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- W4308367629 abstract "Abstract Psoriasis impacts various aspects of patients' health‐related quality of life and is associated with sleep problems. However, research discussing the associations between interleukin‐17 blockage therapies and sleep problems in patients with psoriasis is insufficient. We aimed to assess the effectiveness of brodalumab in alleviating sleep problems in real‐life patients with plaque psoriasis. This analysis was part of the single‐arm, open‐label, multicenter, prospective, cohort study, ProLOGUE (study period October 2017–March 2020), which involved Japanese patients with plaque psoriasis. Assessments included correlation of Medical Outcomes Study Sleep Scale–Revised (MOS Sleep‐R) scores (Sleep Problems Index‐II [SPI‐II] and MOS Sleep‐R subscale scores) with multiple patient‐reported outcome scores and the Psoriasis Area and Severity Index (PASI) at baseline. Additionally, change from baseline in MOS Sleep‐R scores was assessed at weeks 12 and 48 of brodalumab treatment. Seventy‐three patients were enrolled (male 82.2%, median age 54.0 years). At baseline, the SPI‐II score correlated with the Patient Health Questionnaire‐8 score (Spearman correlation coefficient [ ρ ] = −0.474) and weakly correlated with the Itch Numeric Rating Scale (NRS; ρ = −0.366), Skin Pain NRS ( ρ = −0.275), and all Treatment Satisfaction Questionnaire for Medication‐9 domain scores ( ρ = 0.270, ρ = 0.303, and ρ = 0.322 for effectiveness, convenience, and global satisfaction, respectively) but did not correlate with the PASI score. The SPI‐II score and MOS Sleep‐R subscale scores, except the Snoring score ( p = 0.0319), did not significantly change from baseline to week 12 of brodalumab treatment. In conclusion, treatment with brodalumab did not improve overall sleep problems in real‐life patients with plaque psoriasis, suggesting that sleep problems require attention in daily clinical practice (Japan Registry of Clinical Trials identifier, jRCTs031180037)." @default.
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- W4308367629 date "2022-11-07" @default.
- W4308367629 modified "2023-10-18" @default.
- W4308367629 title "Treatment with brodalumab is not associated with improved sleep problems in real‐life patients with plaque psoriasis: Results of the <scp>ProLOGUE</scp> study" @default.
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- W4308367629 doi "https://doi.org/10.1111/1346-8138.16620" @default.
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