FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308307562> ?p ?o ?g. }

• W4308307562 endingPage "104398" @default.
• W4308307562 startingPage "104398" @default.
• W4308307562 abstract "Background Cognitive impairment is common in patients with multiple sclerosis, even in the early stages of the disease. The Brief International Cognitive Assessment for multiple sclerosis (BICAMS) is a short screening tool developed to assess cognitive function in everyday clinical practice. Objective To investigate associations between volumetric brain measures derived from a magnetic resonance imaging (MRI) examination and performance on BICAMS subtests in early stages of multiple sclerosis (MS). Methods BICAMS was used to assess cognitive function in 49 MS patients at baseline and after one and two years. The patients were separated into two groups (with or without cognitive impairment) based on their performances on BICAMSs subtests. MRI data were analysed by a software tool (MSMetrix), yielding normalized measures of global brain volumes and lesion volumes. Associations between cognitive tests and brain MRI measures were analysed by running correlation analyses, and differences between subgroups and changes over time with independent and paired samples tests, respectively. Results The strongest baseline correlations were found between the BICAMS subtests and normalized whole brain volume (NBV) and grey matter volume (NGV); processing speed r = 0.54/r = 0.48, verbal memory r = 0.49/ r = 0.42, visual memory r = 0.48 /r = 0.39. Only the verbal memory test had significant correlations with T2 and T1 lesion volumes (LV) at both time points; T2LV r = 0.39, T1LV r = 0.38. There were significant loss of grey matter and white matter volume overall (NGV p<0.001, NWV p = 0.003), as well as an increase in T1LV (p = 0.013). The longitudinally defined confirmed cognitively impaired (CCI) and preserved (CCP) patients showed significant group differences on all MRI volume measures at both time points, except for NWV. Only the CCI subgroup showed significant white matter atrophy (p = 0.006) and increase in T2LV (p = 0.029). Conclusions The present study found strong correlations between whole brain and grey matter volumes and performance on the BICAMS subtests as well as significant changes in global volumes from baseline to follow-up with clear differences between patients defined as cognitively impaired and preserved at both baseline and follow-up." @default.
• W4308307562 created "2022-11-10" @default.
• W4308307562 creator A5015324446 @default.
• W4308307562 creator A5052870289 @default.
• W4308307562 creator A5056629578 @default.
• W4308307562 creator A5061891450 @default.
• W4308307562 creator A5063197826 @default.
• W4308307562 creator A5072063407 @default.
• W4308307562 date "2023-01-01" @default.
• W4308307562 modified "2023-10-15" @default.
• W4308307562 title "Brief international cognitive assessment for MS (BICAMS) and global brain volumes in early stages of MS – A longitudinal correlation study" @default.
• W4308307562 cites W1965885704 @default.
• W4308307562 cites W1968103825 @default.
• W4308307562 cites W1981894990 @default.
• W4308307562 cites W1997390910 @default.
• W4308307562 cites W2012934594 @default.
• W4308307562 cites W2020194517 @default.
• W4308307562 cites W2026913491 @default.
• W4308307562 cites W2034607464 @default.
• W4308307562 cites W2037636284 @default.
• W4308307562 cites W2044437929 @default.
• W4308307562 cites W2047226578 @default.
• W4308307562 cites W2053836109 @default.
• W4308307562 cites W2060129459 @default.
• W4308307562 cites W2061217252 @default.
• W4308307562 cites W2073861322 @default.
• W4308307562 cites W2073931714 @default.
• W4308307562 cites W2085315487 @default.
• W4308307562 cites W2095723566 @default.
• W4308307562 cites W2100135031 @default.
• W4308307562 cites W2103648420 @default.
• W4308307562 cites W2108193054 @default.
• W4308307562 cites W2112165124 @default.
• W4308307562 cites W2114110854 @default.
• W4308307562 cites W2130632081 @default.
• W4308307562 cites W2138779588 @default.
• W4308307562 cites W2142890772 @default.
• W4308307562 cites W2146057830 @default.
• W4308307562 cites W2151576334 @default.
• W4308307562 cites W2157401887 @default.
• W4308307562 cites W2157913517 @default.
• W4308307562 cites W2164564993 @default.
• W4308307562 cites W2168376789 @default.
• W4308307562 cites W2179937702 @default.
• W4308307562 cites W2327520147 @default.
• W4308307562 cites W2481180990 @default.
• W4308307562 cites W2508849241 @default.
• W4308307562 cites W2552697966 @default.
• W4308307562 cites W2562579042 @default.
• W4308307562 cites W2586165015 @default.
• W4308307562 cites W2588292672 @default.
• W4308307562 cites W2611982970 @default.
• W4308307562 cites W266124145 @default.
• W4308307562 cites W2732607870 @default.
• W4308307562 cites W2734175776 @default.
• W4308307562 cites W2742226977 @default.
• W4308307562 cites W2771156313 @default.
• W4308307562 cites W2777074421 @default.
• W4308307562 cites W2783047793 @default.
• W4308307562 cites W2786265511 @default.
• W4308307562 cites W2792796097 @default.
• W4308307562 cites W2808292524 @default.
• W4308307562 cites W2907678554 @default.
• W4308307562 cites W2912531879 @default.
• W4308307562 cites W2914355244 @default.
• W4308307562 cites W2974802481 @default.
• W4308307562 cites W3008600501 @default.
• W4308307562 cites W3010414877 @default.
• W4308307562 cites W3020438786 @default.
• W4308307562 cites W3091893722 @default.
• W4308307562 cites W3137737476 @default.
• W4308307562 cites W4211090999 @default.
• W4308307562 cites W808927089 @default.
• W4308307562 doi "https://doi.org/10.1016/j.msard.2022.104398" @default.
• W4308307562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36462469" @default.
• W4308307562 hasPublicationYear "2023" @default.
• W4308307562 type Work @default.
• W4308307562 citedByCount "2" @default.
• W4308307562 countsByYear W43083075622023 @default.
• W4308307562 crossrefType "journal-article" @default.
• W4308307562 hasAuthorship W4308307562A5015324446 @default.
• W4308307562 hasAuthorship W4308307562A5052870289 @default.
• W4308307562 hasAuthorship W4308307562A5056629578 @default.
• W4308307562 hasAuthorship W4308307562A5061891450 @default.
• W4308307562 hasAuthorship W4308307562A5063197826 @default.
• W4308307562 hasAuthorship W4308307562A5072063407 @default.
• W4308307562 hasConcept C105641010 @default.
• W4308307562 hasConcept C117220453 @default.
• W4308307562 hasConcept C118552586 @default.
• W4308307562 hasConcept C126322002 @default.
• W4308307562 hasConcept C126838900 @default.
• W4308307562 hasConcept C142724271 @default.
• W4308307562 hasConcept C143409427 @default.
• W4308307562 hasConcept C169900460 @default.
• W4308307562 hasConcept C185711340 @default.
• W4308307562 hasConcept C2524010 @default.
• W4308307562 hasConcept C2778013878 @default.
• W4308307562 hasConcept C2780640218 @default.

• next