Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308352510> ?p ?o ?g. }
- W4308352510 endingPage "1533" @default.
- W4308352510 startingPage "1533" @default.
- W4308352510 abstract "The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. The endophytic fungi Graminicolous helminthosporium, Bipolaris australiensis and Cladosporium cladosporioides were isolated from different medicinal plants. The GC-MS analysis of intra- and extracellular products of endophytic fungi revealed the presence of various bioactive metabolites, such as Anthracene, Brallobarbital, Benzo [h] quinolone, Ethylacridine, 2-Ethylacridine, Cyclotrisiloxane, 5 methyl 2 phenylindolizine, and 1,4-Cyclohexadien-1-one, etc. The phytochemical composition analysis of endophytic fungus extracts also revealed the presence of flavonoids, phenols, saponins, carbohydrates, glycosides, and proteins. The intra- and extracellular endophytic extracts exhibited strong antibacterial and antioxidant activity, which was screened with the agar-well diffusion method and DPPH, H2O2, and nitric oxide scavenging activity, respectively. The bioactive compounds identified in the endophytic extracts from GC-MS profiling served as ligands for molecular-docking analysis to investigate the anticancer potential against non-small cell lung carcinoma receptor EGFR. Molecular docking results showed that compounds, such as Brallobarbital, and 5 methyl 2 phenylindolizine had the lowest E- min values, which suggests that these compounds could be used in anticancer drug development. Thus, the isolated endophytic fungal species can be used to produce various bioactive compounds that could be used in novel drug development from natural sources and reduce the environmental burden of synthetic chemical drugs." @default.
- W4308352510 created "2022-11-11" @default.
- W4308352510 creator A5006077100 @default.
- W4308352510 creator A5007141173 @default.
- W4308352510 creator A5008513668 @default.
- W4308352510 creator A5050035322 @default.
- W4308352510 creator A5056837397 @default.
- W4308352510 creator A5072732464 @default.
- W4308352510 creator A5073757694 @default.
- W4308352510 creator A5080681588 @default.
- W4308352510 creator A5082594103 @default.
- W4308352510 creator A5085997551 @default.
- W4308352510 date "2022-11-02" @default.
- W4308352510 modified "2023-10-01" @default.
- W4308352510 title "Bioactive Components and Health Potential of Endophytic Micro-Fungal Diversity in Medicinal Plants" @default.
- W4308352510 cites W1837617056 @default.
- W4308352510 cites W1965997602 @default.
- W4308352510 cites W1976702173 @default.
- W4308352510 cites W2099556958 @default.
- W4308352510 cites W2101646044 @default.
- W4308352510 cites W2104853718 @default.
- W4308352510 cites W2158931978 @default.
- W4308352510 cites W2185564569 @default.
- W4308352510 cites W2314300835 @default.
- W4308352510 cites W2525935907 @default.
- W4308352510 cites W2804158466 @default.
- W4308352510 cites W2885437828 @default.
- W4308352510 cites W2971597534 @default.
- W4308352510 cites W2996831551 @default.
- W4308352510 cites W3007809183 @default.
- W4308352510 cites W3023516177 @default.
- W4308352510 cites W3025260468 @default.
- W4308352510 cites W3045950590 @default.
- W4308352510 cites W3083542903 @default.
- W4308352510 cites W3107928415 @default.
- W4308352510 cites W3120823233 @default.
- W4308352510 cites W3123918712 @default.
- W4308352510 cites W3126813390 @default.
- W4308352510 cites W3173110118 @default.
- W4308352510 cites W4250188742 @default.
- W4308352510 cites W4294540925 @default.
- W4308352510 doi "https://doi.org/10.3390/antibiotics11111533" @default.
- W4308352510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36358188" @default.
- W4308352510 hasPublicationYear "2022" @default.
- W4308352510 type Work @default.
- W4308352510 citedByCount "5" @default.
- W4308352510 countsByYear W43083525102023 @default.
- W4308352510 crossrefType "journal-article" @default.
- W4308352510 hasAuthorship W4308352510A5006077100 @default.
- W4308352510 hasAuthorship W4308352510A5007141173 @default.
- W4308352510 hasAuthorship W4308352510A5008513668 @default.
- W4308352510 hasAuthorship W4308352510A5050035322 @default.
- W4308352510 hasAuthorship W4308352510A5056837397 @default.
- W4308352510 hasAuthorship W4308352510A5072732464 @default.
- W4308352510 hasAuthorship W4308352510A5073757694 @default.
- W4308352510 hasAuthorship W4308352510A5080681588 @default.
- W4308352510 hasAuthorship W4308352510A5082594103 @default.
- W4308352510 hasAuthorship W4308352510A5085997551 @default.
- W4308352510 hasBestOaLocation W43083525101 @default.
- W4308352510 hasConcept C185592680 @default.
- W4308352510 hasConcept C195475562 @default.
- W4308352510 hasConcept C2778004101 @default.
- W4308352510 hasConcept C2779158651 @default.
- W4308352510 hasConcept C2779311684 @default.
- W4308352510 hasConcept C2781401929 @default.
- W4308352510 hasConcept C55493867 @default.
- W4308352510 hasConcept C556039675 @default.
- W4308352510 hasConcept C59822182 @default.
- W4308352510 hasConcept C71924100 @default.
- W4308352510 hasConcept C86803240 @default.
- W4308352510 hasConcept C89638049 @default.
- W4308352510 hasConceptScore W4308352510C185592680 @default.
- W4308352510 hasConceptScore W4308352510C195475562 @default.
- W4308352510 hasConceptScore W4308352510C2778004101 @default.
- W4308352510 hasConceptScore W4308352510C2779158651 @default.
- W4308352510 hasConceptScore W4308352510C2779311684 @default.
- W4308352510 hasConceptScore W4308352510C2781401929 @default.
- W4308352510 hasConceptScore W4308352510C55493867 @default.
- W4308352510 hasConceptScore W4308352510C556039675 @default.
- W4308352510 hasConceptScore W4308352510C59822182 @default.
- W4308352510 hasConceptScore W4308352510C71924100 @default.
- W4308352510 hasConceptScore W4308352510C86803240 @default.
- W4308352510 hasConceptScore W4308352510C89638049 @default.
- W4308352510 hasIssue "11" @default.
- W4308352510 hasLocation W43083525101 @default.
- W4308352510 hasLocation W43083525102 @default.
- W4308352510 hasLocation W43083525103 @default.
- W4308352510 hasOpenAccess W4308352510 @default.
- W4308352510 hasPrimaryLocation W43083525101 @default.
- W4308352510 hasRelatedWork W2113163436 @default.
- W4308352510 hasRelatedWork W2185640092 @default.
- W4308352510 hasRelatedWork W2218888177 @default.
- W4308352510 hasRelatedWork W2489030968 @default.
- W4308352510 hasRelatedWork W2617523712 @default.
- W4308352510 hasRelatedWork W2741404071 @default.
- W4308352510 hasRelatedWork W4285726623 @default.
- W4308352510 hasRelatedWork W4381283993 @default.
- W4308352510 hasRelatedWork W3046302942 @default.