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- W4308331256 abstract "Structural and Doppler velocity data collected from optical coherence tomography have already provided crucial insights into cardiac morphogenesis. X-ray microtomography and other ex vivo methods have elucidated structural details of developing hearts. However, by itself, no single imaging modality can provide comprehensive information allowing to fully decipher the inner workings of an entire developing organ. Hence, we introduce a specimen-specific correlative multimodal imaging workflow combining OCT and micro-CT imaging which is applicable for modeling of early chick heart development—a valuable model organism in cardiovascular development research. The image acquisition and processing employ common reagents, lab-based micro-CT imaging, and software that is free for academic use. Our goal is to provide a step-by-step guide on how to implement this workflow and to demonstrate why those two modalities together have the potential to provide new insight into normal cardiac development and heart malformations leading to congenital heart disease." @default.
- W4308331256 created "2022-11-11" @default.
- W4308331256 creator A5060401853 @default.
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- W4308331256 date "2022-11-03" @default.
- W4308331256 modified "2023-10-14" @default.
- W4308331256 title "OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling" @default.
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- W4308331256 doi "https://doi.org/10.3390/jcdd9110379" @default.
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- W4308331256 hasPublicationYear "2022" @default.
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