Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308354650> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4308354650 endingPage "34" @default.
- W4308354650 startingPage "31" @default.
- W4308354650 abstract "The recognition that sepsis induces acute kidney injury (AKI) in the absence of overt necrosis or apoptosis and even in the presence of increased renal blood flow has led to the consideration that kidney tubular epithelial cells (TECs) may deploy defense mechanisms to survive the insult.This concept dovetails well with the notion that the defense against infection not only depends on the capacity of the immune system to limit the microbial burden or resistance capacity but also on the capacity of the host to limit tissue injury, collectively known as tolerance. To sustain the high energy requirement that ion transport mandates, kidney TECs use fatty acid oxidation (FAO) as one of the preferred sources of energy. Inflammatory processes like endotoxemia and sepsis decrease mitochondrial FAO and hinder mitochondrial respiration. Impaired FAO is associated with TEC de-differentiation, loss of kidney function, and TEC injury through lipotoxicity and oxidative stress in the acute setting, and with maladaptive repair and fibrosis after AKI in the latter stages. AMP-activated protein kinase (AMPK) is a master regulator of energy and promoter of FAO that can be activated pharmacologically to protect against AKI and death during experimental sepsis, operating through a tolerance mechanism.Organ dysfunction during sepsis is the expression of tissue injury and adaptive defense mechanisms operating through resistance or tolerance that prioritize cell survival over organ function. Metabolic reprogramming away from FAO/oxidative phosphorylation seems to be a common pathological denominator throughout the AKI continuum that may be targeted through the activation of AMPK." @default.
- W4308354650 created "2022-11-11" @default.
- W4308354650 creator A5002956220 @default.
- W4308354650 date "2022-11-04" @default.
- W4308354650 modified "2023-10-15" @default.
- W4308354650 title "Reprogramming Metabolism to Enhance Kidney Tolerance during Sepsis: The Role of Fatty Acid Oxidation, Aerobic Glycolysis, and Epithelial De-Differentiation" @default.
- W4308354650 cites W1744619657 @default.
- W4308354650 cites W1911315538 @default.
- W4308354650 cites W2000013518 @default.
- W4308354650 cites W2025193748 @default.
- W4308354650 cites W2043931994 @default.
- W4308354650 cites W2050622384 @default.
- W4308354650 cites W2056109978 @default.
- W4308354650 cites W2059596972 @default.
- W4308354650 cites W2060267424 @default.
- W4308354650 cites W2088009584 @default.
- W4308354650 cites W2131018427 @default.
- W4308354650 cites W2164793313 @default.
- W4308354650 cites W2195479774 @default.
- W4308354650 cites W2750514629 @default.
- W4308354650 cites W2788432017 @default.
- W4308354650 cites W2809239433 @default.
- W4308354650 cites W2921646079 @default.
- W4308354650 cites W2995364895 @default.
- W4308354650 cites W3014915090 @default.
- W4308354650 cites W3035235416 @default.
- W4308354650 cites W3122688842 @default.
- W4308354650 cites W3199684391 @default.
- W4308354650 doi "https://doi.org/10.1159/000527392" @default.
- W4308354650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36349802" @default.
- W4308354650 hasPublicationYear "2022" @default.
- W4308354650 type Work @default.
- W4308354650 citedByCount "3" @default.
- W4308354650 countsByYear W43083546502023 @default.
- W4308354650 crossrefType "journal-article" @default.
- W4308354650 hasAuthorship W4308354650A5002956220 @default.
- W4308354650 hasBestOaLocation W43083546501 @default.
- W4308354650 hasConcept C126322002 @default.
- W4308354650 hasConcept C184235292 @default.
- W4308354650 hasConcept C20251656 @default.
- W4308354650 hasConcept C2778384902 @default.
- W4308354650 hasConcept C2780091579 @default.
- W4308354650 hasConcept C2780124434 @default.
- W4308354650 hasConcept C2780472472 @default.
- W4308354650 hasConcept C502942594 @default.
- W4308354650 hasConcept C62231903 @default.
- W4308354650 hasConcept C71924100 @default.
- W4308354650 hasConcept C82714985 @default.
- W4308354650 hasConcept C86803240 @default.
- W4308354650 hasConcept C95444343 @default.
- W4308354650 hasConcept C97029542 @default.
- W4308354650 hasConceptScore W4308354650C126322002 @default.
- W4308354650 hasConceptScore W4308354650C184235292 @default.
- W4308354650 hasConceptScore W4308354650C20251656 @default.
- W4308354650 hasConceptScore W4308354650C2778384902 @default.
- W4308354650 hasConceptScore W4308354650C2780091579 @default.
- W4308354650 hasConceptScore W4308354650C2780124434 @default.
- W4308354650 hasConceptScore W4308354650C2780472472 @default.
- W4308354650 hasConceptScore W4308354650C502942594 @default.
- W4308354650 hasConceptScore W4308354650C62231903 @default.
- W4308354650 hasConceptScore W4308354650C71924100 @default.
- W4308354650 hasConceptScore W4308354650C82714985 @default.
- W4308354650 hasConceptScore W4308354650C86803240 @default.
- W4308354650 hasConceptScore W4308354650C95444343 @default.
- W4308354650 hasConceptScore W4308354650C97029542 @default.
- W4308354650 hasIssue "1" @default.
- W4308354650 hasLocation W43083546501 @default.
- W4308354650 hasLocation W43083546502 @default.
- W4308354650 hasOpenAccess W4308354650 @default.
- W4308354650 hasPrimaryLocation W43083546501 @default.
- W4308354650 hasRelatedWork W2039051647 @default.
- W4308354650 hasRelatedWork W2081914730 @default.
- W4308354650 hasRelatedWork W2082388539 @default.
- W4308354650 hasRelatedWork W2112959575 @default.
- W4308354650 hasRelatedWork W2350237293 @default.
- W4308354650 hasRelatedWork W2984017515 @default.
- W4308354650 hasRelatedWork W3098122996 @default.
- W4308354650 hasRelatedWork W3175345897 @default.
- W4308354650 hasRelatedWork W4321442582 @default.
- W4308354650 hasRelatedWork W4324130264 @default.
- W4308354650 hasVolume "147" @default.
- W4308354650 isParatext "false" @default.
- W4308354650 isRetracted "false" @default.
- W4308354650 workType "article" @default.