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• W4308364418 endingPage "20553" @default.
• W4308364418 startingPage "20550" @default.
• W4308364418 abstract "Ligand development has enabled rapid advances in Pd(II)-catalyzed β-methyl C(sp3)-H activation of free carboxylic acids. However, there are only a handful of reports of free-acid-directed β-methylene C(sp3)-H activation, all of which are limited to intramolecular reactions. Herein, we report the first Pd(II)-catalyzed intermolecular β-methylene C(sp3)-H arylation of free aliphatic acids, which is enabled by bidentate pyridine-pyridone ligands. The bite angle of this ligand has been discovered to play a key role in promoting β-methylene C-H activation of free carboxylic acid. This new transformation provides a disconnection for alkylation of arenes with simple aliphatic acids. A variety of free aliphatic acids, including the antiasthmatic drug seratrodast, were compatible with the reported protocol." @default.
• W4308364418 created "2022-11-11" @default.
• W4308364418 creator A5009521293 @default.
• W4308364418 creator A5070628814 @default.
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• W4308364418 date "2022-11-07" @default.
• W4308364418 modified "2023-09-30" @default.
• W4308364418 title "Ligand-Enabled Pd(II)-Catalyzed β-Methylene C(sp³)–H Arylation of Free Aliphatic Acids" @default.
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• W4308364418 doi "https://doi.org/10.1021/jacs.2c09205" @default.
• W4308364418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36342466" @default.
• W4308364418 hasPublicationYear "2022" @default.
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