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- W4308367806 endingPage "101791" @default.
- W4308367806 startingPage "101791" @default.
- W4308367806 abstract "Bone science has over the last decades unraveled many important pathways in bone and mineral metabolism and the interplay between genetic factors and the environment. Some of these discoveries have led to the development of pharmacological treatments of osteoporosis and rare bone diseases. Other scientific avenues have uncovered a role for the gut microbiome in regulating bone mass, which have led to investigations on the possible therapeutic role of probiotics in the prevention of osteoporosis. Huge advances have been made in identifying the genes that cause rare bone diseases, which in some cases have led to therapeutic interventions. Advances have also been made in understanding the genetic basis of the more common polygenic bone diseases, including osteoporosis and Paget's disease of bone (PDB). Polygenic profiles are used for establishing genetic risk scores aiming at early diagnosis and intervention, but also in Mendelian randomization (MR) studies to investigate both desired and undesired effects of targets for drug design." @default.
- W4308367806 created "2022-11-11" @default.
- W4308367806 creator A5031530236 @default.
- W4308367806 creator A5036667571 @default.
- W4308367806 creator A5067638427 @default.
- W4308367806 date "2022-09-01" @default.
- W4308367806 modified "2023-10-08" @default.
- W4308367806 title "Where is bone science taking us?" @default.
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