @default.
• W4308297827 cites W2396599931 @default.
• W4308297827 cites W2508534437 @default.
• W4308297827 cites W2605808009 @default.
• W4308297827 cites W2735867008 @default.
• W4308297827 cites W2759997926 @default.
• W4308297827 cites W2766185642 @default.
• W4308297827 cites W2770872625 @default.
• W4308297827 cites W2793646955 @default.
• W4308297827 cites W2899043265 @default.
• W4308297827 cites W3011537607 @default.
• W4308297827 cites W3033917549 @default.
• W4308297827 cites W3036732739 @default.
• W4308297827 cites W3080093778 @default.
• W4308297827 cites W3092713577 @default.
• W4308297827 cites W3137657841 @default.
• W4308297827 cites W3139416446 @default.
• W4308297827 cites W3183146269 @default.
• W4308297827 cites W3193976289 @default.
• W4308297827 cites W3215301353 @default.
• W4308297827 cites W4214536418 @default.
• W4308297827 cites W4220908736 @default.
• W4308297827 cites W4281892643 @default.
• W4308297827 cites W4283661091 @default.
• W4308297827 doi "https://doi.org/10.1016/j.lfs.2022.121145" @default.
• W4308297827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336129" @default.
• W4308297827 hasPublicationYear "2022" @default.
• W4308297827 type Work @default.
• W4308297827 citedByCount "2" @default.
• W4308297827 countsByYear W43082978272023 @default.
• W4308297827 crossrefType "journal-article" @default.
• W4308297827 hasAuthorship W4308297827A5003274304 @default.
• W4308297827 hasAuthorship W4308297827A5012822338 @default.
• W4308297827 hasAuthorship W4308297827A5043667536 @default.
• W4308297827 hasAuthorship W4308297827A5049058422 @default.
• W4308297827 hasAuthorship W4308297827A5064163988 @default.
• W4308297827 hasConcept C104317684 @default.
• W4308297827 hasConcept C112446052 @default.
• W4308297827 hasConcept C126322002 @default.
• W4308297827 hasConcept C134018914 @default.
• W4308297827 hasConcept C140149449 @default.
• W4308297827 hasConcept C170493617 @default.
• W4308297827 hasConcept C185592680 @default.
• W4308297827 hasConcept C187345961 @default.
• W4308297827 hasConcept C188413054 @default.
• W4308297827 hasConcept C190283241 @default.

• next