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• W4308344573 abstract "Complex nanoparticles with hybrid forms of quantum dots and nano-scale templates are highly interesting due to various functionalities and broad applications in point-of-care testing (POCT). High sensitivity and throughput are significant for POCT in clinical applications and food safety, especially for determining multiple targets in complex matrices. Here, we developed the labyrinth-like quantum dot nanobeads (LQDBs) with controlled size, enhanced loading capacity and an intelligent mobile detection format. We reported a smartphone readout using color-selective LQDBs as fluorescent labels for POCT of dual targets in paper-test format. The labyrinth-like nanobeads assembled with QDs provided high colloidal stability, facile functionalization, and a rough surface for more binding sites to monoclonal antibodies enabled by a thin silica layer coating. Using LQDB, the POCT of dual targets was developed assisted with an in-house application on a smartphone. This assay detected aflatoxin B 1 (AFB 1 ) and zearalenone (ZEN) within 10 minutes using a competitive immunoassay. The LODs for urine and agricultural products were recorded as 0.002 and 0.02 ng/mL for AFB 1 and ZEN, respectively. Reasonable specificity, repeatability, reproducibility, and validation results were recorded in real samples. This biosensing platform can be widely suitable in clinical healthcare and food safety applications. • A sensitive smartphone-based intelligent sensing strategy for multiple targets • Labyrinth-like quantum dot nanobeads as fluorescent labels • Multiple mycotoxins detection within 10 min for health care and food safety" @default.
• W4308344573 created "2022-11-11" @default.
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• W4308344573 date "2023-02-01" @default.
• W4308344573 modified "2023-10-01" @default.
• W4308344573 title "Color-selective labyrinth-like quantum dot nanobeads enable point-of-care dual assay of Mycotoxins" @default.
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• W4308344573 doi "https://doi.org/10.1016/j.snb.2022.132956" @default.
• W4308344573 hasPublicationYear "2023" @default.
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