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- W4308367310 abstract "Abstract Considerable advances have been made in the research and development of oligonucleotide therapeutics (OTs) for treating central nervous system (CNS) diseases, such as psychiatric and neurodegenerative disorders, because of their promising mode of action. However, due to the tight barrier function and complex physiological structure of the CNS, the efficient delivery of OTs to target the brain has been a major challenge, and intensive efforts have been made to overcome this limitation. In this review, we summarize the representative methodologies and current knowledge of biodistribution, along with the pharmacokinetic/pharmacodynamic (PK/PD) relationship of OTs in the CNS, which are critical elements for the successful development of OTs for CNS diseases. First, quantitative bioanalysis methods and imaging‐based approaches for the evaluation of OT biodistribution are summarized. Next, information available on the biodistribution profile, distribution pathways, quantitative PK/PD modeling, and simulation of OTs following intrathecal or intracerebroventricular administration are reviewed. Finally, the latest knowledge on the drug delivery systems to the brain via intranasal or systemic administration as noninvasive routes for improved patient quality of life is reviewed. The aim of this review is to enrich research on the successful development of OTs by clarifying OT distribution profiles and pathways to the target brain regions or cells, and by identifying points that need further investigation for a mechanistic approach to generate efficient OTs." @default.
- W4308367310 created "2022-11-11" @default.
- W4308367310 creator A5004365170 @default.
- W4308367310 creator A5006409214 @default.
- W4308367310 creator A5074905943 @default.
- W4308367310 date "2022-11-16" @default.
- W4308367310 modified "2023-10-06" @default.
- W4308367310 title "Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives" @default.
- W4308367310 cites W1501727007 @default.
- W4308367310 cites W1530705137 @default.
- W4308367310 cites W1551220004 @default.
- W4308367310 cites W1857105967 @default.
- W4308367310 cites W1987338513 @default.
- W4308367310 cites W1989403240 @default.
- W4308367310 cites W1989730293 @default.
- W4308367310 cites W2000224259 @default.
- W4308367310 cites W2022093898 @default.
- W4308367310 cites W2024858641 @default.
- W4308367310 cites W2028623620 @default.
- W4308367310 cites W2031483194 @default.
- W4308367310 cites W2034181626 @default.
- W4308367310 cites W2044204671 @default.
- W4308367310 cites W2048594170 @default.
- W4308367310 cites W2052985891 @default.
- W4308367310 cites W2066234893 @default.
- W4308367310 cites W2070693578 @default.
- W4308367310 cites W2098741244 @default.
- W4308367310 cites W2100007022 @default.
- W4308367310 cites W2118656007 @default.
- W4308367310 cites W2127716652 @default.
- W4308367310 cites W2137437072 @default.
- W4308367310 cites W2163225965 @default.
- W4308367310 cites W2167183660 @default.
- W4308367310 cites W2204608617 @default.
- W4308367310 cites W2272525849 @default.
- W4308367310 cites W2283353698 @default.
- W4308367310 cites W2302021427 @default.
- W4308367310 cites W2316231782 @default.
- W4308367310 cites W2334882569 @default.
- W4308367310 cites W2337947575 @default.
- W4308367310 cites W2520424538 @default.
- W4308367310 cites W2535231956 @default.
- W4308367310 cites W2566127747 @default.
- W4308367310 cites W2571555848 @default.
- W4308367310 cites W2582323298 @default.
- W4308367310 cites W2582711285 @default.
- W4308367310 cites W2591728558 @default.
- W4308367310 cites W2602031224 @default.
- W4308367310 cites W2746311786 @default.
- W4308367310 cites W2749371381 @default.
- W4308367310 cites W2768540019 @default.
- W4308367310 cites W2769601563 @default.
- W4308367310 cites W2803361979 @default.
- W4308367310 cites W2804494151 @default.
- W4308367310 cites W2884457233 @default.
- W4308367310 cites W2895430781 @default.
- W4308367310 cites W2910531243 @default.
- W4308367310 cites W2913113106 @default.
- W4308367310 cites W2918616772 @default.
- W4308367310 cites W2930517794 @default.
- W4308367310 cites W2946564651 @default.
- W4308367310 cites W2972587866 @default.
- W4308367310 cites W2980602575 @default.
- W4308367310 cites W2980838798 @default.
- W4308367310 cites W2982134129 @default.
- W4308367310 cites W2982227296 @default.
- W4308367310 cites W2984780029 @default.
- W4308367310 cites W2996570951 @default.
- W4308367310 cites W3004199759 @default.
- W4308367310 cites W3009270825 @default.
- W4308367310 cites W3025374083 @default.
- W4308367310 cites W3039350432 @default.
- W4308367310 cites W3097605950 @default.
- W4308367310 cites W3108794039 @default.
- W4308367310 cites W3109433756 @default.
- W4308367310 cites W3110785280 @default.
- W4308367310 cites W3114158415 @default.
- W4308367310 cites W3114205754 @default.
- W4308367310 cites W3131848822 @default.
- W4308367310 cites W3138398505 @default.
- W4308367310 cites W3140573993 @default.
- W4308367310 cites W3159813053 @default.
- W4308367310 cites W3174704442 @default.
- W4308367310 cites W3187023153 @default.
- W4308367310 cites W3200470456 @default.
- W4308367310 cites W4200061939 @default.
- W4308367310 cites W4200306678 @default.
- W4308367310 cites W4200588978 @default.
- W4308367310 cites W4210584483 @default.
- W4308367310 cites W4220960596 @default.
- W4308367310 cites W4285278703 @default.
- W4308367310 cites W4296698991 @default.
- W4308367310 cites W4307178477 @default.
- W4308367310 doi "https://doi.org/10.1002/bdd.2338" @default.
- W4308367310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336817" @default.
- W4308367310 hasPublicationYear "2022" @default.
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