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- W4308308358 abstract "Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neural architecture, which may be a sign of successful adaptation, whereas persistence of these changes when stress ends indicate failed resilience. Neuroendocrine homeostasis and stress response are mainly dependent upon the functioning of the hypothalamic–pituitary–adrenal axis. Neurosteroids will fluctuate depending on whether the stress is acute or chronic. Advancements in neurosteroid research have led to the identification of multiple targets for drug development, but the most promising innovative target may be neurogenesis, given its potential impact in neurodegenerative disorders like Alzheimer's disease. Allopregnanolone is an endogenous pregnane neurosteroid and a reduced metabolite of progesterone, which acts as a potent allosteric modulator and direct activator of the GABA-chloride channel complex. Perhaps the most intriguing finding related to the potential therapeutic effects of allopregnanolone is its potential to promote neuroregeneration." @default.
- W4308308358 created "2022-11-10" @default.
- W4308308358 creator A5003163647 @default.
- W4308308358 creator A5005920250 @default.
- W4308308358 date "2022-11-01" @default.
- W4308308358 modified "2023-10-16" @default.
- W4308308358 title "Allopregnanolone: Regenerative therapeutic to restore neurological health" @default.
- W4308308358 cites W155479038 @default.
- W4308308358 cites W1567085508 @default.
- W4308308358 cites W1567481304 @default.
- W4308308358 cites W1592665312 @default.
- W4308308358 cites W1686749590 @default.
- W4308308358 cites W1760151818 @default.
- W4308308358 cites W1876851010 @default.
- W4308308358 cites W1887384960 @default.
- W4308308358 cites W1916976076 @default.
- W4308308358 cites W1950408822 @default.
- W4308308358 cites W1958676502 @default.
- W4308308358 cites W1968427184 @default.
- W4308308358 cites W1985891090 @default.
- W4308308358 cites W1988405118 @default.
- W4308308358 cites W1992357100 @default.
- W4308308358 cites W2000712333 @default.
- W4308308358 cites W2000787248 @default.
- W4308308358 cites W2016703057 @default.
- W4308308358 cites W2018831144 @default.
- W4308308358 cites W2019528658 @default.
- W4308308358 cites W2023343492 @default.
- W4308308358 cites W2024344189 @default.
- W4308308358 cites W2032468493 @default.
- W4308308358 cites W2035244476 @default.
- W4308308358 cites W2037979274 @default.
- W4308308358 cites W2042141620 @default.
- W4308308358 cites W2045756579 @default.
- W4308308358 cites W2051173215 @default.
- W4308308358 cites W2051585413 @default.
- W4308308358 cites W2052906514 @default.
- W4308308358 cites W2054871562 @default.
- W4308308358 cites W2063132305 @default.
- W4308308358 cites W2064672450 @default.
- W4308308358 cites W2067083885 @default.
- W4308308358 cites W2067856703 @default.
- W4308308358 cites W2068847189 @default.
- W4308308358 cites W2071070948 @default.
- W4308308358 cites W2076845765 @default.
- W4308308358 cites W2077468380 @default.
- W4308308358 cites W2079103153 @default.
- W4308308358 cites W2083552615 @default.
- W4308308358 cites W2084243951 @default.
- W4308308358 cites W2084777187 @default.
- W4308308358 cites W2084983915 @default.
- W4308308358 cites W2085472382 @default.
- W4308308358 cites W2086519799 @default.
- W4308308358 cites W2087243986 @default.
- W4308308358 cites W2090698166 @default.
- W4308308358 cites W2091997230 @default.
- W4308308358 cites W2094798800 @default.
- W4308308358 cites W2095016919 @default.
- W4308308358 cites W2100095860 @default.
- W4308308358 cites W2101301851 @default.
- W4308308358 cites W2105089471 @default.
- W4308308358 cites W2114645992 @default.
- W4308308358 cites W2116769635 @default.
- W4308308358 cites W2127483997 @default.
- W4308308358 cites W2128168682 @default.
- W4308308358 cites W2130186201 @default.
- W4308308358 cites W2132726881 @default.
- W4308308358 cites W2136863044 @default.
- W4308308358 cites W2144101679 @default.
- W4308308358 cites W2145235967 @default.
- W4308308358 cites W2161288077 @default.
- W4308308358 cites W2170226754 @default.
- W4308308358 cites W2171196764 @default.
- W4308308358 cites W2281965232 @default.
- W4308308358 cites W2300528976 @default.
- W4308308358 cites W2460312596 @default.
- W4308308358 cites W2562757915 @default.
- W4308308358 cites W2610621727 @default.
- W4308308358 cites W2756158919 @default.
- W4308308358 cites W2796418566 @default.
- W4308308358 cites W2799823550 @default.
- W4308308358 cites W2811270075 @default.
- W4308308358 cites W2889396010 @default.
- W4308308358 cites W2897539371 @default.
- W4308308358 cites W2898560358 @default.
- W4308308358 cites W2933060089 @default.
- W4308308358 cites W2960278463 @default.
- W4308308358 cites W2974455366 @default.
- W4308308358 cites W3000018611 @default.
- W4308308358 cites W3037278485 @default.
- W4308308358 cites W3091064340 @default.
- W4308308358 cites W3111388787 @default.
- W4308308358 cites W3161507977 @default.
- W4308308358 cites W3174035807 @default.
- W4308308358 cites W4220700431 @default.
- W4308308358 cites W4301495396 @default.
- W4308308358 doi "https://doi.org/10.1016/j.ynstr.2022.100502" @default.
- W4308308358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36532370" @default.