Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308304023> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4308304023 abstract "Abstract The present study was aimed to develop compression coated tablets of diclofenac sodium (75mg) in the inner core and misoprostol (200 mg) as the outer shell for the effective treatment of rheumatoid arthritis as this dosing frequency is not available in the market yet. Diclofenac sodium inner tablet was manufactured by wet granulation and its enteric coating was applied by Eudragit L 100-55, Isopropyl Alcohol and Opadry II Blue 85 F205034. While immediate-release misoprostol outer shell was also manufactured by wet granulation and coated by Opadry white and Polyethylene glycol 6000. Design of experiment ® software was used for formulation design and optimization. Quality attributes such as tablet weight, hardness, disintegration time, percent drug dissolution and assay were performed as per official methods and satisfactory results were reported. Physical and chemical stability of selected formulations was evaluated following the ICH guidelines for accelerated stability testing. The compressional analysis of optimized formulation was performed to check the optimum compression pressure to obtain a stable formulation. Based on satisfactory quality attributes; formulation DF9MF7 was successfully developed as compression coated tablet with calculated shelf life of 4.8years. Compression coated tablets comprising of enteric coated diclofenac sodium as inner core and misoprostol as outer shell were successfully developed by wet granulation." @default.
- W4308304023 created "2022-11-10" @default.
- W4308304023 creator A5015690119 @default.
- W4308304023 creator A5021713683 @default.
- W4308304023 creator A5022094595 @default.
- W4308304023 creator A5029190746 @default.
- W4308304023 creator A5040388154 @default.
- W4308304023 creator A5062987780 @default.
- W4308304023 creator A5076141587 @default.
- W4308304023 date "2022-11-05" @default.
- W4308304023 modified "2023-10-17" @default.
- W4308304023 title "Design And Optimization Studies Of Tablet In Tablet Formulation Of Diclofenac And Misoprostol: Application Of Response Surface Methodology And Compressional Behaviour Strategy" @default.
- W4308304023 cites W1595974579 @default.
- W4308304023 cites W1705669817 @default.
- W4308304023 cites W1823298943 @default.
- W4308304023 cites W1964729739 @default.
- W4308304023 cites W1968414118 @default.
- W4308304023 cites W1972888396 @default.
- W4308304023 cites W2038410983 @default.
- W4308304023 cites W2050228113 @default.
- W4308304023 cites W2067145242 @default.
- W4308304023 cites W2082670217 @default.
- W4308304023 cites W2115139125 @default.
- W4308304023 cites W2760977109 @default.
- W4308304023 cites W3000204431 @default.
- W4308304023 cites W3006023775 @default.
- W4308304023 cites W3043909020 @default.
- W4308304023 cites W3110470998 @default.
- W4308304023 cites W355643970 @default.
- W4308304023 cites W4242183880 @default.
- W4308304023 doi "https://doi.org/10.1101/2022.11.04.515246" @default.
- W4308304023 hasPublicationYear "2022" @default.
- W4308304023 type Work @default.
- W4308304023 citedByCount "0" @default.
- W4308304023 crossrefType "posted-content" @default.
- W4308304023 hasAuthorship W4308304023A5015690119 @default.
- W4308304023 hasAuthorship W4308304023A5021713683 @default.
- W4308304023 hasAuthorship W4308304023A5022094595 @default.
- W4308304023 hasAuthorship W4308304023A5029190746 @default.
- W4308304023 hasAuthorship W4308304023A5040388154 @default.
- W4308304023 hasAuthorship W4308304023A5062987780 @default.
- W4308304023 hasAuthorship W4308304023A5076141587 @default.
- W4308304023 hasBestOaLocation W43083040231 @default.
- W4308304023 hasConcept C136229726 @default.
- W4308304023 hasConcept C150077022 @default.
- W4308304023 hasConcept C159985019 @default.
- W4308304023 hasConcept C180016635 @default.
- W4308304023 hasConcept C185592680 @default.
- W4308304023 hasConcept C192562407 @default.
- W4308304023 hasConcept C2778642596 @default.
- W4308304023 hasConcept C2779199973 @default.
- W4308304023 hasConcept C2779234561 @default.
- W4308304023 hasConcept C2779826273 @default.
- W4308304023 hasConcept C2908765736 @default.
- W4308304023 hasConcept C43617362 @default.
- W4308304023 hasConcept C54355233 @default.
- W4308304023 hasConcept C71924100 @default.
- W4308304023 hasConcept C77281830 @default.
- W4308304023 hasConcept C86803240 @default.
- W4308304023 hasConcept C88463166 @default.
- W4308304023 hasConcept C98274493 @default.
- W4308304023 hasConceptScore W4308304023C136229726 @default.
- W4308304023 hasConceptScore W4308304023C150077022 @default.
- W4308304023 hasConceptScore W4308304023C159985019 @default.
- W4308304023 hasConceptScore W4308304023C180016635 @default.
- W4308304023 hasConceptScore W4308304023C185592680 @default.
- W4308304023 hasConceptScore W4308304023C192562407 @default.
- W4308304023 hasConceptScore W4308304023C2778642596 @default.
- W4308304023 hasConceptScore W4308304023C2779199973 @default.
- W4308304023 hasConceptScore W4308304023C2779234561 @default.
- W4308304023 hasConceptScore W4308304023C2779826273 @default.
- W4308304023 hasConceptScore W4308304023C2908765736 @default.
- W4308304023 hasConceptScore W4308304023C43617362 @default.
- W4308304023 hasConceptScore W4308304023C54355233 @default.
- W4308304023 hasConceptScore W4308304023C71924100 @default.
- W4308304023 hasConceptScore W4308304023C77281830 @default.
- W4308304023 hasConceptScore W4308304023C86803240 @default.
- W4308304023 hasConceptScore W4308304023C88463166 @default.
- W4308304023 hasConceptScore W4308304023C98274493 @default.
- W4308304023 hasLocation W43083040231 @default.
- W4308304023 hasOpenAccess W4308304023 @default.
- W4308304023 hasPrimaryLocation W43083040231 @default.
- W4308304023 hasRelatedWork W2008993336 @default.
- W4308304023 hasRelatedWork W2026529261 @default.
- W4308304023 hasRelatedWork W2160098758 @default.
- W4308304023 hasRelatedWork W2184707645 @default.
- W4308304023 hasRelatedWork W2356251342 @default.
- W4308304023 hasRelatedWork W2470955411 @default.
- W4308304023 hasRelatedWork W2574536870 @default.
- W4308304023 hasRelatedWork W4200429643 @default.
- W4308304023 hasRelatedWork W4308304023 @default.
- W4308304023 hasRelatedWork W2184285324 @default.
- W4308304023 isParatext "false" @default.
- W4308304023 isRetracted "false" @default.
- W4308304023 workType "article" @default.