Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308367956> ?p ?o ?g. }
- W4308367956 endingPage "356" @default.
- W4308367956 startingPage "348" @default.
- W4308367956 abstract "Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases (MMPs), particularly membrane type-1 MMP (MT1-MMP), have failed. This is predominantly attributed to the specificity of MMP inhibitors and numerous functions of MMPs; therefore, targeting substrates with such broad specificity can lead to off-target effects. Thus, new drug development for cancer therapeutics should focus on the ability of MT1-MMP to break down substrates, such as functional cell membrane proteins, to regulate the functions of these proteins that promote tumor malignancy. In this review, we discuss the mechanism by which proteolysis of cell surface proteins by MT1-MMP promotes progression of malignant tumor cells. In addition, we discuss the two protein fragments generated by limited cleavage of erythropoietin-producing hepatoma receptor tyrosine kinase A2 (EphA2-NF, -CF), which represent a promising basis for developing new cancer therapies and diagnostic techniques." @default.
- W4308367956 created "2022-11-11" @default.
- W4308367956 creator A5032584020 @default.
- W4308367956 creator A5055488151 @default.
- W4308367956 creator A5071023264 @default.
- W4308367956 creator A5077446835 @default.
- W4308367956 creator A5085383498 @default.
- W4308367956 date "2022-11-24" @default.
- W4308367956 modified "2023-10-05" @default.
- W4308367956 title "Proteolytic cleavage of membrane proteins by <scp>membrane type‐1 MMP</scp> regulates cancer malignant progression" @default.
- W4308367956 cites W1088509254 @default.
- W4308367956 cites W1594899067 @default.
- W4308367956 cites W1597741096 @default.
- W4308367956 cites W1971275554 @default.
- W4308367956 cites W1976310806 @default.
- W4308367956 cites W1983921365 @default.
- W4308367956 cites W1986708715 @default.
- W4308367956 cites W1991693796 @default.
- W4308367956 cites W1995034367 @default.
- W4308367956 cites W1999355016 @default.
- W4308367956 cites W2006628284 @default.
- W4308367956 cites W2007724842 @default.
- W4308367956 cites W2009542532 @default.
- W4308367956 cites W2010254599 @default.
- W4308367956 cites W2011397767 @default.
- W4308367956 cites W2011980209 @default.
- W4308367956 cites W2015816598 @default.
- W4308367956 cites W2017454736 @default.
- W4308367956 cites W2025116429 @default.
- W4308367956 cites W2027256792 @default.
- W4308367956 cites W2034073392 @default.
- W4308367956 cites W2043521546 @default.
- W4308367956 cites W2045707438 @default.
- W4308367956 cites W2052084644 @default.
- W4308367956 cites W2053192881 @default.
- W4308367956 cites W2054331631 @default.
- W4308367956 cites W2061674473 @default.
- W4308367956 cites W2071946945 @default.
- W4308367956 cites W2074187493 @default.
- W4308367956 cites W2076782790 @default.
- W4308367956 cites W2079223115 @default.
- W4308367956 cites W2095333719 @default.
- W4308367956 cites W2099276286 @default.
- W4308367956 cites W2104886736 @default.
- W4308367956 cites W2109647778 @default.
- W4308367956 cites W2139429540 @default.
- W4308367956 cites W2145365512 @default.
- W4308367956 cites W2152055261 @default.
- W4308367956 cites W2167150493 @default.
- W4308367956 cites W2168369189 @default.
- W4308367956 cites W2171999622 @default.
- W4308367956 cites W2187985754 @default.
- W4308367956 cites W2605067960 @default.
- W4308367956 cites W2765322094 @default.
- W4308367956 cites W2800376069 @default.
- W4308367956 cites W2902221387 @default.
- W4308367956 cites W2905331035 @default.
- W4308367956 cites W2944434395 @default.
- W4308367956 cites W3011052309 @default.
- W4308367956 cites W3020124123 @default.
- W4308367956 cites W3035967781 @default.
- W4308367956 cites W3046215185 @default.
- W4308367956 cites W3046273104 @default.
- W4308367956 cites W3046750767 @default.
- W4308367956 cites W3080584368 @default.
- W4308367956 cites W3117437033 @default.
- W4308367956 cites W3134322915 @default.
- W4308367956 cites W3138042389 @default.
- W4308367956 cites W3141425948 @default.
- W4308367956 cites W3153806898 @default.
- W4308367956 cites W3182668743 @default.
- W4308367956 cites W3185259807 @default.
- W4308367956 cites W3190598238 @default.
- W4308367956 cites W4212810986 @default.
- W4308367956 cites W4283738700 @default.
- W4308367956 cites W4286487985 @default.
- W4308367956 cites W4308367956 @default.
- W4308367956 cites W47383406 @default.
- W4308367956 doi "https://doi.org/10.1111/cas.15638" @default.
- W4308367956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336966" @default.
- W4308367956 hasPublicationYear "2022" @default.
- W4308367956 type Work @default.
- W4308367956 citedByCount "4" @default.
- W4308367956 countsByYear W43083679562022 @default.
- W4308367956 countsByYear W43083679562023 @default.
- W4308367956 crossrefType "journal-article" @default.
- W4308367956 hasAuthorship W4308367956A5032584020 @default.
- W4308367956 hasAuthorship W4308367956A5055488151 @default.
- W4308367956 hasAuthorship W4308367956A5071023264 @default.
- W4308367956 hasAuthorship W4308367956A5077446835 @default.
- W4308367956 hasAuthorship W4308367956A5085383498 @default.
- W4308367956 hasBestOaLocation W43083679561 @default.
- W4308367956 hasConcept C101544691 @default.
- W4308367956 hasConcept C109523444 @default.
- W4308367956 hasConcept C121608353 @default.
- W4308367956 hasConcept C144647389 @default.
- W4308367956 hasConcept C181199279 @default.
- W4308367956 hasConcept C184235292 @default.