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- W4308365854 abstract "The essential oil extracted from the leaves of Piper aduncum has antifungal, insecticidal and antibacterial activity. Studies with its main compound, dillapiole (DIL) revealed antibacterial and anti-inflammatory potential. Despite all this bioactivity, there is no updated report on the development and validation of analytical and bioanalytical methodology to quantify DIL in skin samples. A selective, precise, accurate and adequate method for the determination of DIL in solutions, porcine ear skin samples and receptor fluid was developed and validated by Headspace-Gas Chromatography with Flame Ionization Detector (HS-GC-FID). HS-GC-FID was applied to determine DIL in Franz cell permeation and retention studies using porcine ear skin samples. In the HS-CG-FID method, matrix-related interferences were not observed at the peak of the DIL retention time. The results showed a high recovery (> 97%) after the extraction procedure, allowing the quantification of DIL in complex matrices. In vitro permeation/retention for DIL, showed cumulative amount permeated in the order: receptor fluid (21.98 ±1.19 μg/cm2) > epidermis (15.40 ±1.20 μg/cm2) > dermis (9.52 ±1.13 μg/cm2). HS-GC-FID was successfully validated and results point to DIL transdermal permeation and to the potential to develop pharmaceutical formulations for skin delivery to treat inflammation or infections." @default.
- W4308365854 created "2022-11-11" @default.
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- W4308365854 date "2022-11-23" @default.
- W4308365854 modified "2023-09-29" @default.
- W4308365854 title "Development, validation and application of a gas chromatography method for the determination of dillapiole from <scp> <i>Piper aduncum</i> </scp> essential oil in skin permeation samples" @default.
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- W4308365854 doi "https://doi.org/10.1002/bmc.5544" @default.
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