Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308356804> ?p ?o ?g. }
- W4308356804 abstract "Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid synthesis during tumorigenesis is almost unknown. Herein, we show that ROS regulates lipid synthesis and thus controls colorectal tumorigenesis through a p53-dependent mechanism. In p53 wild-type colorectal cancer (CRC) cells, hydrogen peroxide (H2O2)-induced p53 expression represses the transcription of deubiquitinase USP22, which otherwise deubiquitinates and stabilizes Fatty Acid Synthase (FASN), and thus inhibits fatty acid synthesis. Whereas, in p53-deficient CRC cells, ROS-mediated inhibition of USP22 is relieved, leading to FASN stabilization, which thus promotes lipid synthesis and tumor growth. In human CRC specimens, USP22 expression is positively correlated with FASN expression. Our study demonstrates that ROS critically regulates lipid synthesis and tumorigenesis through the USP22-FASN axis in a p53-dependent manner, and targeting the USP22-FASN axis may represent a potential strategy for the treatment of colorectal cancer." @default.
- W4308356804 created "2022-11-11" @default.
- W4308356804 creator A5002857288 @default.
- W4308356804 creator A5005085624 @default.
- W4308356804 creator A5007520825 @default.
- W4308356804 creator A5012278873 @default.
- W4308356804 creator A5022310050 @default.
- W4308356804 creator A5029510472 @default.
- W4308356804 creator A5039701790 @default.
- W4308356804 creator A5041081475 @default.
- W4308356804 creator A5045779549 @default.
- W4308356804 creator A5055029433 @default.
- W4308356804 creator A5059272058 @default.
- W4308356804 creator A5064191339 @default.
- W4308356804 creator A5064831934 @default.
- W4308356804 creator A5070480239 @default.
- W4308356804 creator A5080137753 @default.
- W4308356804 creator A5090569224 @default.
- W4308356804 creator A5009963396 @default.
- W4308356804 date "2022-11-04" @default.
- W4308356804 modified "2023-10-15" @default.
- W4308356804 title "Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis" @default.
- W4308356804 cites W1980456818 @default.
- W4308356804 cites W1999816037 @default.
- W4308356804 cites W2029828909 @default.
- W4308356804 cites W2055900062 @default.
- W4308356804 cites W2088621072 @default.
- W4308356804 cites W2098131661 @default.
- W4308356804 cites W2124446528 @default.
- W4308356804 cites W2142252299 @default.
- W4308356804 cites W2150144117 @default.
- W4308356804 cites W2154260730 @default.
- W4308356804 cites W2266158144 @default.
- W4308356804 cites W2506924177 @default.
- W4308356804 cites W2516807201 @default.
- W4308356804 cites W2523687917 @default.
- W4308356804 cites W2604403946 @default.
- W4308356804 cites W2607120474 @default.
- W4308356804 cites W2621333085 @default.
- W4308356804 cites W2712489347 @default.
- W4308356804 cites W2760001608 @default.
- W4308356804 cites W2767326431 @default.
- W4308356804 cites W2833129054 @default.
- W4308356804 cites W2899910765 @default.
- W4308356804 cites W2903112818 @default.
- W4308356804 cites W2906819127 @default.
- W4308356804 cites W2909113451 @default.
- W4308356804 cites W2913562025 @default.
- W4308356804 cites W2913564359 @default.
- W4308356804 cites W2990971331 @default.
- W4308356804 cites W2992324722 @default.
- W4308356804 cites W3005689864 @default.
- W4308356804 cites W3007389146 @default.
- W4308356804 cites W3013352992 @default.
- W4308356804 cites W3041426930 @default.
- W4308356804 cites W3046244298 @default.
- W4308356804 cites W3107573771 @default.
- W4308356804 cites W3111224257 @default.
- W4308356804 cites W3178136091 @default.
- W4308356804 doi "https://doi.org/10.1038/s41420-022-01241-9" @default.
- W4308356804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36333288" @default.
- W4308356804 hasPublicationYear "2022" @default.
- W4308356804 type Work @default.
- W4308356804 citedByCount "1" @default.
- W4308356804 countsByYear W43083568042023 @default.
- W4308356804 crossrefType "journal-article" @default.
- W4308356804 hasAuthorship W4308356804A5002857288 @default.
- W4308356804 hasAuthorship W4308356804A5005085624 @default.
- W4308356804 hasAuthorship W4308356804A5007520825 @default.
- W4308356804 hasAuthorship W4308356804A5009963396 @default.
- W4308356804 hasAuthorship W4308356804A5012278873 @default.
- W4308356804 hasAuthorship W4308356804A5022310050 @default.
- W4308356804 hasAuthorship W4308356804A5029510472 @default.
- W4308356804 hasAuthorship W4308356804A5039701790 @default.
- W4308356804 hasAuthorship W4308356804A5041081475 @default.
- W4308356804 hasAuthorship W4308356804A5045779549 @default.
- W4308356804 hasAuthorship W4308356804A5055029433 @default.
- W4308356804 hasAuthorship W4308356804A5059272058 @default.
- W4308356804 hasAuthorship W4308356804A5064191339 @default.
- W4308356804 hasAuthorship W4308356804A5064831934 @default.
- W4308356804 hasAuthorship W4308356804A5070480239 @default.
- W4308356804 hasAuthorship W4308356804A5080137753 @default.
- W4308356804 hasAuthorship W4308356804A5090569224 @default.
- W4308356804 hasBestOaLocation W43083568041 @default.
- W4308356804 hasConcept C104317684 @default.
- W4308356804 hasConcept C121608353 @default.
- W4308356804 hasConcept C141359234 @default.
- W4308356804 hasConcept C185592680 @default.
- W4308356804 hasConcept C2776151105 @default.
- W4308356804 hasConcept C4733338 @default.
- W4308356804 hasConcept C48289651 @default.
- W4308356804 hasConcept C48349386 @default.
- W4308356804 hasConcept C502942594 @default.
- W4308356804 hasConcept C526805850 @default.
- W4308356804 hasConcept C54355233 @default.
- W4308356804 hasConcept C55493867 @default.
- W4308356804 hasConcept C555283112 @default.
- W4308356804 hasConcept C86803240 @default.
- W4308356804 hasConcept C95444343 @default.
- W4308356804 hasConcept C96232424 @default.