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- W4308304037 abstract "T cells expressing either alpha-beta or gamma-delta T cell receptors (TCR) are critical sentinels of the adaptive immune system, with receptor diversity being essential for protective immunity against a broad array of pathogens and agents. Programs available to profile TCR clonotypic signatures can be limiting for users with no coding expertise. Current analytical pipelines can be inefficient due to manual processing steps, open to data transcription errors and have multiple analytical tools with unique inputs that require coding expertise. Here we present a bespoke webtool designed for users irrespective of coding expertise, coined 'TCR_Explore', incorporating automated quality control steps that generates a single output file for creation of flexible and publication ready figures. TCR_Explore will elevate a user's capacity to undertake in-depth TCR repertoire analysis of both new and pre-existing datasets for identification of T cell clonotypes associated with health and disease. The web application is located at https://tcr-explore.erc.monash.edu for users to interactively explore TCR repertoire datasets." @default.
- W4308304037 created "2022-11-10" @default.
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- W4308304037 date "2022-11-04" @default.
- W4308304037 modified "2023-09-28" @default.
- W4308304037 title "TCR_Explore: a novel webtool for T cell receptor repertoire analysis" @default.
- W4308304037 doi "https://doi.org/10.1101/2022.11.03.514642" @default.
- W4308304037 hasPublicationYear "2022" @default.
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