FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308334534> ?p ?o ?g. }

• W4308334534 abstract "Objective To evaluate the efficacy and safety of roxadustat in the treatment of anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients. Materials and methods For this systematic review and meta-analysis, we searched for randomized controlled trials (RCTs) of anemia in NDD-CKD patients to assess the efficacy and safety of roxadustat. The primary efficacy endpoint was the proportion of patients who achieved a hemoglobin (Hb) response. Secondary efficacy endpoints were hepcidin, serum iron, serum ferritin (SF), total iron-binding capacity (TIBC), transferrin saturation (TAST), and low-density lipoprotein (LDL). In addition, adverse events (AEs) were compared. Meta-analyses were performed using Revman 5.4 software. The quality of the evidence was assessed using the Cochrane risk of bias tool. This study was conducted under a pre-established protocol registered with PROSPERO (registration number: CRD42021252331). Results Seven studies enrolled 4,764 patients, of whom 2,730 received roxadustat and 2,034 received placebo. The results of this meta-analysis showed that roxadustat increased Hb levels [weighted mean difference (WMD) = 1.43, 95% CI: 1.17 to 1.68, P &lt; 0.001, I 2 = 95%], and Hb response [relative ratio (RR) = 8.12, 95% CI: 5.80 to 11.37, P &lt; 0.001, I 2 = 61%]. In addition, roxadustat significantly increased transferrin TAST. During the treatment period in patients with anemia, the AEs of roxadustat compared with placebo was not statistically significant. Conclusion Roxadustat can improve anemia in NDD-CKD patients by increasing Hb levels and regulating iron metabolism, but does not increase the incidence of AEs. Systematic review registration [ https://www.crd.york.ac.uk/prospero/ ], identifier [CRD42021252331]." @default.
• W4308334534 created "2022-11-11" @default.
• W4308334534 creator A5011615174 @default.
• W4308334534 creator A5034253192 @default.
• W4308334534 creator A5043522375 @default.
• W4308334534 creator A5045117407 @default.
• W4308334534 creator A5068437649 @default.
• W4308334534 creator A5072435013 @default.
• W4308334534 creator A5077716269 @default.
• W4308334534 date "2022-11-04" @default.
• W4308334534 modified "2023-10-17" @default.
• W4308334534 title "Efficacy and safety of roxadustat for the treatment of anemia in non-dialysis chronic kidney disease patients: A systematic review and meta-analysis of randomized double-blind controlled clinical trials" @default.
• W4308334534 cites W1979742080 @default.
• W4308334534 cites W2003575797 @default.
• W4308334534 cites W2021934308 @default.
• W4308334534 cites W2033803279 @default.
• W4308334534 cites W2040029744 @default.
• W4308334534 cites W2041492515 @default.
• W4308334534 cites W2049855137 @default.
• W4308334534 cites W2051789863 @default.
• W4308334534 cites W2083268019 @default.
• W4308334534 cites W2105003544 @default.
• W4308334534 cites W2124116160 @default.
• W4308334534 cites W2128821627 @default.
• W4308334534 cites W2155760431 @default.
• W4308334534 cites W2167794926 @default.
• W4308334534 cites W2338896111 @default.
• W4308334534 cites W2584260978 @default.
• W4308334534 cites W2599499085 @default.
• W4308334534 cites W2772547249 @default.
• W4308334534 cites W2890093418 @default.
• W4308334534 cites W2890296042 @default.
• W4308334534 cites W2921869424 @default.
• W4308334534 cites W2929594700 @default.
• W4308334534 cites W2963534431 @default.
• W4308334534 cites W2964822808 @default.
• W4308334534 cites W2971004252 @default.
• W4308334534 cites W2971344488 @default.
• W4308334534 cites W2979769504 @default.
• W4308334534 cites W2992680664 @default.
• W4308334534 cites W2994812022 @default.
• W4308334534 cites W2999888185 @default.
• W4308334534 cites W3014325832 @default.
• W4308334534 cites W3015156702 @default.
• W4308334534 cites W3108166106 @default.
• W4308334534 cites W3112489277 @default.
• W4308334534 cites W3128080784 @default.
• W4308334534 cites W3130258858 @default.
• W4308334534 cites W3130928076 @default.
• W4308334534 cites W3144773245 @default.
• W4308334534 cites W3154862417 @default.
• W4308334534 cites W3158203678 @default.
• W4308334534 cites W3162927584 @default.
• W4308334534 cites W3194340159 @default.
• W4308334534 cites W3205384748 @default.
• W4308334534 cites W3211047501 @default.
• W4308334534 cites W41145030 @default.
• W4308334534 cites W4205692196 @default.
• W4308334534 doi "https://doi.org/10.3389/fnut.2022.1029432" @default.
• W4308334534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36466382" @default.
• W4308334534 hasPublicationYear "2022" @default.
• W4308334534 type Work @default.
• W4308334534 citedByCount "3" @default.
• W4308334534 countsByYear W43083345342023 @default.
• W4308334534 crossrefType "journal-article" @default.
• W4308334534 hasAuthorship W4308334534A5011615174 @default.
• W4308334534 hasAuthorship W4308334534A5034253192 @default.
• W4308334534 hasAuthorship W4308334534A5043522375 @default.
• W4308334534 hasAuthorship W4308334534A5045117407 @default.
• W4308334534 hasAuthorship W4308334534A5068437649 @default.
• W4308334534 hasAuthorship W4308334534A5072435013 @default.
• W4308334534 hasAuthorship W4308334534A5077716269 @default.
• W4308334534 hasBestOaLocation W43083345341 @default.
• W4308334534 hasConcept C126322002 @default.
• W4308334534 hasConcept C142724271 @default.
• W4308334534 hasConcept C153852466 @default.
• W4308334534 hasConcept C168563851 @default.
• W4308334534 hasConcept C197934379 @default.
• W4308334534 hasConcept C203092338 @default.
• W4308334534 hasConcept C204787440 @default.
• W4308334534 hasConcept C27081682 @default.
• W4308334534 hasConcept C2777417653 @default.
• W4308334534 hasConcept C2778248108 @default.
• W4308334534 hasConcept C2778653478 @default.
• W4308334534 hasConcept C2779978075 @default.
• W4308334534 hasConcept C71924100 @default.
• W4308334534 hasConcept C90924648 @default.
• W4308334534 hasConcept C95190672 @default.
• W4308334534 hasConceptScore W4308334534C126322002 @default.
• W4308334534 hasConceptScore W4308334534C142724271 @default.
• W4308334534 hasConceptScore W4308334534C153852466 @default.
• W4308334534 hasConceptScore W4308334534C168563851 @default.
• W4308334534 hasConceptScore W4308334534C197934379 @default.
• W4308334534 hasConceptScore W4308334534C203092338 @default.
• W4308334534 hasConceptScore W4308334534C204787440 @default.
• W4308334534 hasConceptScore W4308334534C27081682 @default.
• W4308334534 hasConceptScore W4308334534C2777417653 @default.
• W4308334534 hasConceptScore W4308334534C2778248108 @default.
• W4308334534 hasConceptScore W4308334534C2778653478 @default.
• W4308334534 hasConceptScore W4308334534C2779978075 @default.

• next