Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308369848> ?p ?o ?g. }
- W4308369848 endingPage "11" @default.
- W4308369848 startingPage "1" @default.
- W4308369848 abstract "Introduction: This study investigated the protective properties of Spondias mombin leaf extract (SML), in cerebral ischemia/reperfusion (I/R) mediated toxicity in the brain, liver, and kidney of male Wistar rats. Materials and methods: Animals were subjected to 30 min of bilateral common carotid artery occlusion followed by 24 h of reperfusion (BCCAO/R). The animals were divided into sham, I/R, and I/R treated with SML (25, 50 and 100 mg/kg) or quercetin (20 mg/kg) groups. Animals were sacrificed after 24 h of reperfusion and markers of organ toxicity (urea creatinine, glutamine synthetase (GS), glutaminase (GA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), acetylcholinesterase (AChE)) were measured in the brain regions (cortex, striatum, and hippocampus), liver, and kidney. Results and discussion: BCCAO/R significantly (p < 0.0001) inhibited the glutamate-glutamine cycle and mediated toxicity in the cerebral cortex, striatum, hippocampus, liver, and kidney of rats. Post-treatment with SML significantly (p < 0.0001) reversed glutamate-glutamine cycle inhibition and ameliorated cerebrohepatorenal toxicity in ischemic rats. Conclusion: Cerebral I/R significantly mediated cerebral, hepatic, and renal toxicity through the inhibition of glutamate-ammonia detoxification in rats, and SML protected against this post-ischemic glutamate-ammonia mediated multiorgan toxicity." @default.
- W4308369848 created "2022-11-11" @default.
- W4308369848 creator A5000531176 @default.
- W4308369848 creator A5021931656 @default.
- W4308369848 creator A5044398792 @default.
- W4308369848 creator A5045173723 @default.
- W4308369848 creator A5055723457 @default.
- W4308369848 creator A5060546981 @default.
- W4308369848 creator A5063853888 @default.
- W4308369848 creator A5065008314 @default.
- W4308369848 date "2022-11-23" @default.
- W4308369848 modified "2023-09-29" @default.
- W4308369848 title "Polyphenol-rich <i>Spondias mombin</i> leaf extract abates cerebral ischemia/reperfusion-induced disturbed glutamate-ammonia metabolism and multiorgan toxicity in rats" @default.
- W4308369848 cites W1009780732 @default.
- W4308369848 cites W1969894324 @default.
- W4308369848 cites W1971048984 @default.
- W4308369848 cites W1986545805 @default.
- W4308369848 cites W1998057817 @default.
- W4308369848 cites W2002384775 @default.
- W4308369848 cites W2004189243 @default.
- W4308369848 cites W2044444293 @default.
- W4308369848 cites W2051142023 @default.
- W4308369848 cites W2085907924 @default.
- W4308369848 cites W2104703549 @default.
- W4308369848 cites W2116390508 @default.
- W4308369848 cites W2133482394 @default.
- W4308369848 cites W2150460308 @default.
- W4308369848 cites W2159324150 @default.
- W4308369848 cites W2263023695 @default.
- W4308369848 cites W2319108958 @default.
- W4308369848 cites W2521316143 @default.
- W4308369848 cites W2550777855 @default.
- W4308369848 cites W2558366647 @default.
- W4308369848 cites W2604708117 @default.
- W4308369848 cites W2767430353 @default.
- W4308369848 cites W2788131326 @default.
- W4308369848 cites W2791597424 @default.
- W4308369848 cites W2797165607 @default.
- W4308369848 cites W2900674831 @default.
- W4308369848 cites W2910439767 @default.
- W4308369848 cites W2913338608 @default.
- W4308369848 cites W2913876336 @default.
- W4308369848 cites W2976291956 @default.
- W4308369848 cites W2983458279 @default.
- W4308369848 cites W2985914064 @default.
- W4308369848 cites W2996274646 @default.
- W4308369848 cites W3004645121 @default.
- W4308369848 cites W3012530761 @default.
- W4308369848 cites W3033017339 @default.
- W4308369848 cites W3037048917 @default.
- W4308369848 cites W3045965167 @default.
- W4308369848 cites W3081186543 @default.
- W4308369848 cites W3090647832 @default.
- W4308369848 cites W3113006441 @default.
- W4308369848 cites W3121366155 @default.
- W4308369848 cites W3159645519 @default.
- W4308369848 cites W3161507915 @default.
- W4308369848 cites W3178168279 @default.
- W4308369848 cites W4200381677 @default.
- W4308369848 doi "https://doi.org/10.1080/1354750x.2022.2145496" @default.
- W4308369848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36341500" @default.
- W4308369848 hasPublicationYear "2022" @default.
- W4308369848 type Work @default.
- W4308369848 citedByCount "0" @default.
- W4308369848 crossrefType "journal-article" @default.
- W4308369848 hasAuthorship W4308369848A5000531176 @default.
- W4308369848 hasAuthorship W4308369848A5021931656 @default.
- W4308369848 hasAuthorship W4308369848A5044398792 @default.
- W4308369848 hasAuthorship W4308369848A5045173723 @default.
- W4308369848 hasAuthorship W4308369848A5055723457 @default.
- W4308369848 hasAuthorship W4308369848A5060546981 @default.
- W4308369848 hasAuthorship W4308369848A5063853888 @default.
- W4308369848 hasAuthorship W4308369848A5065008314 @default.
- W4308369848 hasConcept C109549099 @default.
- W4308369848 hasConcept C126322002 @default.
- W4308369848 hasConcept C134018914 @default.
- W4308369848 hasConcept C170493617 @default.
- W4308369848 hasConcept C185592680 @default.
- W4308369848 hasConcept C2779289688 @default.
- W4308369848 hasConcept C2779349466 @default.
- W4308369848 hasConcept C2780091579 @default.
- W4308369848 hasConcept C29730261 @default.
- W4308369848 hasConcept C515207424 @default.
- W4308369848 hasConcept C55493867 @default.
- W4308369848 hasConcept C61174792 @default.
- W4308369848 hasConcept C71924100 @default.
- W4308369848 hasConcept C86803240 @default.
- W4308369848 hasConcept C98274493 @default.
- W4308369848 hasConceptScore W4308369848C109549099 @default.
- W4308369848 hasConceptScore W4308369848C126322002 @default.
- W4308369848 hasConceptScore W4308369848C134018914 @default.
- W4308369848 hasConceptScore W4308369848C170493617 @default.
- W4308369848 hasConceptScore W4308369848C185592680 @default.
- W4308369848 hasConceptScore W4308369848C2779289688 @default.
- W4308369848 hasConceptScore W4308369848C2779349466 @default.
- W4308369848 hasConceptScore W4308369848C2780091579 @default.
- W4308369848 hasConceptScore W4308369848C29730261 @default.
- W4308369848 hasConceptScore W4308369848C515207424 @default.