Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308308464> ?p ?o ?g. }
- W4308308464 endingPage "139" @default.
- W4308308464 startingPage "129" @default.
- W4308308464 abstract "Non-alcoholic fatty liver disease (NAFLD) is increasingly affecting human health and the economy worldwide due to various factors. Here, we found that the expression of TGF-β1 and TLR2 was significantly up-regulated in liver samples from both rats and mice nonalcoholic steatohepatitis (NASH) models. By constructing corresponding cell model, we found that TGF-β1 challenge can positively regulate the expression of TLR2 and p-Smad2/3, and the dual luciferase reporter gene system and EMSA assay confirmed the existence of Smad3 binding site (-916 ∼ -906) in the promoter region of TLR2. The overexpression and interference changes of Smad2/3 further verified the above experimental results. Taken together, these findings suggest that TGF-β1 promotes TLR2 transcription and its target gene expression via Smad3, leading to malignant exacerbation of liver inflammation in NASH, which provides new insights into the treatment of NASH." @default.
- W4308308464 created "2022-11-10" @default.
- W4308308464 creator A5007348590 @default.
- W4308308464 creator A5007522630 @default.
- W4308308464 creator A5011245802 @default.
- W4308308464 creator A5012677271 @default.
- W4308308464 creator A5017193282 @default.
- W4308308464 creator A5029741250 @default.
- W4308308464 creator A5039820804 @default.
- W4308308464 creator A5040295173 @default.
- W4308308464 creator A5067651962 @default.
- W4308308464 creator A5074786531 @default.
- W4308308464 creator A5084587584 @default.
- W4308308464 creator A5089733388 @default.
- W4308308464 date "2022-12-01" @default.
- W4308308464 modified "2023-10-01" @default.
- W4308308464 title "TGF-β1 contributes to the hepatic inflammation in animal models with nonalcoholic steatohepatitis by Smad3/TLR2 signaling pathway" @default.
- W4308308464 cites W1524114372 @default.
- W4308308464 cites W1989429848 @default.
- W4308308464 cites W2015192989 @default.
- W4308308464 cites W2060606699 @default.
- W4308308464 cites W2088971991 @default.
- W4308308464 cites W2103139789 @default.
- W4308308464 cites W2204688218 @default.
- W4308308464 cites W2347012456 @default.
- W4308308464 cites W2466225158 @default.
- W4308308464 cites W2484335322 @default.
- W4308308464 cites W2560615789 @default.
- W4308308464 cites W2760815328 @default.
- W4308308464 cites W2806839461 @default.
- W4308308464 cites W2810629608 @default.
- W4308308464 cites W2881438881 @default.
- W4308308464 cites W2917714624 @default.
- W4308308464 cites W2967702639 @default.
- W4308308464 cites W2993083975 @default.
- W4308308464 cites W2993765917 @default.
- W4308308464 cites W2997221406 @default.
- W4308308464 cites W3004340960 @default.
- W4308308464 cites W3004950447 @default.
- W4308308464 cites W3010670730 @default.
- W4308308464 cites W3012775092 @default.
- W4308308464 cites W3015579983 @default.
- W4308308464 cites W3033146331 @default.
- W4308308464 cites W3048209526 @default.
- W4308308464 cites W3075063021 @default.
- W4308308464 cites W3096590336 @default.
- W4308308464 cites W3110719335 @default.
- W4308308464 cites W3111342436 @default.
- W4308308464 cites W3112103684 @default.
- W4308308464 cites W3114521543 @default.
- W4308308464 cites W3115117553 @default.
- W4308308464 cites W3117083078 @default.
- W4308308464 cites W3117275669 @default.
- W4308308464 cites W3117730334 @default.
- W4308308464 cites W3119060929 @default.
- W4308308464 cites W3126379854 @default.
- W4308308464 cites W3135593955 @default.
- W4308308464 cites W4292001606 @default.
- W4308308464 doi "https://doi.org/10.1016/j.molimm.2022.10.014" @default.
- W4308308464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36334346" @default.
- W4308308464 hasPublicationYear "2022" @default.
- W4308308464 type Work @default.
- W4308308464 citedByCount "2" @default.
- W4308308464 countsByYear W43083084642023 @default.
- W4308308464 crossrefType "journal-article" @default.
- W4308308464 hasAuthorship W4308308464A5007348590 @default.
- W4308308464 hasAuthorship W4308308464A5007522630 @default.
- W4308308464 hasAuthorship W4308308464A5011245802 @default.
- W4308308464 hasAuthorship W4308308464A5012677271 @default.
- W4308308464 hasAuthorship W4308308464A5017193282 @default.
- W4308308464 hasAuthorship W4308308464A5029741250 @default.
- W4308308464 hasAuthorship W4308308464A5039820804 @default.
- W4308308464 hasAuthorship W4308308464A5040295173 @default.
- W4308308464 hasAuthorship W4308308464A5067651962 @default.
- W4308308464 hasAuthorship W4308308464A5074786531 @default.
- W4308308464 hasAuthorship W4308308464A5084587584 @default.
- W4308308464 hasAuthorship W4308308464A5089733388 @default.
- W4308308464 hasConcept C126322002 @default.
- W4308308464 hasConcept C185592680 @default.
- W4308308464 hasConcept C2776070231 @default.
- W4308308464 hasConcept C2776914184 @default.
- W4308308464 hasConcept C2776954865 @default.
- W4308308464 hasConcept C2777014857 @default.
- W4308308464 hasConcept C2778772119 @default.
- W4308308464 hasConcept C2779134260 @default.
- W4308308464 hasConcept C2779478299 @default.
- W4308308464 hasConcept C2781236682 @default.
- W4308308464 hasConcept C3018708256 @default.
- W4308308464 hasConcept C502942594 @default.
- W4308308464 hasConcept C62478195 @default.
- W4308308464 hasConcept C71924100 @default.
- W4308308464 hasConcept C86803240 @default.
- W4308308464 hasConcept C95444343 @default.
- W4308308464 hasConceptScore W4308308464C126322002 @default.
- W4308308464 hasConceptScore W4308308464C185592680 @default.
- W4308308464 hasConceptScore W4308308464C2776070231 @default.
- W4308308464 hasConceptScore W4308308464C2776914184 @default.
- W4308308464 hasConceptScore W4308308464C2776954865 @default.