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- W4308310081 abstract "Cytokine storm syndromes, including severe cases of the pandemic coronavirus disease 2019 (COVID-19), are frequently fatal complications of infections, malignancies, and rheumatic conditions.1 The prototypic cytokine storm syndrome is a rare (1 in 50,000 live births) entity of familial hemophagocytic lymphohistiocytosis (HLH) resulting from homozygous defects in genes necessary for perforin-mediated cytolysis by natural killer cells and CD8 T lymphocytes.1 This was modeled by Jordan et al2 in 2004 in perforin-deficient mice infected with the lymphocytic choriomeningitis virus (LCMV)." @default.
- W4308310081 created "2022-11-10" @default.
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- W4308310081 date "2023-01-01" @default.
- W4308310081 modified "2023-10-16" @default.
- W4308310081 title "Double-barrel targeting of IFN-γ to treat hemophagocytic lymphohistiocytosis" @default.
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- W4308310081 doi "https://doi.org/10.1016/j.jaci.2022.10.024" @default.
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