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- W4308366968 abstract "Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex. How DNA strands are chosen and selectively passed to yield appropriate topological outcomes – for example, decatenation vs. catenation – is poorly understood. Here, we show that at physiological enzyme concentrations, eukaryotic type IIA topoisomerases (topo IIs) readily coalesce into condensed bodies. DNA stimulates condensation and fluidizes these assemblies to impart liquid-like behavior. Condensation induces both budding yeast and human topo IIs to switch from DNA unlinking to active DNA catenation, and depends on an unstructured C-terminal region, the loss of which leads to high levels of knotting and reduced catenation. Our findings establish that local protein concentration and phase separation can regulate how topo II creates or dissolves DNA links, behaviors that can account for the varied roles of the enzyme in supporting transcription, replication, and chromosome compaction." @default.
- W4308366968 created "2022-11-11" @default.
- W4308366968 creator A5039868655 @default.
- W4308366968 creator A5043212526 @default.
- W4308366968 creator A5059012825 @default.
- W4308366968 creator A5060376151 @default.
- W4308366968 creator A5090496882 @default.
- W4308366968 date "2022-11-07" @default.
- W4308366968 modified "2023-10-16" @default.
- W4308366968 title "DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function" @default.
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