Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308303839> ?p ?o ?g. }
- W4308303839 abstract "Abstract Multiple sclerosis (MS) is a prototypic chronic-inflammatory disease of the central nervous system. After initial lesion formation during active demyelination, inflammation is gradually compartmentalized and restricted to specific tissue areas such as the lesion rim in chronic-active lesions. However, the cell type-specific and spatially restricted drivers of chronic tissue damage and lesion expansion are not well understood. Here, we investigated the properties of subcortical white matter lesions by creating a cell type-specific spatial map of gene expression across various inflammatory lesion stages in MS. An integrated analysis of single-nucleus and spatial transcriptomics data enabled us to uncover patterns of glial, immune and stromal cell subtype diversity, as well as to identify cell-cell communication and signaling signatures across lesion and non-lesion tissue areas in MS. Our results provide insights into the conversion of the tissue microenvironment from a ‘homeostatic’ to a pathogenic or ‘dysfunctional’ state underlying lesion progression in MS. We expect that this study will help identify spatially resolved cell type-specific biomarkers and therapeutic targets for future interventional trials in MS." @default.
- W4308303839 created "2022-11-10" @default.
- W4308303839 creator A5005499510 @default.
- W4308303839 creator A5019418182 @default.
- W4308303839 creator A5036198068 @default.
- W4308303839 creator A5037274841 @default.
- W4308303839 creator A5050279683 @default.
- W4308303839 creator A5052382826 @default.
- W4308303839 creator A5059284966 @default.
- W4308303839 creator A5059775841 @default.
- W4308303839 creator A5070184232 @default.
- W4308303839 creator A5075643718 @default.
- W4308303839 creator A5076702152 @default.
- W4308303839 creator A5080885177 @default.
- W4308303839 creator A5085207320 @default.
- W4308303839 creator A5089717149 @default.
- W4308303839 creator A5090010970 @default.
- W4308303839 creator A5091649525 @default.
- W4308303839 date "2022-11-03" @default.
- W4308303839 modified "2023-10-06" @default.
- W4308303839 title "Spatial cell type mapping of multiple sclerosis lesions" @default.
- W4308303839 cites W1578762211 @default.
- W4308303839 cites W1742765381 @default.
- W4308303839 cites W1763205699 @default.
- W4308303839 cites W1973101671 @default.
- W4308303839 cites W1975434091 @default.
- W4308303839 cites W1998466946 @default.
- W4308303839 cites W1999952543 @default.
- W4308303839 cites W2007128839 @default.
- W4308303839 cites W2009308901 @default.
- W4308303839 cites W2010457001 @default.
- W4308303839 cites W2017070092 @default.
- W4308303839 cites W2031502025 @default.
- W4308303839 cites W2061344523 @default.
- W4308303839 cites W2067200113 @default.
- W4308303839 cites W2081215035 @default.
- W4308303839 cites W2101520046 @default.
- W4308303839 cites W2111428020 @default.
- W4308303839 cites W2114319271 @default.
- W4308303839 cites W2124364681 @default.
- W4308303839 cites W2125281412 @default.
- W4308303839 cites W2129134090 @default.
- W4308303839 cites W2130974415 @default.
- W4308303839 cites W2147062889 @default.
- W4308303839 cites W2148353419 @default.
- W4308303839 cites W2273220492 @default.
- W4308303839 cites W2306855134 @default.
- W4308303839 cites W2316852351 @default.
- W4308303839 cites W2339698996 @default.
- W4308303839 cites W2419062639 @default.
- W4308303839 cites W2468501494 @default.
- W4308303839 cites W2482717739 @default.
- W4308303839 cites W2489242797 @default.
- W4308303839 cites W2506906012 @default.
- W4308303839 cites W2542350582 @default.
- W4308303839 cites W2562977489 @default.
- W4308303839 cites W2565958526 @default.
- W4308303839 cites W2572710398 @default.
- W4308303839 cites W2587838788 @default.
- W4308303839 cites W2592213450 @default.
- W4308303839 cites W2608003033 @default.
- W4308303839 cites W2754890392 @default.
- W4308303839 cites W2766890970 @default.
- W4308303839 cites W2800392236 @default.
- W4308303839 cites W2805197831 @default.
- W4308303839 cites W2817838603 @default.
- W4308303839 cites W2890865075 @default.
- W4308303839 cites W2895663716 @default.
- W4308303839 cites W2909217338 @default.
- W4308303839 cites W2911725378 @default.
- W4308303839 cites W2951560273 @default.
- W4308303839 cites W2952391626 @default.
- W4308303839 cites W2964315448 @default.
- W4308303839 cites W2967069002 @default.
- W4308303839 cites W2971747983 @default.
- W4308303839 cites W2980870655 @default.
- W4308303839 cites W2984472267 @default.
- W4308303839 cites W3000187202 @default.
- W4308303839 cites W3025060349 @default.
- W4308303839 cites W3044511747 @default.
- W4308303839 cites W3048044439 @default.
- W4308303839 cites W3080402156 @default.
- W4308303839 cites W3083733923 @default.
- W4308303839 cites W3106188259 @default.
- W4308303839 cites W3124374877 @default.
- W4308303839 cites W3130478359 @default.
- W4308303839 cites W3135648969 @default.
- W4308303839 cites W3138055079 @default.
- W4308303839 cites W3158248679 @default.
- W4308303839 cites W3167041060 @default.
- W4308303839 cites W3197136220 @default.
- W4308303839 cites W4205817967 @default.
- W4308303839 cites W4214876469 @default.
- W4308303839 cites W4225329254 @default.
- W4308303839 cites W4225491855 @default.
- W4308303839 cites W4253381763 @default.
- W4308303839 cites W4281716326 @default.
- W4308303839 cites W4282927829 @default.
- W4308303839 cites W4296028489 @default.
- W4308303839 cites W4306410343 @default.