Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308331630> ?p ?o ?g. }
- W4308331630 endingPage "694" @default.
- W4308331630 startingPage "694" @default.
- W4308331630 abstract "A potential fucoidan-based PEGylated PLGA nanoparticles (NPs) offering a proper delivery of N-methyl anthranilic acid (MA, a model of hydrophobic anti-inflammatory drug) have been developed via the formation of fucoidan aqueous coating surrounding PEGylated PLGA NPs. The optimum formulation (FuP2) composed of fucoidan:m-PEG-PLGA (1:0.5 w/w) with particle size (365 ± 20.76 nm), zeta potential (-22.30 ± 2.56 mV), % entrapment efficiency (85.45 ± 7.41), drug loading (51.36 ± 4.75 µg/mg of NPs), % initial burst (47.91 ± 5.89), and % cumulative release (102.79 ± 6.89) has been further investigated for the anti-inflammatory in vivo study. This effect of FuP2 was assessed in rats' carrageenan-induced acute inflammation model. The average weight of the paw edema was significantly lowered (p ≤ 0.05) by treatment with FuP2. Moreover, cyclooxygenase-2 and tumor necrosis factor-alpha immunostaining were decreased in FuP2 treated group compared to the other groups. The levels of prostaglandin E2, nitric oxide, and malondialdehyde were significantly reduced (p ≤ 0.05) in the FuP2-treated group. A significant reduction (p ≤ 0.05) in the expression of interleukins (IL-1β and IL-6) with an improvement of the histological findings of the paw tissues was observed in the FuP2-treated group. Thus, fucoidan-based PEGylated PLGA-MA NPs are a promising anti-inflammatory delivery system that can be applied for other similar drugs potentiating their pharmacological and pharmacokinetic properties." @default.
- W4308331630 created "2022-11-11" @default.
- W4308331630 creator A5022322953 @default.
- W4308331630 creator A5037358144 @default.
- W4308331630 creator A5041005845 @default.
- W4308331630 creator A5054866724 @default.
- W4308331630 creator A5066349138 @default.
- W4308331630 creator A5066967924 @default.
- W4308331630 creator A5079064455 @default.
- W4308331630 date "2022-11-04" @default.
- W4308331630 modified "2023-10-05" @default.
- W4308331630 title "Insight into Fucoidan-Based PEGylated PLGA Nanoparticles Encapsulating Methyl Anthranilic Acid: In Vitro Evaluation and In Vivo Anti-Inflammatory Study" @default.
- W4308331630 cites W1488960455 @default.
- W4308331630 cites W1592535071 @default.
- W4308331630 cites W1973233531 @default.
- W4308331630 cites W2028629464 @default.
- W4308331630 cites W2049236860 @default.
- W4308331630 cites W2075651130 @default.
- W4308331630 cites W2090510390 @default.
- W4308331630 cites W2111370861 @default.
- W4308331630 cites W2112295809 @default.
- W4308331630 cites W2141737447 @default.
- W4308331630 cites W2340630159 @default.
- W4308331630 cites W2399608643 @default.
- W4308331630 cites W2468689986 @default.
- W4308331630 cites W2554614442 @default.
- W4308331630 cites W2764241735 @default.
- W4308331630 cites W2766571577 @default.
- W4308331630 cites W2767027881 @default.
- W4308331630 cites W2771472591 @default.
- W4308331630 cites W2780416230 @default.
- W4308331630 cites W2790056846 @default.
- W4308331630 cites W2801901575 @default.
- W4308331630 cites W2908498115 @default.
- W4308331630 cites W2910377276 @default.
- W4308331630 cites W2924560003 @default.
- W4308331630 cites W2946351703 @default.
- W4308331630 cites W2948410175 @default.
- W4308331630 cites W2953103942 @default.
- W4308331630 cites W2964822268 @default.
- W4308331630 cites W2971390047 @default.
- W4308331630 cites W3004458192 @default.
- W4308331630 cites W3011234646 @default.
- W4308331630 cites W3037413757 @default.
- W4308331630 cites W3037493880 @default.
- W4308331630 cites W3041720930 @default.
- W4308331630 cites W3093261693 @default.
- W4308331630 cites W3104974074 @default.
- W4308331630 cites W3132167811 @default.
- W4308331630 cites W3199500726 @default.
- W4308331630 cites W3206665336 @default.
- W4308331630 cites W4200221550 @default.
- W4308331630 cites W4200430220 @default.
- W4308331630 cites W4205453277 @default.
- W4308331630 cites W4210421680 @default.
- W4308331630 cites W4213287913 @default.
- W4308331630 cites W4226371009 @default.
- W4308331630 cites W4280502637 @default.
- W4308331630 cites W4281479305 @default.
- W4308331630 cites W4283009030 @default.
- W4308331630 cites W4293769846 @default.
- W4308331630 doi "https://doi.org/10.3390/md20110694" @default.
- W4308331630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36355017" @default.
- W4308331630 hasPublicationYear "2022" @default.
- W4308331630 type Work @default.
- W4308331630 citedByCount "6" @default.
- W4308331630 countsByYear W43083316302023 @default.
- W4308331630 crossrefType "journal-article" @default.
- W4308331630 hasAuthorship W4308331630A5022322953 @default.
- W4308331630 hasAuthorship W4308331630A5037358144 @default.
- W4308331630 hasAuthorship W4308331630A5041005845 @default.
- W4308331630 hasAuthorship W4308331630A5054866724 @default.
- W4308331630 hasAuthorship W4308331630A5066349138 @default.
- W4308331630 hasAuthorship W4308331630A5066967924 @default.
- W4308331630 hasAuthorship W4308331630A5079064455 @default.
- W4308331630 hasBestOaLocation W43083316301 @default.
- W4308331630 hasConcept C100817775 @default.
- W4308331630 hasConcept C150903083 @default.
- W4308331630 hasConcept C185592680 @default.
- W4308331630 hasConcept C202751555 @default.
- W4308331630 hasConcept C207001950 @default.
- W4308331630 hasConcept C2775909754 @default.
- W4308331630 hasConcept C2780165375 @default.
- W4308331630 hasConcept C55493867 @default.
- W4308331630 hasConcept C71924100 @default.
- W4308331630 hasConcept C86803240 @default.
- W4308331630 hasConcept C98274493 @default.
- W4308331630 hasConceptScore W4308331630C100817775 @default.
- W4308331630 hasConceptScore W4308331630C150903083 @default.
- W4308331630 hasConceptScore W4308331630C185592680 @default.
- W4308331630 hasConceptScore W4308331630C202751555 @default.
- W4308331630 hasConceptScore W4308331630C207001950 @default.
- W4308331630 hasConceptScore W4308331630C2775909754 @default.
- W4308331630 hasConceptScore W4308331630C2780165375 @default.
- W4308331630 hasConceptScore W4308331630C55493867 @default.
- W4308331630 hasConceptScore W4308331630C71924100 @default.
- W4308331630 hasConceptScore W4308331630C86803240 @default.
- W4308331630 hasConceptScore W4308331630C98274493 @default.