Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308334198> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4308334198 endingPage "035" @default.
- W4308334198 startingPage "013" @default.
- W4308334198 abstract "In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease‒modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Depending on product type and development stage, investigators initially enrol volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research centre or multiple centres, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results. Costs for clinical trials can range into the billions of dollars per approved drug. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory. Only 10 percent of all drugs started in human clinical trials become approved drugs." @default.
- W4308334198 created "2022-11-11" @default.
- W4308334198 creator A5005679928 @default.
- W4308334198 creator A5029444707 @default.
- W4308334198 creator A5046885425 @default.
- W4308334198 creator A5049188909 @default.
- W4308334198 creator A5066635917 @default.
- W4308334198 creator A5081546738 @default.
- W4308334198 creator A5087137145 @default.
- W4308334198 date "2022-11-30" @default.
- W4308334198 modified "2023-10-01" @default.
- W4308334198 title "Drug discovery & clinical trials: Login passwords to new life" @default.
- W4308334198 doi "https://doi.org/10.30574/ijsra.2022.7.2.0224" @default.
- W4308334198 hasPublicationYear "2022" @default.
- W4308334198 type Work @default.
- W4308334198 citedByCount "0" @default.
- W4308334198 crossrefType "journal-article" @default.
- W4308334198 hasAuthorship W4308334198A5005679928 @default.
- W4308334198 hasAuthorship W4308334198A5029444707 @default.
- W4308334198 hasAuthorship W4308334198A5046885425 @default.
- W4308334198 hasAuthorship W4308334198A5049188909 @default.
- W4308334198 hasAuthorship W4308334198A5066635917 @default.
- W4308334198 hasAuthorship W4308334198A5081546738 @default.
- W4308334198 hasAuthorship W4308334198A5087137145 @default.
- W4308334198 hasBestOaLocation W43083341981 @default.
- W4308334198 hasConcept C144133560 @default.
- W4308334198 hasConcept C150903083 @default.
- W4308334198 hasConcept C2777494893 @default.
- W4308334198 hasConcept C2780035454 @default.
- W4308334198 hasConcept C535046627 @default.
- W4308334198 hasConcept C60644358 @default.
- W4308334198 hasConcept C63433958 @default.
- W4308334198 hasConcept C64903051 @default.
- W4308334198 hasConcept C70721500 @default.
- W4308334198 hasConcept C71924100 @default.
- W4308334198 hasConcept C74187038 @default.
- W4308334198 hasConcept C86803240 @default.
- W4308334198 hasConcept C98274493 @default.
- W4308334198 hasConceptScore W4308334198C144133560 @default.
- W4308334198 hasConceptScore W4308334198C150903083 @default.
- W4308334198 hasConceptScore W4308334198C2777494893 @default.
- W4308334198 hasConceptScore W4308334198C2780035454 @default.
- W4308334198 hasConceptScore W4308334198C535046627 @default.
- W4308334198 hasConceptScore W4308334198C60644358 @default.
- W4308334198 hasConceptScore W4308334198C63433958 @default.
- W4308334198 hasConceptScore W4308334198C64903051 @default.
- W4308334198 hasConceptScore W4308334198C70721500 @default.
- W4308334198 hasConceptScore W4308334198C71924100 @default.
- W4308334198 hasConceptScore W4308334198C74187038 @default.
- W4308334198 hasConceptScore W4308334198C86803240 @default.
- W4308334198 hasConceptScore W4308334198C98274493 @default.
- W4308334198 hasIssue "2" @default.
- W4308334198 hasLocation W43083341981 @default.
- W4308334198 hasOpenAccess W4308334198 @default.
- W4308334198 hasPrimaryLocation W43083341981 @default.
- W4308334198 hasRelatedWork W1603416295 @default.
- W4308334198 hasRelatedWork W1983248350 @default.
- W4308334198 hasRelatedWork W2001337146 @default.
- W4308334198 hasRelatedWork W2080081537 @default.
- W4308334198 hasRelatedWork W2329258414 @default.
- W4308334198 hasRelatedWork W2348919896 @default.
- W4308334198 hasRelatedWork W2561827752 @default.
- W4308334198 hasRelatedWork W3044296243 @default.
- W4308334198 hasRelatedWork W3134564766 @default.
- W4308334198 hasRelatedWork W4285506882 @default.
- W4308334198 hasVolume "7" @default.
- W4308334198 isParatext "false" @default.
- W4308334198 isRetracted "false" @default.
- W4308334198 workType "article" @default.