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- W4308332435 abstract "Knowledge of the complexity of the gut microbiota is expanding, and its importance in physiological processes and disease development is widely studied. The aim of this review is to present the most relevant and recent research on the associations between gut microbiota and oncologic disease. Recently, a number of associations between the gut microbiome and neoplasms—regarding tumorigenesis, prognosis and therapeutic efficacy—have been reported. The effects of the gut microbiome on these processes are via the direct and indirect immunomodulating effects of bacteria. Studies have been done mainly in adult populations, where its effect on immunomodulating therapies was unambiguous. In paediatric populations, however, due to the low number of cases and the complex therapeutic approaches, there have been only a few studies. Among them, children with acute lymphoblastic leukaemia were mainly involved. Significant alterations in the abundance of certain bacteria were associated with altered therapeutic responses. Regarding solid tumours, studies with low case numbers have been reported; no significant discoveries have been described so far. In the future, studies with larger cohorts are needed in order to better understand the associations between bacteria and neoplasms and to improve prognosis in the paediatric oncologic population." @default.
- W4308332435 created "2022-11-11" @default.
- W4308332435 creator A5020423239 @default.
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- W4308332435 creator A5051401634 @default.
- W4308332435 creator A5053751103 @default.
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- W4308332435 date "2022-11-01" @default.
- W4308332435 modified "2023-10-04" @default.
- W4308332435 title "The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment" @default.
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