Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308311917> ?p ?o ?g. }
- W4308311917 endingPage "117085" @default.
- W4308311917 startingPage "117085" @default.
- W4308311917 abstract "Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Here, we exploited the synergy between histone deacetylase inhibitors (HDACi) and cyclooxygenase 2 (COX-2) inhibitors by generating and testing a series of hybrid Celecoxib-HDAC inhibitors (selenium-containing analogues of Celecoxib) on ALL cells, of which compound 11 exhibited significant inducement to kill NALM6 cells with an average IC50 of 9.95 ± 0.44 μM compared with control Celecoxib at 28.58 ± 1.44 μM and inhibited NALM6 cells growth via the inhibition of the cell cycle in G2 phase. Furthermore, compound 11 induced apoptosis by activating PARP cleavage. Taken together, compound 11 possessed the potential to be developed further as a chemotherapeutic agent for ALL." @default.
- W4308311917 created "2022-11-10" @default.
- W4308311917 creator A5000447919 @default.
- W4308311917 creator A5005368416 @default.
- W4308311917 creator A5035282947 @default.
- W4308311917 creator A5038776482 @default.
- W4308311917 creator A5040658425 @default.
- W4308311917 creator A5050100968 @default.
- W4308311917 creator A5062532389 @default.
- W4308311917 creator A5066716873 @default.
- W4308311917 creator A5067795175 @default.
- W4308311917 date "2022-12-01" @default.
- W4308311917 modified "2023-10-13" @default.
- W4308311917 title "Novel bioactive hybrid Celecoxib-HDAC Inhibitor, induces apoptosis in human acute lymphoblastic leukemia cells" @default.
- W4308311917 cites W1827802461 @default.
- W4308311917 cites W1971738816 @default.
- W4308311917 cites W1997166178 @default.
- W4308311917 cites W2003171555 @default.
- W4308311917 cites W2016833582 @default.
- W4308311917 cites W2027645788 @default.
- W4308311917 cites W2030895819 @default.
- W4308311917 cites W2034244318 @default.
- W4308311917 cites W2038248421 @default.
- W4308311917 cites W2050074797 @default.
- W4308311917 cites W2056259078 @default.
- W4308311917 cites W2062828530 @default.
- W4308311917 cites W2084991244 @default.
- W4308311917 cites W2086799752 @default.
- W4308311917 cites W2087545262 @default.
- W4308311917 cites W2088905899 @default.
- W4308311917 cites W2099803844 @default.
- W4308311917 cites W2123274778 @default.
- W4308311917 cites W2143378100 @default.
- W4308311917 cites W2151717296 @default.
- W4308311917 cites W2166186271 @default.
- W4308311917 cites W2168820246 @default.
- W4308311917 cites W2216929617 @default.
- W4308311917 cites W2473186299 @default.
- W4308311917 cites W2521591132 @default.
- W4308311917 cites W2534745005 @default.
- W4308311917 cites W2586397019 @default.
- W4308311917 cites W2725970815 @default.
- W4308311917 cites W2793926864 @default.
- W4308311917 cites W2795913023 @default.
- W4308311917 cites W2811649571 @default.
- W4308311917 cites W2883657104 @default.
- W4308311917 cites W2897807203 @default.
- W4308311917 cites W2912582797 @default.
- W4308311917 cites W2938451492 @default.
- W4308311917 cites W2978917647 @default.
- W4308311917 cites W2979606212 @default.
- W4308311917 cites W2999407263 @default.
- W4308311917 cites W3017013979 @default.
- W4308311917 cites W305248552 @default.
- W4308311917 cites W3135637271 @default.
- W4308311917 cites W3174693089 @default.
- W4308311917 cites W3176770947 @default.
- W4308311917 cites W4212860119 @default.
- W4308311917 cites W4220969090 @default.
- W4308311917 doi "https://doi.org/10.1016/j.bmc.2022.117085" @default.
- W4308311917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395680" @default.
- W4308311917 hasPublicationYear "2022" @default.
- W4308311917 type Work @default.
- W4308311917 citedByCount "2" @default.
- W4308311917 countsByYear W43083119172023 @default.
- W4308311917 crossrefType "journal-article" @default.
- W4308311917 hasAuthorship W4308311917A5000447919 @default.
- W4308311917 hasAuthorship W4308311917A5005368416 @default.
- W4308311917 hasAuthorship W4308311917A5035282947 @default.
- W4308311917 hasAuthorship W4308311917A5038776482 @default.
- W4308311917 hasAuthorship W4308311917A5040658425 @default.
- W4308311917 hasAuthorship W4308311917A5050100968 @default.
- W4308311917 hasAuthorship W4308311917A5062532389 @default.
- W4308311917 hasAuthorship W4308311917A5066716873 @default.
- W4308311917 hasAuthorship W4308311917A5067795175 @default.
- W4308311917 hasConcept C104317684 @default.
- W4308311917 hasConcept C181199279 @default.
- W4308311917 hasConcept C185592680 @default.
- W4308311917 hasConcept C190283241 @default.
- W4308311917 hasConcept C203014093 @default.
- W4308311917 hasConcept C2776202225 @default.
- W4308311917 hasConcept C2776467144 @default.
- W4308311917 hasConcept C2778305200 @default.
- W4308311917 hasConcept C2778461978 @default.
- W4308311917 hasConcept C2779689624 @default.
- W4308311917 hasConcept C29537977 @default.
- W4308311917 hasConcept C502942594 @default.
- W4308311917 hasConcept C54355233 @default.
- W4308311917 hasConcept C55493867 @default.
- W4308311917 hasConcept C64927066 @default.
- W4308311917 hasConcept C71924100 @default.
- W4308311917 hasConcept C81885089 @default.
- W4308311917 hasConcept C86803240 @default.
- W4308311917 hasConcept C98274493 @default.
- W4308311917 hasConceptScore W4308311917C104317684 @default.
- W4308311917 hasConceptScore W4308311917C181199279 @default.
- W4308311917 hasConceptScore W4308311917C185592680 @default.
- W4308311917 hasConceptScore W4308311917C190283241 @default.