Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308342303> ?p ?o ?g. }
- W4308342303 endingPage "239" @default.
- W4308342303 startingPage "228" @default.
- W4308342303 abstract "Genistein (GEN), a natural isoflavone possesses a wide range of pharmacological properties and nutraceutical applications. GEN has been studied for its anticancer activity against different types of cancers, but its use in clinical practice is limited due to its low water solubility, rapid metabolism and excretion, lack of cancer cell targeting and poor bioavailability. In the present study, we investigated folate receptor-targeted and PEGylated poly(lactide-co-glycolide) nanoparticles (PLGA-PEG-FA NPs) containing GEN for targeted delivery to ovarian cancer cells. PLGA-PEG and PLGA-PEG-FA polymer conjugates were synthesized and characterized. Nano-precipitation method was employed for the fabrication of NPs of PLGA, PLGA-PEG and PLGA-PEG-FA containing GEN. GEN containing PLGA-PEG and PLGA-PEG-FA NPs prepared were small (104.17 ± 1.61 and 125.41 ± 3.11 nm, respectively) and exhibited sustained release of GEN for around six days. Folate-decorated PLGA-PEG NPs showed increased cellular uptake in comparison to non-targeted PLGA-PEG NPs. The GEN containing PLGA-PEG-FA NPs showed superior anticancer activity than non-targeted PLGA and PLGA-PEG NPs in folate receptor-overexpressing ovarian cancer cell line, SKOV-3. The IC50 of GEN, GEN encapsulated NPs of PLGA, PLGA-PEG and PLGA-PEG-FA were 51.48, 26.70, 23.43 and 11.98 µg/ml, respectively. Folate-targeted PLGA nanoparticles could be developed for potential target-specific delivery of GEN in the treatment of ovarian cancer." @default.
- W4308342303 created "2022-11-11" @default.
- W4308342303 creator A5039965685 @default.
- W4308342303 creator A5047547177 @default.
- W4308342303 creator A5050368436 @default.
- W4308342303 creator A5054971303 @default.
- W4308342303 creator A5057091601 @default.
- W4308342303 date "2022-11-03" @default.
- W4308342303 modified "2023-09-30" @default.
- W4308342303 title "Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer" @default.
- W4308342303 cites W1963776452 @default.
- W4308342303 cites W1972520576 @default.
- W4308342303 cites W1982532298 @default.
- W4308342303 cites W1986568717 @default.
- W4308342303 cites W1997635372 @default.
- W4308342303 cites W2000181806 @default.
- W4308342303 cites W2003474213 @default.
- W4308342303 cites W2015639818 @default.
- W4308342303 cites W2019154265 @default.
- W4308342303 cites W2019555018 @default.
- W4308342303 cites W2024507126 @default.
- W4308342303 cites W2024856950 @default.
- W4308342303 cites W2035558311 @default.
- W4308342303 cites W2039078500 @default.
- W4308342303 cites W2040809846 @default.
- W4308342303 cites W2040998006 @default.
- W4308342303 cites W2041284252 @default.
- W4308342303 cites W2046011399 @default.
- W4308342303 cites W2052888695 @default.
- W4308342303 cites W2055483349 @default.
- W4308342303 cites W2060108320 @default.
- W4308342303 cites W2062476487 @default.
- W4308342303 cites W2062796491 @default.
- W4308342303 cites W2084530735 @default.
- W4308342303 cites W2103964549 @default.
- W4308342303 cites W2105812125 @default.
- W4308342303 cites W2110100742 @default.
- W4308342303 cites W2126512953 @default.
- W4308342303 cites W2132318505 @default.
- W4308342303 cites W2132341416 @default.
- W4308342303 cites W2161498908 @default.
- W4308342303 cites W2297085520 @default.
- W4308342303 cites W2317622985 @default.
- W4308342303 cites W2548892576 @default.
- W4308342303 cites W2580664468 @default.
- W4308342303 cites W26051613 @default.
- W4308342303 cites W2745539538 @default.
- W4308342303 cites W2751159760 @default.
- W4308342303 cites W2752430299 @default.
- W4308342303 cites W2799745162 @default.
- W4308342303 cites W2937047141 @default.
- W4308342303 cites W2966871100 @default.
- W4308342303 cites W2977373284 @default.
- W4308342303 cites W3007376025 @default.
- W4308342303 cites W3010165552 @default.
- W4308342303 cites W3011814292 @default.
- W4308342303 cites W3095974822 @default.
- W4308342303 cites W3112640065 @default.
- W4308342303 cites W3135842759 @default.
- W4308342303 cites W36292240 @default.
- W4308342303 doi "https://doi.org/10.1080/21691401.2022.2118758" @default.
- W4308342303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330543" @default.
- W4308342303 hasPublicationYear "2022" @default.
- W4308342303 type Work @default.
- W4308342303 citedByCount "5" @default.
- W4308342303 countsByYear W43083423032023 @default.
- W4308342303 crossrefType "journal-article" @default.
- W4308342303 hasAuthorship W4308342303A5039965685 @default.
- W4308342303 hasAuthorship W4308342303A5047547177 @default.
- W4308342303 hasAuthorship W4308342303A5050368436 @default.
- W4308342303 hasAuthorship W4308342303A5054971303 @default.
- W4308342303 hasAuthorship W4308342303A5057091601 @default.
- W4308342303 hasBestOaLocation W43083423031 @default.
- W4308342303 hasConcept C10138342 @default.
- W4308342303 hasConcept C121608353 @default.
- W4308342303 hasConcept C126322002 @default.
- W4308342303 hasConcept C150903083 @default.
- W4308342303 hasConcept C162324750 @default.
- W4308342303 hasConcept C181389837 @default.
- W4308342303 hasConcept C185592680 @default.
- W4308342303 hasConcept C202751555 @default.
- W4308342303 hasConcept C207001950 @default.
- W4308342303 hasConcept C2780165375 @default.
- W4308342303 hasConcept C2780306303 @default.
- W4308342303 hasConcept C2780427987 @default.
- W4308342303 hasConcept C54400483 @default.
- W4308342303 hasConcept C55493867 @default.
- W4308342303 hasConcept C71924100 @default.
- W4308342303 hasConcept C86803240 @default.
- W4308342303 hasConcept C96232424 @default.
- W4308342303 hasConcept C98274493 @default.
- W4308342303 hasConceptScore W4308342303C10138342 @default.
- W4308342303 hasConceptScore W4308342303C121608353 @default.
- W4308342303 hasConceptScore W4308342303C126322002 @default.
- W4308342303 hasConceptScore W4308342303C150903083 @default.
- W4308342303 hasConceptScore W4308342303C162324750 @default.
- W4308342303 hasConceptScore W4308342303C181389837 @default.
- W4308342303 hasConceptScore W4308342303C185592680 @default.