FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308366960> ?p ?o ?g. }

• W4308366960 endingPage "341" @default.
• W4308366960 startingPage "333" @default.
• W4308366960 abstract "Several imaging modalities have been employed to quantify lung dose and the distribution of the dose of orally inhaled aerosols in vivo. Two-dimensional (2D, or planar) imaging using gamma scintigraphy is the most widely used of these modalities. Two-dimensional gamma scintigraphy studies are accomplished using a single- or dual-headed gamma camera. The formulation to be tested is admixed with the gamma emitting radioisotope 99mtechnetium, which serves as a surrogate for the drug. This article provides details as to how 2D gamma scintigraphy images should be acquired and analyzed using recently standardized methods. Based on the new guidelines, the investigator should confirm that the drug formulation is unchanged with the addition of the radioisotope, determine the amount of radioactivity needed for inhalation to obtain appropriate radioactivity counts in the lungs, perform quality control procedures for the gamma camera, identify the lung borders of the study subject using a reference image such as an X-ray computed tomography scan, a ventilation scan, or a transmission scan, acquire a lung transmission image to correct for attenuation of radioactivity by lung tissue, instruct the subject how to inhale the radiolabel-drug mixture and record associated breathing parameters, acquire anterior and/or posterior views of the lungs and any other regions of interest (i.e., oropharynx, stomach) and assess the acquired images for total and regional dose to the lungs. Total dose should be assessed after identification of the right lung border and appropriate correction for tissue attenuation. Regional dose should be quantified as a normalized outer/inner deposition ratio (O/I) and expressed as the penetration index (PI). Mass balance should be performed as needed. By following the standardized methods, 2D gamma scintigraphy data from studies in different laboratories may be compared and combined, leading to multi-center studies and more rapid development of new medications and devices for inhaled therapies." @default.
• W4308366960 created "2022-11-11" @default.
• W4308366960 creator A5078993877 @default.
• W4308366960 date "2022-12-01" @default.
• W4308366960 modified "2023-10-16" @default.
• W4308366960 title "Imaging Aerosol Deposition with Two-Dimensional Gamma Scintigraphy" @default.
• W4308366960 cites W1980824636 @default.
• W4308366960 cites W1988976153 @default.
• W4308366960 cites W2009947229 @default.
• W4308366960 cites W2011898209 @default.
• W4308366960 cites W2018899635 @default.
• W4308366960 cites W2019677635 @default.
• W4308366960 cites W2020462662 @default.
• W4308366960 cites W2022527223 @default.
• W4308366960 cites W2027279298 @default.
• W4308366960 cites W2033241761 @default.
• W4308366960 cites W2037439783 @default.
• W4308366960 cites W2038301940 @default.
• W4308366960 cites W2040116689 @default.
• W4308366960 cites W2042010427 @default.
• W4308366960 cites W2042154117 @default.
• W4308366960 cites W2045523375 @default.
• W4308366960 cites W2067048563 @default.
• W4308366960 cites W2068098591 @default.
• W4308366960 cites W2068758737 @default.
• W4308366960 cites W2069811863 @default.
• W4308366960 cites W2081329706 @default.
• W4308366960 cites W2083839864 @default.
• W4308366960 cites W2084405887 @default.
• W4308366960 cites W2093852073 @default.
• W4308366960 cites W2109937935 @default.
• W4308366960 cites W2110305797 @default.
• W4308366960 cites W2116478659 @default.
• W4308366960 cites W2118957675 @default.
• W4308366960 cites W2165360077 @default.
• W4308366960 cites W2167811134 @default.
• W4308366960 cites W2333620606 @default.
• W4308366960 cites W2590124738 @default.
• W4308366960 cites W4249240163 @default.
• W4308366960 doi "https://doi.org/10.1089/jamp.2022.29072.bll" @default.
• W4308366960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36342668" @default.
• W4308366960 hasPublicationYear "2022" @default.
• W4308366960 type Work @default.
• W4308366960 citedByCount "0" @default.
• W4308366960 crossrefType "journal-article" @default.
• W4308366960 hasAuthorship W4308366960A5078993877 @default.
• W4308366960 hasConcept C115961682 @default.
• W4308366960 hasConcept C120665830 @default.
• W4308366960 hasConcept C121332964 @default.
• W4308366960 hasConcept C123688308 @default.
• W4308366960 hasConcept C126322002 @default.
• W4308366960 hasConcept C126838900 @default.
• W4308366960 hasConcept C154945302 @default.
• W4308366960 hasConcept C184652730 @default.
• W4308366960 hasConcept C2775842073 @default.
• W4308366960 hasConcept C2777714996 @default.
• W4308366960 hasConcept C2779610220 @default.
• W4308366960 hasConcept C2779902710 @default.
• W4308366960 hasConcept C2989005 @default.
• W4308366960 hasConcept C41008148 @default.
• W4308366960 hasConcept C55020928 @default.
• W4308366960 hasConcept C71924100 @default.
• W4308366960 hasConceptScore W4308366960C115961682 @default.
• W4308366960 hasConceptScore W4308366960C120665830 @default.
• W4308366960 hasConceptScore W4308366960C121332964 @default.
• W4308366960 hasConceptScore W4308366960C123688308 @default.
• W4308366960 hasConceptScore W4308366960C126322002 @default.
• W4308366960 hasConceptScore W4308366960C126838900 @default.
• W4308366960 hasConceptScore W4308366960C154945302 @default.
• W4308366960 hasConceptScore W4308366960C184652730 @default.
• W4308366960 hasConceptScore W4308366960C2775842073 @default.
• W4308366960 hasConceptScore W4308366960C2777714996 @default.
• W4308366960 hasConceptScore W4308366960C2779610220 @default.
• W4308366960 hasConceptScore W4308366960C2779902710 @default.
• W4308366960 hasConceptScore W4308366960C2989005 @default.
• W4308366960 hasConceptScore W4308366960C41008148 @default.
• W4308366960 hasConceptScore W4308366960C55020928 @default.
• W4308366960 hasConceptScore W4308366960C71924100 @default.
• W4308366960 hasIssue "6" @default.
• W4308366960 hasLocation W43083669601 @default.
• W4308366960 hasLocation W43083669602 @default.
• W4308366960 hasOpenAccess W4308366960 @default.
• W4308366960 hasPrimaryLocation W43083669601 @default.
• W4308366960 hasRelatedWork W1549250237 @default.
• W4308366960 hasRelatedWork W1770372933 @default.
• W4308366960 hasRelatedWork W1980298740 @default.
• W4308366960 hasRelatedWork W1985106196 @default.
• W4308366960 hasRelatedWork W2008652046 @default.
• W4308366960 hasRelatedWork W2031978852 @default.
• W4308366960 hasRelatedWork W2157560517 @default.
• W4308366960 hasRelatedWork W2242953486 @default.
• W4308366960 hasRelatedWork W4229008978 @default.
• W4308366960 hasRelatedWork W4308366960 @default.
• W4308366960 hasVolume "35" @default.
• W4308366960 isParatext "false" @default.
• W4308366960 isRetracted "false" @default.
• W4308366960 workType "article" @default.