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- W4308370160 abstract "Antifouling and antibacterial are two critical challenges in the development of contact lenses (CLs). Herein, we presented nonfouling and antibacterial bifunctionalized CLs by encapsulating cationic heme-mimetic gallium porphyrin (Ga-CHP) into zwitterionic-elastomeric-networked (ZEN) hydrogel. Results proved that the ZEN hydrogel showed excellent abilities to resist non-specific protein adsorption, bacterial adhesion, and biofilm formation. Moreover, Ga-CHP could be sustainably released and kill >99.9% planktonic bacteria and >99.9% mature biofilms. In vivo, the symptoms of bacterial keratitis in mice were significantly alleviated after wearing the CLs for 7 days via iron-blocking and photodynamic synergistic antibacterial therapy with the help of natural sunlight. This study highlights the nonfouling and antibacterial superiority of the Ga-CHP-functional zwitterionic CLs and proposes a portable yet efficient non-antibiotic keratitis treatment strategy." @default.
- W4308370160 created "2022-11-11" @default.
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- W4308370160 date "2022-11-07" @default.
- W4308370160 modified "2023-10-09" @default.
- W4308370160 title "Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis" @default.
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- W4308370160 doi "https://doi.org/10.1021/acs.langmuir.2c02433" @default.
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