FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308336319> ?p ?o ?g. }

• W4308336319 endingPage "961" @default.
• W4308336319 startingPage "961" @default.
• W4308336319 abstract "We have successfully designed a uranyl ion (U(VI)-specific peptide and used it in the fabrication of an electrochemical sensor. The 12-amino acid peptide sequence, (n) DKDGDGYIpTAAE (c), originates from calmodulin, a Ca(II)-binding protein, and contains a phosphothreonine that enhances the sequence’s affinity for U(VI) over Ca(II). The sensing mechanism of this U(VI) sensor is similar to other electrochemical peptide-based sensors, which relies on the change in the flexibility of the peptide probe upon interacting with the target. The sensor was systematically characterized using alternating current voltammetry (ACV) and cyclic voltammetry. Its limit of detection was 50 nM, which is lower than the United States Environmental Protection Agency maximum contaminant level for uranium. The signal saturation time was ~40 min. In addition, it showed minimal cross-reactivity when tested against nine different metal ions, including Ca(II), Mg(II), Pb(II), Hg(II), Cu(II), Fe(II), Zn(II), Cd(II), and Cr(VI). Its reusability and ability to function in diluted aquifer and drinking water samples were further confirmed and validated. The response of the sensor fabricated with the same peptide sequence but with a nonphosphorylated threonine was also analyzed, substantiating the positive effects of threonine phosphorylation on U(VI) binding. This study places emphasis on strategic utilization of non-standard amino acids in the design of metal ion-chelating peptides, which will further diversify the types of peptide recognition elements available for metal ion sensing applications." @default.
• W4308336319 created "2022-11-11" @default.
• W4308336319 creator A5018051109 @default.
• W4308336319 creator A5078017654 @default.
• W4308336319 date "2022-11-02" @default.
• W4308336319 modified "2023-09-30" @default.
• W4308336319 title "Threonine Phosphorylation of an Electrochemical Peptide-Based Sensor to Achieve Improved Uranyl Ion Binding Affinity" @default.
• W4308336319 cites W1967186885 @default.
• W4308336319 cites W1972741315 @default.
• W4308336319 cites W1985619357 @default.
• W4308336319 cites W1985928331 @default.
• W4308336319 cites W1990402608 @default.
• W4308336319 cites W1994284144 @default.
• W4308336319 cites W2008523940 @default.
• W4308336319 cites W2021659755 @default.
• W4308336319 cites W2030490793 @default.
• W4308336319 cites W2036718283 @default.
• W4308336319 cites W2040695109 @default.
• W4308336319 cites W2044959599 @default.
• W4308336319 cites W2046334142 @default.
• W4308336319 cites W2055672686 @default.
• W4308336319 cites W2068082564 @default.
• W4308336319 cites W2068601821 @default.
• W4308336319 cites W2088812863 @default.
• W4308336319 cites W2094550842 @default.
• W4308336319 cites W2117309144 @default.
• W4308336319 cites W2135411874 @default.
• W4308336319 cites W2137020518 @default.
• W4308336319 cites W2140941688 @default.
• W4308336319 cites W2141803207 @default.
• W4308336319 cites W2149661547 @default.
• W4308336319 cites W2165470907 @default.
• W4308336319 cites W2212389104 @default.
• W4308336319 cites W2253670422 @default.
• W4308336319 cites W2271020365 @default.
• W4308336319 cites W2280179718 @default.
• W4308336319 cites W2284222372 @default.
• W4308336319 cites W2294806921 @default.
• W4308336319 cites W2330592293 @default.
• W4308336319 cites W2330768915 @default.
• W4308336319 cites W2553790021 @default.
• W4308336319 cites W2610854547 @default.
• W4308336319 cites W2754451589 @default.
• W4308336319 cites W2804043707 @default.
• W4308336319 cites W2902514069 @default.
• W4308336319 cites W2929686803 @default.
• W4308336319 cites W2979583575 @default.
• W4308336319 cites W2995957401 @default.
• W4308336319 cites W2996295400 @default.
• W4308336319 cites W3018748394 @default.
• W4308336319 cites W3093599521 @default.
• W4308336319 cites W3098886438 @default.
• W4308336319 cites W3173715231 @default.
• W4308336319 cites W3184418279 @default.
• W4308336319 cites W3195396381 @default.
• W4308336319 cites W3203659083 @default.
• W4308336319 cites W4206503170 @default.
• W4308336319 cites W4225082836 @default.
• W4308336319 cites W4285020564 @default.
• W4308336319 doi "https://doi.org/10.3390/bios12110961" @default.
• W4308336319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354470" @default.
• W4308336319 hasPublicationYear "2022" @default.
• W4308336319 type Work @default.
• W4308336319 citedByCount "3" @default.
• W4308336319 countsByYear W43083363192022 @default.
• W4308336319 countsByYear W43083363192023 @default.
• W4308336319 crossrefType "journal-article" @default.
• W4308336319 hasAuthorship W4308336319A5018051109 @default.
• W4308336319 hasAuthorship W4308336319A5078017654 @default.
• W4308336319 hasBestOaLocation W43083363191 @default.
• W4308336319 hasConcept C11960822 @default.
• W4308336319 hasConcept C145148216 @default.
• W4308336319 hasConcept C147789679 @default.
• W4308336319 hasConcept C17525397 @default.
• W4308336319 hasConcept C178790620 @default.
• W4308336319 hasConcept C179104552 @default.
• W4308336319 hasConcept C185592680 @default.
• W4308336319 hasConcept C199164860 @default.
• W4308336319 hasConcept C21951064 @default.
• W4308336319 hasConcept C2775880066 @default.
• W4308336319 hasConcept C2776414213 @default.
• W4308336319 hasConcept C2777869211 @default.
• W4308336319 hasConcept C2778468930 @default.
• W4308336319 hasConcept C2779281246 @default.
• W4308336319 hasConcept C52859227 @default.
• W4308336319 hasConcept C544153396 @default.
• W4308336319 hasConcept C55493867 @default.
• W4308336319 hasConceptScore W4308336319C11960822 @default.
• W4308336319 hasConceptScore W4308336319C145148216 @default.
• W4308336319 hasConceptScore W4308336319C147789679 @default.
• W4308336319 hasConceptScore W4308336319C17525397 @default.
• W4308336319 hasConceptScore W4308336319C178790620 @default.
• W4308336319 hasConceptScore W4308336319C179104552 @default.
• W4308336319 hasConceptScore W4308336319C185592680 @default.
• W4308336319 hasConceptScore W4308336319C199164860 @default.
• W4308336319 hasConceptScore W4308336319C21951064 @default.
• W4308336319 hasConceptScore W4308336319C2775880066 @default.
• W4308336319 hasConceptScore W4308336319C2776414213 @default.

• next