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- W4308366195 abstract "Background: Vascular calcification (VC) is a serious pathological manifestation of vascular terminals and is an important pathological basis of cardiovascular diseases in patients with end-stage renal disease (ESRD). This study explored the clinical value of serum microRNA-211-5p (miR-211-5p) in VC in patients with ESRD, this study was designed. Methods: The relative expression of miR-211-5p in the serum of the calcified group and the non-calcified group was quantified by quantitative reverse transcription polymerase chain reaction. The clinical biochemical indexes and the expression differences in miR-211-5p expression in the serum of groups were compared by two independent samples <i>t</i>-test or nonparametric test or one-way analysis of variance test. The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR-211-5p in patients with ESRD. Results: The relative quantification of serum miR-211-5p was lessened in calcified group and gradually decreased with the progression of VC. Serum miR-211-5p had a high diagnostic accuracy in the diagnosis of VC progression in ESRD patients. Kaplan-Meier and Cox regression methods revealed that miR-211-5p might be an independent biomarker for prognosis of ESRD patients. Conclusions: MiR-211-5p is a potential diagnostic and prognostic marker of VC in patients with ESRD." @default.
- W4308366195 created "2022-11-11" @default.
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- W4308366195 date "2022-01-01" @default.
- W4308366195 modified "2023-10-18" @default.
- W4308366195 title "MicroRNA-211-5p as a Biomarker in Early Detection of Uremic Vascular Calcification among Patients with End‐Stage Renal Disease" @default.
- W4308366195 doi "https://doi.org/10.56434/j.arch.esp.urol.20227508.103" @default.
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