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- W4308327959 abstract "Glycosylated nanoparticles (NPs) have drawn a lot of attention in the biomedical field over the past few decades, particularly in applications like targeted drug delivery. Mannosylated NPs and mannan-binding lectins/proteins (MBL/MBP) are emerging as promising tools for delivery of drugs, medicines, and enzymes to targeted tissues and cells as nanocarriers, enhancing their therapeutic benefits while avoiding the adverse effects of the drug. The occurrence of plenty of lectin receptors and their mannan ligands on cell surfaces makes them multifaceted carriers appropriate for specific delivery of bioactive drug materials to their targeted sites. Thus, the present review describes the tethering of mannose (Man) to several nanostructures, like micelles, liposomes, and other NPs, applicable for drug delivery systems. Bioadhesion through MBL-like receptors on cells has involvements applicable to additional arenas of science, for example gene delivery, tissue engineering, biomaterials, and nanotechnology. This review also focuses on the role of various aspects of drug/antigen delivery using (i) mannosylated NPs, (ii) mannosylated lectins, (iii) amphiphilic glycopolymer NPs, and (iv) natural mannan-containing polysaccharides, with most significant applications of MBL-based NPs as multivalent scaffolds, using different strategies. Mannosylated NPs and/or MBL/MBP are coming up as viable and versatile tools as nanocarriers to deliver drugs and enzymes precisely to their target tissues or cells. The presence of abundant number of lectin receptors and their mannan ligands on cell surfaces makes them versatile carriers suitable for the targeted delivery of bioactive drugs." @default.
- W4308327959 created "2022-11-11" @default.
- W4308327959 creator A5008960911 @default.
- W4308327959 creator A5054084181 @default.
- W4308327959 date "2022-11-01" @default.
- W4308327959 modified "2023-10-01" @default.
- W4308327959 title "Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine" @default.
- W4308327959 cites W1059641546 @default.
- W4308327959 cites W108441297 @default.
- W4308327959 cites W1480803047 @default.
- W4308327959 cites W1508895967 @default.
- W4308327959 cites W1548443253 @default.
- W4308327959 cites W1596906634 @default.
- W4308327959 cites W1821674784 @default.
- W4308327959 cites W1965530147 @default.
- W4308327959 cites W1966009267 @default.
- W4308327959 cites W1968638592 @default.
- W4308327959 cites W1972369399 @default.
- W4308327959 cites W1973546785 @default.
- W4308327959 cites W1975709358 @default.
- W4308327959 cites W1975826661 @default.
- W4308327959 cites W1976118781 @default.
- W4308327959 cites W1976632269 @default.
- W4308327959 cites W1978271591 @default.
- W4308327959 cites W1979916844 @default.
- W4308327959 cites W1979994342 @default.
- W4308327959 cites W1980310024 @default.
- W4308327959 cites W1981256115 @default.
- W4308327959 cites W1982267003 @default.
- W4308327959 cites W1982342199 @default.
- W4308327959 cites W1984447304 @default.
- W4308327959 cites W1986375897 @default.
- W4308327959 cites W1987303550 @default.
- W4308327959 cites W1987686104 @default.
- W4308327959 cites W1988749800 @default.
- W4308327959 cites W1989961111 @default.
- W4308327959 cites W1990316258 @default.
- W4308327959 cites W1991418834 @default.
- W4308327959 cites W1991731427 @default.
- W4308327959 cites W1992981116 @default.
- W4308327959 cites W1995808140 @default.
- W4308327959 cites W1996806962 @default.
- W4308327959 cites W2000180628 @default.
- W4308327959 cites W2000392212 @default.
- W4308327959 cites W2004138424 @default.
- W4308327959 cites W2006682004 @default.
- W4308327959 cites W2007895902 @default.
- W4308327959 cites W2008029384 @default.
- W4308327959 cites W2008471218 @default.
- W4308327959 cites W2009592823 @default.
- W4308327959 cites W2010753579 @default.
- W4308327959 cites W2011090397 @default.
- W4308327959 cites W2012657759 @default.
- W4308327959 cites W2012823237 @default.
- W4308327959 cites W2013706088 @default.
- W4308327959 cites W2014144492 @default.
- W4308327959 cites W2014732378 @default.
- W4308327959 cites W2015031892 @default.
- W4308327959 cites W2016543061 @default.
- W4308327959 cites W2020018630 @default.
- W4308327959 cites W2020738810 @default.
- W4308327959 cites W2022128030 @default.
- W4308327959 cites W2023268526 @default.
- W4308327959 cites W2025245311 @default.
- W4308327959 cites W2027302030 @default.
- W4308327959 cites W2028501033 @default.
- W4308327959 cites W2028804451 @default.
- W4308327959 cites W2030426939 @default.
- W4308327959 cites W2030855909 @default.
- W4308327959 cites W2031887559 @default.
- W4308327959 cites W2033852473 @default.
- W4308327959 cites W2034243683 @default.
- W4308327959 cites W2035059820 @default.
- W4308327959 cites W2038015652 @default.
- W4308327959 cites W2045647683 @default.
- W4308327959 cites W2052745039 @default.
- W4308327959 cites W2058735358 @default.
- W4308327959 cites W2063160396 @default.
- W4308327959 cites W2063494450 @default.
- W4308327959 cites W2066750463 @default.
- W4308327959 cites W2067759081 @default.
- W4308327959 cites W2072415268 @default.
- W4308327959 cites W2073219580 @default.
- W4308327959 cites W2073865821 @default.
- W4308327959 cites W2073919151 @default.
- W4308327959 cites W2074772243 @default.
- W4308327959 cites W2077128382 @default.
- W4308327959 cites W2079594934 @default.
- W4308327959 cites W2081570846 @default.
- W4308327959 cites W2084308282 @default.
- W4308327959 cites W2085432354 @default.
- W4308327959 cites W2086626884 @default.
- W4308327959 cites W2086719948 @default.
- W4308327959 cites W2087181772 @default.
- W4308327959 cites W2088860476 @default.
- W4308327959 cites W2089699539 @default.
- W4308327959 cites W2091788520 @default.
- W4308327959 cites W2093717599 @default.
- W4308327959 cites W2094157563 @default.
- W4308327959 cites W2095502435 @default.