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• W4308346210 abstract "To evaluate the prevalence of autoimmune diseases (AD) associated with type 1 diabetes mellitus (T1DM). Analytical cross-sectional study, nested in a multicenter prospective cohort of 1121 ADults with DM1 with active follow-up in endocrinology clinics. Sociodemographic and clinical variables and the presence of AD were analysed in 2010 and 2020. In this second analysis, 49,5% were male, mean age was 49.4 ± 12.8 years, median T1DM duration was 27,1 years (20,7–35,1) and mean glycated hemoglobin was 7.66 ± 1.06%. There is an absolute increase of 13% (95% CI 11–15) ( P < .001) of patients with at least one AE and an absolute increase of 11.6% (95% CI 9.7–13.5) ( P < .0001) of any type of autoimmune thyroid disease (ATD) after 10 years of follow-up. Likewise, the prevalence of celiac disease, autoimmune gastritis and other AD increased statistically significantly. In the multivariate logistic regression analysis, the factors that were independently associated with the presence of ATD were female gender [OR 2.9 (95% CI 2.3–3.7); P < .0001] and the presence of type 1b diabetes [OR 0.5 (95% CI 0.3–0.9); P = .041]. After 10 years of follow-up, there is a substantial increase in other types of AE in patients with DM1. It seems necessary to carry out a systematic screening of these AD to optimize the follow-up of patients with 1TDM, mainly of the ATD. Conocer la prevalencia de las enfermedades autoinmunes (EA) asociadas a la diabetes mellitus tipo 1 (DM1). Estudio transversal analítico, anidado en una cohorte prospectiva multicéntrica de 1121 ADultos con DM1 con seguimiento activo en consultas de endocrinología. Se analizaron variables sociodemográficas, clínicas y la presencia de EA en el año 2010 y en el año 2020. En este segundo análisis, la edad media fue de 49,4 ± 12,8 años, siendo el 49,5% varones, con una mediana de tiempo de evolución de la DM1 de 27,1 años (20,7–35,1) y una media de hemoglobina glicada de 7,66 ± 1,06%. Existe un incremento absoluto del 13% (IC 95% 11–15) ( P < ,001) de pacientes con al menos una EA y un incremento absoluto de 11,6% (IC 95% 9,7–13,5) ( P < ,0001) de cualquier tipo de enfermedad tiroidea autoinmune (ETA) tras 10 años de seguimiento. Así mismo, aumentó la prevalencia de manera estadísticamente significativa de la gastritis autoinmune, enfermedad celiaca y otras EA. En el análisis de regresión logística multivariante, los factores que se asociaron de manera independiente a la presencia de ETA fueron el género femenino [OR 2,9 (IC 95% 2,3–3,7); P < ,0001] y la DM1 tipo b [OR 0,5 (IC 95% 0,3–0,9); P = ,041]. Tras 10 años de seguimiento activo se produce un incremento sustancial de otro tipo de EA en pacientes con DM1. Parece necesario realizar un cribado sistemático de dichas EA para optimizar el seguimiento de los pacientes con DM1, fundamentalmente de la ETA." @default.
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• W4308346210 date "2022-12-01" @default.
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• W4308346210 title "Prevalence of autoimmune diseases in patients with type 1 diabetes mellitus. DIACAM 1 study 2010–2020" @default.
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• W4308346210 doi "https://doi.org/10.1016/j.medcle.2022.01.023" @default.
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