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- W4308366167 abstract "Carcinoembryonic antigen (CEA) is regarded as a promising broad spectrum tumor biomarker for clinical diagnosis, progression, and prognosis. Surface plasmon resonance imaging (SPRi) was considered as one of the powerful tools for immunoassay with advantages of label-free, real-time detection with high-throughput. Herein, wavy gold-silver alloy nanoplates functionalized with anti-CEA antibodies providing high protein loading capacity and high mass are used as signal enhancers for CEA detection through SPRi sandwich assay. The present method exhibits a dynamic range for CEA determination from 0.1 to 312.5 ng mL-1 and a detection limit of 0.55 ng mL-1, well below normal physiological levels. This biosensing approach demonstrates the advantages of wavy gold-silver alloy nanoplates compared to conventional gold nanoparticles as a signal amplifier to enhance the SPRi signal, which is expected to become a new prospect for detection of cancer markers in biomedical research and clinical diagnosis." @default.
- W4308366167 created "2022-11-11" @default.
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- W4308366167 date "2022-01-01" @default.
- W4308366167 modified "2023-10-16" @default.
- W4308366167 title "Detection of carcinoembryonic antigens using a wavy gold–silver alloy nanoplate enhanced surface plasmon resonance imaging biosensor" @default.
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- W4308366167 doi "https://doi.org/10.1039/d2ay01523d" @default.
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