Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308367586> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4308367586 endingPage "101486" @default.
- W4308367586 startingPage "101486" @default.
- W4308367586 abstract "Cardiovascular disease (CVD) is a significant noncommunicable disease associated with high long-term mortality. In addition to more effective secondary therapies, the primary prevention of CVD has developed markedly in the past several years. This study aims to investigate the evidence and impact of reducing the threshold for primary CVD risk management to 10% over 10 years with statin therapy. To conduct research a systematic review utilizing 5 electronic database searches was completed for studies, analyzing the clinical effect of reducing the threshold of CVD risk to 10% over 10 years for primary prevention with statin therapy. The study included six (6) trials. Statin therapy was allocated to 31,018 participants. The mean age was 61 years and the mean follow-up was 4.6 years. The mean relative reduction in total cholesterol was 19% (from an average of), low-density lipoprotein cholesterol was 28.3% (from mmol/L to mmol/L) and triglycerides were 14.8% (from mmol/L to mmol/L). High-density lipoprotein cholesterol was observed to increase by a mean of 3.3% (from mmol/L to mmol/L). When examining all-cause mortality, statin therapy was associated with a 12% relative risk reduction compared with control, where overall rates were reduced from 1.4% to 1. % There is a 30% risk reduction in general major coronary events (from to %). There is a 19% risk reduction in general major cerebrovascular events with the statin group. While there is undoubtedly statistical evidence that supports the observation of the effectiveness of statin therapy for primary prevention, there is a risk that many hundreds of patients need to be treated to avoid a single adverse clinical outcome." @default.
- W4308367586 created "2022-11-11" @default.
- W4308367586 creator A5001522348 @default.
- W4308367586 creator A5008095396 @default.
- W4308367586 creator A5053006811 @default.
- W4308367586 creator A5055065011 @default.
- W4308367586 creator A5055905603 @default.
- W4308367586 creator A5064632922 @default.
- W4308367586 creator A5070308370 @default.
- W4308367586 date "2023-02-01" @default.
- W4308367586 modified "2023-09-25" @default.
- W4308367586 title "Reducing the Threshold of Primary Prevention of Cardiovascular Disease to 10% Over 10 Years: The Implications of Altered Intensity “Statin” Therapy Guidance" @default.
- W4308367586 cites W1978481613 @default.
- W4308367586 cites W2027659198 @default.
- W4308367586 cites W2095889878 @default.
- W4308367586 cites W2107579814 @default.
- W4308367586 cites W2115169717 @default.
- W4308367586 cites W2115752151 @default.
- W4308367586 cites W2164112965 @default.
- W4308367586 cites W2165472661 @default.
- W4308367586 cites W2200285648 @default.
- W4308367586 cites W2300022204 @default.
- W4308367586 cites W2405171365 @default.
- W4308367586 cites W2791783341 @default.
- W4308367586 cites W2907178034 @default.
- W4308367586 cites W2922829459 @default.
- W4308367586 cites W2943890763 @default.
- W4308367586 cites W2952095280 @default.
- W4308367586 cites W2957561054 @default.
- W4308367586 cites W2984766121 @default.
- W4308367586 cites W2989281995 @default.
- W4308367586 cites W3010535899 @default.
- W4308367586 cites W3032754295 @default.
- W4308367586 cites W3085323062 @default.
- W4308367586 cites W3125147070 @default.
- W4308367586 cites W3213486495 @default.
- W4308367586 cites W3216819171 @default.
- W4308367586 cites W4297752226 @default.
- W4308367586 doi "https://doi.org/10.1016/j.cpcardiol.2022.101486" @default.
- W4308367586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336115" @default.
- W4308367586 hasPublicationYear "2023" @default.
- W4308367586 type Work @default.
- W4308367586 citedByCount "0" @default.
- W4308367586 crossrefType "journal-article" @default.
- W4308367586 hasAuthorship W4308367586A5001522348 @default.
- W4308367586 hasAuthorship W4308367586A5008095396 @default.
- W4308367586 hasAuthorship W4308367586A5053006811 @default.
- W4308367586 hasAuthorship W4308367586A5055065011 @default.
- W4308367586 hasAuthorship W4308367586A5055905603 @default.
- W4308367586 hasAuthorship W4308367586A5064632922 @default.
- W4308367586 hasAuthorship W4308367586A5070308370 @default.
- W4308367586 hasConcept C126322002 @default.
- W4308367586 hasConcept C168563851 @default.
- W4308367586 hasConcept C2776839432 @default.
- W4308367586 hasConcept C2778163477 @default.
- W4308367586 hasConcept C2778213512 @default.
- W4308367586 hasConcept C2779134260 @default.
- W4308367586 hasConcept C2993857929 @default.
- W4308367586 hasConcept C44249647 @default.
- W4308367586 hasConcept C535046627 @default.
- W4308367586 hasConcept C71924100 @default.
- W4308367586 hasConcept C82789193 @default.
- W4308367586 hasConceptScore W4308367586C126322002 @default.
- W4308367586 hasConceptScore W4308367586C168563851 @default.
- W4308367586 hasConceptScore W4308367586C2776839432 @default.
- W4308367586 hasConceptScore W4308367586C2778163477 @default.
- W4308367586 hasConceptScore W4308367586C2778213512 @default.
- W4308367586 hasConceptScore W4308367586C2779134260 @default.
- W4308367586 hasConceptScore W4308367586C2993857929 @default.
- W4308367586 hasConceptScore W4308367586C44249647 @default.
- W4308367586 hasConceptScore W4308367586C535046627 @default.
- W4308367586 hasConceptScore W4308367586C71924100 @default.
- W4308367586 hasConceptScore W4308367586C82789193 @default.
- W4308367586 hasIssue "2" @default.
- W4308367586 hasLocation W43083675861 @default.
- W4308367586 hasLocation W43083675862 @default.
- W4308367586 hasOpenAccess W4308367586 @default.
- W4308367586 hasPrimaryLocation W43083675861 @default.
- W4308367586 hasRelatedWork W1993801935 @default.
- W4308367586 hasRelatedWork W2001593915 @default.
- W4308367586 hasRelatedWork W2029865314 @default.
- W4308367586 hasRelatedWork W2095512786 @default.
- W4308367586 hasRelatedWork W2110750045 @default.
- W4308367586 hasRelatedWork W2132187328 @default.
- W4308367586 hasRelatedWork W2161507199 @default.
- W4308367586 hasRelatedWork W4296312941 @default.
- W4308367586 hasRelatedWork W4308292563 @default.
- W4308367586 hasRelatedWork W2136187371 @default.
- W4308367586 hasVolume "48" @default.
- W4308367586 isParatext "false" @default.
- W4308367586 isRetracted "false" @default.
- W4308367586 workType "article" @default.