Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308365535> ?p ?o ?g. }
- W4308365535 endingPage "129" @default.
- W4308365535 startingPage "119" @default.
- W4308365535 abstract "TCF3 is a lymphopoietic transcription factor that acquires somatic driver mutations in diffuse large B-cell lymphoma (DLBCL). Hypothesizing that expression patterns of TCF3-regulated genes can inform clinical management, we found that unsupervised clustering analysis with 15 TCF3-regulated genes and eight additional ones resolved local DLBCL cases into two main clusters, denoted Groups A and B, of which Group A manifested inferior overall survival (OS, p = 0.0005). We trained a machine learning model to classify samples into the Groups based on expression of the 23 transcripts in an independent validation cohort of 569 R-CHOP-treated DLBCL cases. Group A overlapped with the ABC cell-of-origin subgroup but its prognostic power was superior. GSEA analysis demonstrated asymmetric expression of 30 gene sets between the Groups, pointing to biological differences. We present, validate and make available a novel method to assign DLBCL cases into biologically-distinct groups with divergent OS following R-CHOP therapy." @default.
- W4308365535 created "2022-11-11" @default.
- W4308365535 creator A5006292181 @default.
- W4308365535 creator A5018929375 @default.
- W4308365535 creator A5024852195 @default.
- W4308365535 creator A5026075949 @default.
- W4308365535 creator A5060734291 @default.
- W4308365535 creator A5079256721 @default.
- W4308365535 creator A5086014959 @default.
- W4308365535 creator A5086588458 @default.
- W4308365535 date "2022-11-06" @default.
- W4308365535 modified "2023-10-17" @default.
- W4308365535 title "Expression of TCF3 target genes defines a subclass of diffuse large B-cell lymphoma characterized by up-regulation of MYC target genes and poor clinical outcome following R-CHOP therapy" @default.
- W4308365535 cites W1502318498 @default.
- W4308365535 cites W1580316172 @default.
- W4308365535 cites W1969582706 @default.
- W4308365535 cites W1976564639 @default.
- W4308365535 cites W1996473695 @default.
- W4308365535 cites W2016446434 @default.
- W4308365535 cites W2037796411 @default.
- W4308365535 cites W2038023916 @default.
- W4308365535 cites W2039255446 @default.
- W4308365535 cites W2050216123 @default.
- W4308365535 cites W2064208261 @default.
- W4308365535 cites W2068343048 @default.
- W4308365535 cites W2069590838 @default.
- W4308365535 cites W2070217465 @default.
- W4308365535 cites W2075158261 @default.
- W4308365535 cites W2114154892 @default.
- W4308365535 cites W2118028844 @default.
- W4308365535 cites W2120532570 @default.
- W4308365535 cites W2121862242 @default.
- W4308365535 cites W2130410032 @default.
- W4308365535 cites W2133201432 @default.
- W4308365535 cites W2136268782 @default.
- W4308365535 cites W2139676849 @default.
- W4308365535 cites W2139954541 @default.
- W4308365535 cites W2140065103 @default.
- W4308365535 cites W2147246240 @default.
- W4308365535 cites W2151624656 @default.
- W4308365535 cites W2158267770 @default.
- W4308365535 cites W2170989872 @default.
- W4308365535 cites W2214074259 @default.
- W4308365535 cites W2552031241 @default.
- W4308365535 cites W2554101924 @default.
- W4308365535 cites W2614435853 @default.
- W4308365535 cites W2624620803 @default.
- W4308365535 cites W2744261860 @default.
- W4308365535 cites W2762450632 @default.
- W4308365535 cites W2775090033 @default.
- W4308365535 cites W2795144213 @default.
- W4308365535 cites W2800080453 @default.
- W4308365535 cites W2801763724 @default.
- W4308365535 cites W2892232261 @default.
- W4308365535 cites W2917636259 @default.
- W4308365535 cites W2917960955 @default.
- W4308365535 cites W2971474936 @default.
- W4308365535 cites W3000559214 @default.
- W4308365535 cites W3039476641 @default.
- W4308365535 cites W3107258097 @default.
- W4308365535 cites W4250504452 @default.
- W4308365535 cites W4293680078 @default.
- W4308365535 doi "https://doi.org/10.1080/10428194.2022.2136968" @default.
- W4308365535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336953" @default.
- W4308365535 hasPublicationYear "2022" @default.
- W4308365535 type Work @default.
- W4308365535 citedByCount "0" @default.
- W4308365535 crossrefType "journal-article" @default.
- W4308365535 hasAuthorship W4308365535A5006292181 @default.
- W4308365535 hasAuthorship W4308365535A5018929375 @default.
- W4308365535 hasAuthorship W4308365535A5024852195 @default.
- W4308365535 hasAuthorship W4308365535A5026075949 @default.
- W4308365535 hasAuthorship W4308365535A5060734291 @default.
- W4308365535 hasAuthorship W4308365535A5079256721 @default.
- W4308365535 hasAuthorship W4308365535A5086014959 @default.
- W4308365535 hasAuthorship W4308365535A5086588458 @default.
- W4308365535 hasConcept C104317684 @default.
- W4308365535 hasConcept C126322002 @default.
- W4308365535 hasConcept C143998085 @default.
- W4308365535 hasConcept C203014093 @default.
- W4308365535 hasConcept C2778559949 @default.
- W4308365535 hasConcept C2779338263 @default.
- W4308365535 hasConcept C2779725641 @default.
- W4308365535 hasConcept C502942594 @default.
- W4308365535 hasConcept C54355233 @default.
- W4308365535 hasConcept C60644358 @default.
- W4308365535 hasConcept C71924100 @default.
- W4308365535 hasConcept C86339819 @default.
- W4308365535 hasConcept C86803240 @default.
- W4308365535 hasConceptScore W4308365535C104317684 @default.
- W4308365535 hasConceptScore W4308365535C126322002 @default.
- W4308365535 hasConceptScore W4308365535C143998085 @default.
- W4308365535 hasConceptScore W4308365535C203014093 @default.
- W4308365535 hasConceptScore W4308365535C2778559949 @default.
- W4308365535 hasConceptScore W4308365535C2779338263 @default.
- W4308365535 hasConceptScore W4308365535C2779725641 @default.
- W4308365535 hasConceptScore W4308365535C502942594 @default.
- W4308365535 hasConceptScore W4308365535C54355233 @default.