Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308364598> ?p ?o ?g. }
- W4308364598 abstract "Among the known hydrosilylation or carbosilylation conditions of alkynes, anti-addition of the two units across the triple bond is considered rare compared to the syn counterpart. For anti-silylative vicinal difunctionalizations, transition-metal catalysts, such as ruthenium or palladium complexes, are generally required. Accordingly, silyl alkali metals have not been employed for those anti-addition transformations. Here we demonstrate that silyllithiums can add across the triple bond of a series of propargylic alkoxides regioselectively in an anti-fashion. Upon treatment with a variety of electrophiles, the trisubstituted alkenyl lithium intermediates were transformed into highly functionalized β-silyl allylic alcohols with high regiocontrol, eventually providing tri- or tetrasubstituted alkenylsilanes stereoselectively. A classic trick for anti-addition with propargylic alkoxides has transformed anti-silylative functionalizations into a robust and reliable strategy." @default.
- W4308364598 created "2022-11-11" @default.
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- W4308364598 date "2022-11-07" @default.
- W4308364598 modified "2023-10-14" @default.
- W4308364598 title "Regioselective <i>Anti</i>-Silyllithiation of Propargylic Alcohols" @default.
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- W4308364598 doi "https://doi.org/10.1021/acs.joc.2c01795" @default.
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