FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308304623> ?p ?o ?g. }

• W4308304623 abstract "Abstract Background and Aims Nanoplastics (NPs) as contaminants in food and water have drawn an increasing public attention. However, little is known about how NPs shape the gut immune landscape after entering the body. The objective of the study was to explore indirect effects caused by the interaction of NPs with the mammalian gut and whole immune system after entering the body. Methods In this study, we fabricated NPs (∼500 nm) and microplastics (MPs) (∼2 μm) and aimed to evaluate their in vivo effects by feeding them in mice. The mechanism was then investigated by various technology including single-cell RNA sequencing of gut and brain tissue. Results The results suggested that NPs showed a better ability to induce gut macrophage activation than did MPs. In addition, NPs triggered gut interleukin 1 beta (IL-1β)-producing macrophage reprogramming via inducing lysosomal damage after phagocytosis. More importantly, IL-1β released from the intestine could affect brain immunity, leading to microglial activation and Th17 differentiation, all of which correlated with a decline in cognitive and short-term memory in NPs-fed mice Conclusions Thus, this study provides new insight into the mechanism of action of the gut-brain axis and delineates the way NPs reduce brain function, highlights the importance to fix the plastic pollution problem worldwide." @default.
• W4308304623 created "2022-11-10" @default.
• W4308304623 creator A5000728648 @default.
• W4308304623 creator A5004626333 @default.
• W4308304623 creator A5010776860 @default.
• W4308304623 creator A5030334202 @default.
• W4308304623 creator A5040558103 @default.
• W4308304623 creator A5055838753 @default.
• W4308304623 creator A5065113766 @default.
• W4308304623 creator A5067112955 @default.
• W4308304623 creator A5075489258 @default.
• W4308304623 creator A5077955809 @default.
• W4308304623 creator A5085910420 @default.
• W4308304623 date "2022-11-05" @default.
• W4308304623 modified "2023-09-29" @default.
• W4308304623 title "Oral Feeding of Nanoplastics reduces Brain function of Mice by Inducing Intestinal IL-1β-producing Macrophages" @default.
• W4308304623 cites W1670684017 @default.
• W4308304623 cites W1890993902 @default.
• W4308304623 cites W1994580609 @default.
• W4308304623 cites W2019952550 @default.
• W4308304623 cites W2043304167 @default.
• W4308304623 cites W2074185796 @default.
• W4308304623 cites W2114899816 @default.
• W4308304623 cites W2171083652 @default.
• W4308304623 cites W2290466312 @default.
• W4308304623 cites W2527872371 @default.
• W4308304623 cites W2912374833 @default.
• W4308304623 cites W2941165419 @default.
• W4308304623 cites W2948574679 @default.
• W4308304623 cites W2951730004 @default.
• W4308304623 cites W2965610524 @default.
• W4308304623 cites W3006300232 @default.
• W4308304623 cites W3044030235 @default.
• W4308304623 cites W3083692686 @default.
• W4308304623 cites W3111509171 @default.
• W4308304623 cites W3118771939 @default.
• W4308304623 cites W3174409529 @default.
• W4308304623 cites W3176667207 @default.
• W4308304623 cites W3205139696 @default.
• W4308304623 cites W4200267831 @default.
• W4308304623 cites W4238967548 @default.
• W4308304623 cites W4281616414 @default.
• W4308304623 cites W4284693043 @default.
• W4308304623 doi "https://doi.org/10.1101/2022.11.04.515261" @default.
• W4308304623 hasPublicationYear "2022" @default.
• W4308304623 type Work @default.
• W4308304623 citedByCount "1" @default.
• W4308304623 countsByYear W43083046232023 @default.
• W4308304623 crossrefType "posted-content" @default.
• W4308304623 hasAuthorship W4308304623A5000728648 @default.
• W4308304623 hasAuthorship W4308304623A5004626333 @default.
• W4308304623 hasAuthorship W4308304623A5010776860 @default.
• W4308304623 hasAuthorship W4308304623A5030334202 @default.
• W4308304623 hasAuthorship W4308304623A5040558103 @default.
• W4308304623 hasAuthorship W4308304623A5055838753 @default.
• W4308304623 hasAuthorship W4308304623A5065113766 @default.
• W4308304623 hasAuthorship W4308304623A5067112955 @default.
• W4308304623 hasAuthorship W4308304623A5075489258 @default.
• W4308304623 hasAuthorship W4308304623A5077955809 @default.
• W4308304623 hasAuthorship W4308304623A5085910420 @default.
• W4308304623 hasBestOaLocation W43083046231 @default.
• W4308304623 hasConcept C111472728 @default.
• W4308304623 hasConcept C138885662 @default.
• W4308304623 hasConcept C160448771 @default.
• W4308304623 hasConcept C185592680 @default.
• W4308304623 hasConcept C202751555 @default.
• W4308304623 hasConcept C203014093 @default.
• W4308304623 hasConcept C207001950 @default.
• W4308304623 hasConcept C2776914184 @default.
• W4308304623 hasConcept C2779244956 @default.
• W4308304623 hasConcept C2779341262 @default.
• W4308304623 hasConcept C2779830541 @default.
• W4308304623 hasConcept C54355233 @default.
• W4308304623 hasConcept C55493867 @default.
• W4308304623 hasConcept C86803240 @default.
• W4308304623 hasConcept C8891405 @default.
• W4308304623 hasConcept C89611455 @default.
• W4308304623 hasConcept C95444343 @default.
• W4308304623 hasConceptScore W4308304623C111472728 @default.
• W4308304623 hasConceptScore W4308304623C138885662 @default.
• W4308304623 hasConceptScore W4308304623C160448771 @default.
• W4308304623 hasConceptScore W4308304623C185592680 @default.
• W4308304623 hasConceptScore W4308304623C202751555 @default.
• W4308304623 hasConceptScore W4308304623C203014093 @default.
• W4308304623 hasConceptScore W4308304623C207001950 @default.
• W4308304623 hasConceptScore W4308304623C2776914184 @default.
• W4308304623 hasConceptScore W4308304623C2779244956 @default.
• W4308304623 hasConceptScore W4308304623C2779341262 @default.
• W4308304623 hasConceptScore W4308304623C2779830541 @default.
• W4308304623 hasConceptScore W4308304623C54355233 @default.
• W4308304623 hasConceptScore W4308304623C55493867 @default.
• W4308304623 hasConceptScore W4308304623C86803240 @default.
• W4308304623 hasConceptScore W4308304623C8891405 @default.
• W4308304623 hasConceptScore W4308304623C89611455 @default.
• W4308304623 hasConceptScore W4308304623C95444343 @default.
• W4308304623 hasLocation W43083046231 @default.
• W4308304623 hasOpenAccess W4308304623 @default.
• W4308304623 hasPrimaryLocation W43083046231 @default.
• W4308304623 hasRelatedWork W1969752809 @default.
• W4308304623 hasRelatedWork W2022088095 @default.

• next